Dow Lab
@dow_lab
Cancer genetics & biology lab, building and applying new genetic technologies in search of better treatment options for cancer patients
Paper day! This one is a fantastic joint effort from @alynakatti and @AdrianVegaPerez. I tweeted about this >1 year ago when the #preprint dropped, but there was a lot added in review, so... here is iBE - a new inducible #baseediting mouse model! 1/15 go.nature.com/3KzCo2i
Ok, so unpopular opinion, I guess… I don’t think news entities should ever endorse political candidates. They can and SHOULD report objectively on all the terrifying stuff coming from DJT. I’d much rather honest reporting than ‘both-sidesing’ and editorial opinions. Inform us!
Haven't been on here since the first Tuesday in Nov, but... ...today I was promoted to Professor with tenure at @WeillCornell and wanted to post one last time to thank everyone that has helped our lab over the past 10 years! Science and guitar posts continue @dowlab.bsky.social
Alright, America… Let’s see if we can (finally) elect a more than qualified female candidate over an abundantly unqualified male. I’m looking at you, PA & WI. Vote!!
6 years of work + Over 2 years in review + 1 extremely talented graduate student @LeonaNease + Amazing collaborators = One extremely cool new mechanism that regulates metastasis through modification of the selenocysteine tRNA! nature.com/articles/s4301…
In no other field do you hire someone for their immense expertise in a very niche field and immediately ask them to change what they do… science is weird.
Can we retire the “How will you distinguish yourself from your postdoc advisor?” question that is typically asked of faculty candidates? I don’t think there is a meaningful answer that would inform a hiring decision one way or the other. Also, it’s silly.
Distinct clinical outcomes & biological features of specific KRAS mutants in human pancreatic cancer @Cancer_Cell doi.org/10.1016/j.ccel… 👉KRASG12R enriched in early stage w/ reduced nodal disease + distant recurrence 👉improved OS 🧐 Supports KRAS mutational testing in #PDAC…
@dow_lab we're looking forward to your presentation at #AMC25 in the Dominican Republic🇩🇴 next February! Please RT to let your followers know Talk Submission closes next week! ✅Register & Submit: bit.ly/3BbtGoY
10 years old today... the lab is double digits!! Happy birthday to us!
Online Now: Distinct clinical outcomes and biological features of specific KRAS mutants in human pancreatic cancer dlvr.it/TCXth0
Sure have enjoyed the last two weeks of hope-scrolling more than the past years of doom-scrolling! Can we keep this train on the tracks, please!! 🙏🏻
Dominican Republic in the “F-off” stage of winter, cool mouse models, some state-of-the-art gene editing… what more could you want?! Come hang on the beach!
📆Save the Date📆 Chairs @KevinHaigisLab & @SageJulien are back to bring us the second instalment of our Animal Models of Cancer conference. #AMC25 will take place from 26 Feb - 01 March 2025 in the Dominican Republic!✅Registration now open: bit.ly/3zK9wBP
📆Save the Date📆 Chairs @KevinHaigisLab & @SageJulien are back to bring us the second instalment of our Animal Models of Cancer conference. #AMC25 will take place from 26 Feb - 01 March 2025 in the Dominican Republic!✅Registration now open: bit.ly/3zK9wBP
8 months later, but now get to celebrate a safer (single digit) score on the A1! 🍾
TFW you’d love to celebrate an 11% R01 with everyone that worked hard to get it to this point, but you also have zero confidence congress will pass a reasonable budget to @theNCI to get it over the line…
This seems obvious now, but… For those using #mageck for heavily bottlenecked (positive selection) screens -> do your own read normalization, then turn off normalization when you run the package. Median normalization was wreaking havoc on our data
Can someone point me in the right direction here... trying to use #MAGeCK on some screen data - the table output says 'mean' but actually reports the median, and LFC looks to be calculated from that value. Is there a way to force the use of the mean for sgRNA level counts?
As per the PI code, I have completed the pointless check of eRA after 5pm on the final day of study section… now I’m clear for the weekend! #alwaysbecheckin’
Woohoo! Congrats Sal! Another reason to celebrate this week!
I’m thrilled and grateful to receive the career awards for medical scientists from @BWFUND. Thanks so much to my mentor and friends @dow_lab for their support. Looking forward to continuing these projects @MDAndersonNews