César de la Fuente
@delafuentelab
Presidential Associate Professor @Penn - using AI to reimagine antibiotic discovery and peptide design. Previously @MIT, @UBC
(1/5) Venoms are a vast, largely untapped library of bioactive molecules—and our new paper in @NatureComms @NaturePortfolio reveals just how powerful they can be. 🐍⚡️nature.com/articles/s4146…
I recently sat down with Drs. Quinn & Goldsmith to explore how intelligent systems are reshaping antibiotic discovery—freeing researchers from repetitive admin, and pointing toward a future of true “AI scientists.” We also confronted the harder questions: energy demand, server…

IA para predicción de eficacia y descubrimiento de antibióticos frente a patógenos emergentes 👇
For years I have dreamt of a tool that could neutralize pathogens the moment they emerge. Today we unveil ApexOracle—an AI that, from a pathogen’s genome and phenotypic knowledge alone, predicts which antibiotics will work and invents new molecules for threats it has never seen.…
Entrevista a nuestro académico @delafuentelab sobre cómo a partir del ADN de #bacterias se pueden diseñar #antibióticos @CESGA_ @AntonioGCaamano @ACIS_sergas @BidaFarma @Cofares @CofanoCoop @COFCoruna @RAMYCGA @axenciaGAIN @idis_research @SanidadeXunta @lavozdegalicia 👇👏
For years I have dreamt of a tool that could neutralize pathogens the moment they emerge. Today we unveil ApexOracle—an AI that, from a pathogen’s genome and phenotypic knowledge alone, predicts which antibiotics will work and invents new molecules for threats it has never seen.…
It was a great honor to receive the prestigious Fleming Prize. My lecture and a wide-ranging interview are now online; I hope they spark new ideas for the next generation of microbiologists. Grateful to @microbiosoc for sharing! youtube.com/watch?v=VRpHhS…
🐍 🕷️ #AI finds hundreds of potential #antibiotics in #snake and #spider #venom | @Penn Today @delafuentelab penntoday.upenn.edu/news/penn-de-l… #MedTwitter #AImedicine #AI #HealthAI #AIinHealthcare #MedTech
#Ciencia 🔬 César de la Fuente, el gallego que descubre antibióticos con IA: "Hacemos en horas lo que llevaba años" elprogreso.es/articulo/galic…
El coruñés César de la Fuente impulsa una investigación para sugerir antibióticos con el uso de IA #ACoruña #Coruña ift.tt/0dhwULX
For years I have dreamt of a tool that could neutralize pathogens the moment they emerge. Today we unveil ApexOracle—an AI that, from a pathogen’s genome and phenotypic knowledge alone, predicts which antibiotics will work and invents new molecules for threats it has never seen.…

Un algoritmo escanea millones de fragmentos de veneno animal y detecta potentes compuestos antibacterianos capaces de vencer infecciones resistentes. Así se abre una nueva vía hacia los antibióticos del futuro.
ft. @megclarks, Walter Mowel, @MFMich1, Leonel Joannas, @Notorious_MHC, Isabel Erickson, Jorge Henao-Mejia (@PennPathLabMed), Lexus Johnson, @andyjminn (@UPenn_I3H), @rakez_krish, @delafuentelab (@PennPsych) & @ksimeono (@PennVet) @ImmunityCP cell.com/immunity/abstr…
🐍 🕷️ #AI finds hundreds of potential #antibiotics in snake and spider #venom @delafuentelab #Venomology pennmedicine.org/news/ai-finds-… #MedTwitter #AImedicine #AI #HealthAI #AIinHealthcare #MedTech
New paper in @npjAMR @NaturePortfolio: a single course of meropenem leaves scars—mice stay in gut dysbiosis 30 days after clearing E. coli. A cautionary tale about the microbiome costs of antibiotics. 🦠 nature.com/articles/s4425…

Mi amigo @Pablofuente es un comunicador brillante. Tenemos la suerte de que siga de cerca nuestras investigaciones y acaba de publicar un magnífico resumen de nuestro último artículo en @NatureComms sobre el uso de venenos como antibióticos. ¡Gracias, Pablo!
1/18 Las bacterias resistentes a los antibióticos son como ladrones que han aprendido a forzar todas las cerraduras que usamos para proteger nuestra salud. Llevamos décadas sin inventar cerraduras nuevas y los ladrones se han muy eficiente. Esta es la crisis de la resistencia a…
A few weeks ago, I had the pleasure of visiting beautiful Siena to speak at the Palio Meeting, where we discussed the pressing issue of antimicrobial resistance. Grateful to @unisiena, @GSK, @gsk_it, @victornizet and all involved for the inspiring exchange.


PRL's latest forward-looking Essay: Using Machine Learning for Antibiotic Discovery
PRL Essay: César de la Fuente-Nunez and James J. Collins explore ways in which machine learning and artificial intelligence can substantially accelerate the discovery of antibiotics to keep pace with the ever-evolving landscape of drug-resistant pathogens go.aps.org/44P2sj8
1/18 Las bacterias resistentes a los antibióticos son como ladrones que han aprendido a forzar todas las cerraduras que usamos para proteger nuestra salud. Llevamos décadas sin inventar cerraduras nuevas y los ladrones se han muy eficiente. Esta es la crisis de la resistencia a…
Un equipo liderado por el gallego César de la Fuente (@delafuentelab) halla posibles antibióticos en venenos de animales con la ayuda de la IA ✍️ Reportaje de @Garcio72 farodevigo.es/sociedad/2025/…
Computational exploration of global venoms for antimicrobial discovery with Venomics artificial intelligence - nature.com/articles/s4146…
El equipo del gallego César de la Fuente extrae venenos mediante IA para nuevos antibióticos #Galicia ift.tt/d1gpjf4
.@Penn AI Discovers 53 Promising Antibiotic Peptides from Venom. The research team, led by Dr. César de la Fuente, fed the AI system a massive dataset of over 40 million venom-derived peptides. Within hours, APEX identified 386 candidates that exhibited the molecular hallmarks…