David MacHugh

Our @CommsBio #bovineTB #eQTL #TWAS #OneHealth paper on #WorldTBDay. Excellent #ComputationalGenomics work by @jf_grady & collaborators @roslininstitute, @ETH_en. Support @agriculture_ie, @Researchirel, @UCD_OneHealth, @UCD_Conway, @ucdagfood, @ucdvetmed nature.com/articles/s4200…

Structural variants are important! However, genotyping them accurately remains a challenge. We've sequenced 120 bulls with HiFi reads to investigate the contribution of structural variants to complex traits. biorxiv.org/content/10.110…

1/ Tucker Carlson: “Do you think overall the COVID vaccine killed more people than it saved?” RFK Jr: “The truth is, I don’t know.” This is outrageous. I do know. The answer is: unequivocally no. 🧵

Excited to share #AlphaGenome, a start of our AlphaGenome named journey to decipher the regulatory genome! The model matches or exceeds top-performing external models on 24 out of 26 variant evaluations, across a wide range of biological modalities.1/6

Thread: Multi-omics sounds cool—until you actually try it. Here's are the nuances. 1/ You’ve got RNA-seq. Methylation. Proteomics. Time to “integrate” the data. But how? And why? Let’s break it down.

Fantastic work @jf_grady - and thanks to our collaborators @LingzhaoF, @animal_eth, @icgormley, and #SteveGordon

1/ A study by Dr. Peter Hotez and colleagues estimates that over 200,000 Americans died needlessly during the COVID-19 pandemic—due to vaccine refusal fueled by disinformation. This thread breaks it down.

Thrilled to share that The Farm Animal Genotype–Tissue Expression (FarmGTEx) Project perspective paper is out ⁦@NatureGenet⁩. Thank all the authors for the efforts and supports. Looking forward to seeing amazing science coming from this initiative. nature.com/articles/s4158…

Great to see the Farm Animal Genotype–Tissue Expression (#FarmGTEx) Project perspective article published in @NatureGenet. A fantastic #livestock #FunctionalGenomics project led by @LingzhaoF at @AarhusUni_int. nature.com/articles/s4158…

Gratz to #KevinDaly @ucdagfood, @UCD_CHAS, and @UCD_Conway for this exciting @ScienceMagazine #paleogenomics and #PopulationGenomics study on the origins and dispersal of domestic sheep. This work was led by @brad_dan @tcdgenmicro. doi.org/10.1126/scienc…

I’ve seen my share of anti-science activists. But few are as dangerous as Vandana Shiva. She brands herself as a "food sovereignty" advocate. In reality? She’s an activist spreading misinformation about GMOs, pesticides, and modern agriculture. Here’s the real story 🧵: 1/

🧵1/2 The Guardian columnist who wrote yesterday's op-ed about Trump's executive order reached out to me Friday morning for some "expert commentary." TLDR: I provided her with plenty of scientific evidence/argument/detailed commentary in answer to her questions about Trump's…

Delighted to see our new paper out in Nature nature.com/articles/s4158…

The day has arrived! We are thrilled to kick off our research symposium “Irelands Future Food Systems”. Delighted to welcome UCD VP for @UCD_Research Kate Robson Brown to deliver our keynote address.

Gratz to @UCD_CHAS @ucdagfood #AnimalScience student @dermodkkelly for 1st Prize in the TCD @tcdgenmicro #GenomicsMedicine MSc 2023-24 class. This follows @GenomicsCRT PhD student @jf_grady who won in 2020-21 🧬😀🏆👍🧬

Huge congratulations to the new Dr @cosmint_ for an excellent PhD achievement. And many thanks to the examiners @LJRussell_Lab @david_machugh and chair David Gomez for putting him through his paces @GenomicsCRT