Angelo D'Alessandro

Now out @BloodJournal: Ferroptosis regulates hemolysis in stored RBCs. We identify STEAP3 (p53 target) as a key driver of stored RBC hemolysis by Fe-dependent lipid peroxidation @grkeele @jameszimring @bstockwell Gary Churchill @jacksonlab @GrierPage doi.org/10.1182/blood.…

First pediatric subject enrolled today at Le Bonheur Children's hospital in the first traumatic bleeding platform trial performed. Will LTOWB be superior to components? TXA to placebo? Will find out eventually! @theTHORnetwork @PittTTMRC @PittSurgery

I’m excited to share our latest study led by @GiuliaPasquesi out today in @CellPressNews , uncovering a new way transposons have been repurposed for human interferon signaling! Read on for a thread on cryptic splice variants, decoy receptors, and viruses (1/N) 👇🧵

Blood is a window on systems health. Great work from Higgins and colleagues @Nature shows that stability or setpoints in complete blood count parameters in 10s of thousands of patients over 20 years is associated with clinical risk and all cause mortality rdcu.be/d3dnf

Congratulations to @FCendali in the @dalessandrolab for receiving the 2024 Hematology Pathway Inclusion award for the top scoring abstract at this year’s American society of hematology conference.

We are loving Day 3 of #ASH24 with Gaslamp District of San Diego as backdrop (😍) Evolving #hematology therapies & patient care best practices♥️♥️♥️- our pioneering work means advancing our collective understanding ♥️♥️♥️ CU @ 66th ASH Annual Meeting: bit.ly/CUHematologyGo…

An unexpected paradox of aging and cancer. It has been great watching this story evolve over the past few years but glad to see it out. Congrats to everyone!

Just in time for #ASH24, our latest is online: nature.com/articles/s4159…

The central message behind our two recent papers in @NatMetabolism @MolSystBiol •• If you can’t identify it with XCMS-METLIN, highly likely it is ISF (in-source fragmentation) •• Both papers are open access nature.com/articles/s4225… embopress.org/doi/full/10.10…

Thanks for highlighting this really important effort to develop new prognostic criteria for new therapies. Have to do this for all new therapies, can’t assume that risk stratification systems developed for other therapies are relevant. More input and refinement to this is needed!

The human proteomic revolution proceeds with high-throughput assessment, AI analytics, correlation with health and disease, drug interactions, biomarkers cell.com/cell/fulltext/…

The Human Cell Atlas. Important work to map the 30-37 trillion cells in the human body. Hopefully these efforts will not completely ignore red blood cells, up to 83% of the cells in this count.

Our perspective in @ScienceMagazine on #Ferroptosis—#disease perils and #therapeutic promise science.org/doi/10.1126/sc… written for a general audience -- not too technical. Congrats to authors @ashleybrown015 and Tal Hirschhorn! @Columbia

Same!

Interesting study! Missense PLA2G6 SNPs are common in blood donors and are linked to RBC hemolysis from our study here - doi.org/10.1182/blood.… Another link between RBC hemolysis and kidney disease?

Highly Cited Researchers | Clarivate - Honored to be in such a shortlist and good company! ⁦@CUAnschutz⁩ ⁩ ⁦@CU_BMG⁩ ⁦@CUHemeOnc⁩ ⁦@DanPollyea⁩ clarivate.com/highly-cited-r…

My Twitter/X feed has turned into a mix of political propaganda/brainless videos, drowning out the interesting posts that originally attracted me to this platform. Like many others, I am giving it a good old try to BlueSky social. I will likely slowly discontinue my presence here