chuanbin

I'm excited to share our new publication in @CellGenomics! We examine the structure-function relationship between chromatin looping and RNA polymerase II-mediated gene expression during neural lineage commitment. Check it out! doi.org/10.1016/j.xgen…

I am excited to share our new work from @CreminsLab heterochromatin in fragile X syndrome (FXS), the most common monogenic cause of autism spectrum disorder. We previously described ectopic H3K9me3 domains in FXS, BREACHes, though the clinical significance is unexplored. 1/n

The geneticist who uses science to free parents wrongly convicted of killing their children @NaturePortfolio nature.com/articles/d4158…

Howdy! I'm thrilled to introduce FISHnet, a computational tool designed to identify chromatin domains within sequential Oligopaints DNA FISH data. Check it out on BioRxiv biorxiv.org/content/10.110… 🧵 ⬇️ ⬇️ ⬇️ (1/8).

🎉New paper🎉Introducing #StrandInteractions, the sequel to #LesionSegregation, published today @Nature Strand-resolved mutagenicity of DNA damage and repair nature.com/articles/s4158… Here’s what we discovered about (a)symmetry in replication, transcription & #mutagenicNER [1/13]

What are the functional roles of 3D genome organization? Our paper in @Nature led by @_prashantbhat demonstrates how dynamic 3D genome organization around nuclear speckles plays a crucial role in regulating mRNA splicing efficiency. rdcu.be/dHkez

Very inspired to have been involved in this very challenging but ultra exciting project since I joined @CreminsLab. The discovery of BREACHes let us understand the disease in a new way, but it’s just the beginning. The more is yet to come. Pls stay tuned. cell.com/cell/fulltext/…

Great article: Functional Enhancers Shape Extrachromosomal Oncogene Amplifications. QxMD.com/r/31761532 #ReadByQxMD

Great article: An operating system for the biology lab. QxMD.com/r/31554992 #ReadByQxMD

Methyl-HiC, DNA methylation and genome architecture in a single cell. nature.com/articles/s4159…

The internet is literally undefeated 😭😭😭 #Drake #KawhiLeonard

Pubmed: Transcribing Memories in Genome Architecture. dlvr.it/R83QPR

This system opens up the possibility of rapidly turning genes on and off in specific cells of the brain with potential disease applications. All this was made possible with support from an @NIHDirector's New Innovator Award! nature.com/articles/s4159… (2/2)

Excited to have our friend @Elmo hanging out with @Zionwilliamson, @RjBarrett6, and @camreddish today to celebrate @SesameStreet’s mission to help children everywhere grow smarter, stronger, and kinder!