The Boroviak Lab
@boroviak_lab
Shaping the future of human stem cell biology. Engineering embryo models. News from our Cambridge labs by Thorsten Boroviak, PhD.
We are thrilled that our marmoset embryo paper is out today in @Nature!!! nature.com/articles/s4158…
Many thanks to my wonderful hosts at the University of Sheffield @sheffielduni @a_tsakiridis for the kind invitation! Huge pleasure to share our latest work and to have open discussions with such a great research community!
Massive congratulations to @Amitesh__Panda on his PhD defence on human extraembryonic mesoderm! A brilliant example of how hard work and dedication lead to an important contribution to the field!
👩⚖️ A heartfelt thanks to my PhD defense panel: Dr. Frederic Lluis, Dr. @LeucciLRCB , Dr. Thorsten Boroviak @boroviak_lab , Dr. Maud Borensztein, and Dr. Atilgan Yilmaz @Atilgan__Yilmaz . I deeply appreciate your time, insightful questions, and valuable feedback.
Had an incredible time at @Yale! Huge thanks for the warm welcome and the chance to share our work at the seminar. Thrilled by the engaging discussions and brilliant minds! Special thanks to @BernaSozen_ Maurizio Chioccioli and @h4rrymcnamara!
Delighted to host Dylan Siriwardena for an exciting seminar in our department tomorrow! Dylan is a former PhD student from our lab and lead author of our marmoset trophoblast work. Welcome back in Cambridge, Dylan!
Brilliant review on extraembryonic mesoderm! It will be exciting to unravel its emergence, function and relation to extraembryonic endoderm. Congratulations to all authors! journals.biologists.com/dev/article-ab…
Great talk on mouse chimaeras, embryonic stem cells and FGF signalling in the early embryo! Looking forward to visiting Sheffield in May!
It was great to be back @Cambridge_Uni to give a talk @GurdonInstitute Developmental Biology Seminar Series, and to talk science with people from @PDN_Cambridge, @SCICambridge, @Loke_CTR, and @MRC_LMB! Spring has sprung @christs_college!
Our new BIOPRINTER is here! Amazing week with Prof. Kenny Dalgarno and crew from Newcastle University! The MiniREJI features three prinheads for bioprinting across scales! Massive thanks to our wonderful collaborators! @Drfati_ @isgibab
It is not too late! Explore BIOPRINTING with us in Cambridge! Place different cell types precisely where you want them. At near single-cell resolution. Live-demo, free lunch, networking opportunity and symposium on pioneering bioprinting applications.
BIOPRINTING in Cambridge! Join our NC3Rs Workshop on bioprinting 3D in vitro models. Discover our new prototype and connect with the Cambridge bio-engineering community. 28th February, at the Cambridge Stem Cell Institute! This event inaugurates the new MiniREJI!
SOX17 is a master regulator of endoderm differentiation, but what if you tweak just ONE amino acid? Turns out that most mutations at pos. 57 turn SOX17 into a pluripotency inducer! Congrats to @Jessie_HSY (now @boroviak_lab ) and @haoqing_hu from @jauchr 's team at @hkumed…
Amazing opportunity to learn more about embryogenesis, the placenta and fetal growth! Spread the word and we are looking forward to seeing you in Cambridge this July!
#announcement please share 📢 Annual Meeting 2025 'The Placenta at Term' registration live bit.ly/annualmeeting25 Applications open for Placental Biology Course, in-person, in Cambridge this September bit.ly/placentalbiolo… 25 places, application deadline 21 March!
Curious embryo fact 25/25 The Virginia opossum has the shortest gestation period of all mammals. After 12 days, opossum babies are born extremely underdeveloped, resembling tiny jellybeans. They immediately crawl into their mother’s pouch for continued growth and protection!…
Curious embryo fact 24/25 Human sperm are amongst the smallest cells of the body. They are remarkable swimmers, capable of traveling up to 15cm per hour and surviving for up to 5 days inside the female reproductive tract. Their swimming abilities and prolonged lifespan…
Curious embryo fact 23/25 The African elephant has the longest gestation period of any land mammal. It lasts an incredible 22 months. This lengthy period allows the calf to reach a birth weight of 120kg! #devbio #embryo #reproduction
Curious embryo fact 22/25 Placentation strategies are highly variable amongst species. Ruminants, such as cattle, sheep, and deer, have evolved less invasive placentas, allowing for a quicker recovery post-birth. This is crucial for their survival in environments where…
Curious embryo fact 21/25 The human fertilised egg (zygote) is 0.1mm, the size of a speck of dust. At 4 weeks, the human embryo is about 1mm, similar to a poppy seed! By the end of 8 weeks, the embryo is 2.5cm with arms and legs - imagine a grape with tiny limbs! #devbio…
Feeder-free culture of naive human pluripotent stem cells retaining embryonic, extraembryonic and blastoid generation potential biorxiv.org/content/10.110…
Curious embryo fact 20/25 In marsupials, such as kangaroo, koala and wombat, the embryo does not contain an inner cell mass at the blastocyst stage. Instead, they form an empty sphere! A selection of outer cells will give rise to the marsupial embryo. #devbio #embryo…
Embryo facts are BACK! Want to learn about how life begins? Twice a week, we will share fascinating facts about how life forms. Stay tuned and repost! #Embryology #StemCells #DevBio #EmbryoFacts #SciTwitter
Human embryos have an anterior visceral endoderm (AVE). The AVE is a key signalling center for body axis formation. Top spatial transcriptome study on the earliest postimplantation human embryo yet - congratulations to all authors! Key points are - Earliest mesoderm subtypes,…