danny hsu

Good start of year 2025 with the last publication from my postdoc work where we dissected the role of individual domains in amyloidogenic behavior and soluble toxicity of a light chain associated with AL amyloidosis recently accepted in @JMolBiol 10.1016/j.jmb.2025.168958

Combining SAXS, MD simulations and HDX-MS, we identified a new conformational (H) state in AL LCs. This state could be a better target of LC stabilizers. In @eLife: A conformational fingerprint for amyloidogenic light chains doi.org/10.7554/eLife.… @stericagno @asibc512

Very pleased to know that our recent work on hCoV-229E S:hAPN recognition has been highlighted by Nature Communications alongside the work of the newly minted Nobel Prize laureate David Baker lnkd.in/gUwr4bqZ

We are thrilled to welcome @MakotoShirakaw2 joining @IPMBSinica as a new PI in this fall. Look forward to exciting research expanding our plant development groups

@IPMBSinica summer undergraduate internship program is now open for applications! 🔗 Apply here: internship.ipmb.sinica.edu.tw/program 📆 Deadline: April 30, 2025

We used cryoEM and mass spectrometry glycoproteomics plus GlycoSHIELD to determine the molecular structure of human coronavirus 229E spike protein in complex with its human receptor, hAPN in a 6:2 binding stoichiometry. doi.org/10.1038/s41467…

The 2024 Franco-Taiwanese Scientific Grand Prize was presented to Danny Shang-te Hsu, deputy director of the Institute of Biological Chemistry at Taipei City-based Academia Sinica, and Cyril Hanus, research fellow at the Institute of Psychiatry and Neuroscience of Paris in Taipei

Happy to share our work on conformational states of amyloidogenic light chains published as preprint in eLife doi.org/10.7554/eLife.… Thanks to reviewers for doing great job. We will revise soon to make paper more impactful 💪 carlo camilloni @stericagno @asibc512

Check out our latest invited review published in @FrontiersIn Biophysics explaining why dynamics in deubiquitinase (DUBs) enzymes matter more than their static structures for function and pathological consequences. Check doi.org/10.3389/frbis.… with @asibc512

AI systems capable of #protein structure prediction and protein drug design won #NobelPrize2024 Prize in Chemistry. IBC professors Dr. Kuen-Phon Wu and Dr. Shang-Te Danny Hsu commented in an online interview. See the following link for more details: smctw.tw/17785/

🔬Publication - by @asibc512 @jbiolchem This study reveals the structure and interaction of #ZFAND1 and #p97, providing a better understanding of the clearance of #arsenite-induced #stress granule. doi.org/10.1016/j.jbc.… #biochemistry #zincfinger

CryoEM workshop at @AcadSinica by @KPWu11 from @IBCSinica 100 participants for a whole day of ultra-cool stuff.

🔬Publication - by @asibc512 @khooAS @CellCellPress By using glycoSHIELD, a #reductionist method that reveals the structure of ensembles of #glycans, the impact of glycans on the conformation and activity of complex #glycoproteins are demonstrated. doi.org/10.1016/j.cell…

Live music affects the brain differently than recorded music, according to a study. Live piano performance elicited stronger activity in the amygdala and in a broader neural network for emotion processing than recordings of the same pieces. In PNAS: ow.ly/gtut50QJVpg

Chronicle of GlycoSHIELD in German :) Zelloberfläche: Wechselwirkungen lassen sich einfacher simulieren deutschlandfunk.de/zelloberflaech… @cyril_hanus @BioPhysMatt @IBCSinica @AcadSinica

Sugar coating of membrane proteins has been the Emperor’s New Clothes for structural biologists due to the intrinsic dynamics. Kudos to team @BioPhysMatt @cyril_hanus we now have GlycoSHIELD sciencedirect.com/science/articl… in Cell to aid visualization of glycans

🔥🔥🔥Thanks @cyril_hanus this was a wild ride! congrats to all co-authors, amazing support from @MCB_UJ, @MPIbp, @HummerLab #DioscuriCentres. Definitely #glycotime!