@markandermann.bsky.social
@andermann_mark
Neuroscientist. Canadian.
A drop of milkshake takes a wild ride after it is swallowed. Rachel and Kiersten came up with cool strategies for visualizing food passing through the mouse GI tract and mapping the activity of the same 100s of brainstem neurons across weeks during feeding and other behaviors.
I’m so excited to share our preprint on how brainstem neurons sense and integrate multiple body signals during food consumption. We imaged 1000s of neurons across the lateral parabrachial nucleus (LPBN) in behaving mice. biorxiv.org/content/10.110…
Stand Up for Science rally, March 7, 12-4 pm, Boston Common. Better than moping. eventbrite.com/e/stand-up-for…
NEW: Mark Andermann (@andermann_mark) of @harvardmed and @BIDMChealth brings experimental data and computational modeling together to understand cortical reactivations. Watch the video: youtu.be/1N6i7Zi9kXs #NeuroAI2025 #neuroscience #AI #NeuroAI
We previously showed that specific hypothalamic neurons get more and more activated by each bite of food until they put a brake on homeostatic feeding. Here, we find that this brake is already on at the start of a meal in obese mice on a high-fat diet. Nice work, Marta & team!
🚨Paper alert! 📣 We found abnormal feeding-related neural responses in satiety-promoting, MC4R-expressing neurons in the mouse paraventricular hypothalamus (PVHM-C4R) following diet-induced obesity. biorxiv.org/content/10.110… #obesity #feedingbehaviour #obesityresearch
I’m so excited to share our preprint on how brainstem neurons sense and integrate multiple body signals during food consumption. We imaged 1000s of neurons across the lateral parabrachial nucleus (LPBN) in behaving mice. biorxiv.org/content/10.110…
[1/4] Registration for our two-day virtual & in-person symposium in June is now open! See below for the full list of cutting-edge experts in #neuroscience and #AI speakers:
We lack tools to track >1-2 changing signals in brain fluids. Peter Kalugin and an amazing team begin to address this challenge with simultaneous, real-time tracking of many (10+) neuromodulatory signals using Multiplexed Optical Recording of Sensors on a micro-Endoscope (MORSE).
I’m thrilled to share our preprint presenting MORSE: a new way to simultaneously and quantitatively track patterns of neuromodulators/neuropeptides in vitro & in vivo using spatially multiplexed 3D imaging of 10+ green optical sensors on a microendoscope. biorxiv.org/content/10.110…
I am thrilled and grateful to share that I’ll be starting my lab at @ISTAustria in June 2025! We will study how the hypothalamus maintains homeostasis in response to challenges. Check out our website: dmhlab.org, and if interested please get in touch!
In other words, perhaps we should consider slowing down and savoring each moment.
We found that in vivo peptide release and signaling gradually enhances the response of satiety-promoting hypothalamic neurons to each bite of food during a meal. These consequences of each bite take minutes to manifest, and could help explain why slow eating enhances satiety.
I am thrilled to share the published version of our study on how neuropeptide signals regulate feeding in the hypothalamus! We imaged endogenous peptide signals in subcellular compartments during behavior. Below is an updated summary: rdcu.be/dZlI3
We found that in vivo peptide release and signaling gradually enhances the response of satiety-promoting hypothalamic neurons to each bite of food during a meal. These consequences of each bite take minutes to manifest, and could help explain why slow eating enhances satiety.
I am thrilled to share the published version of our study on how neuropeptide signals regulate feeding in the hypothalamus! We imaged endogenous peptide signals in subcellular compartments during behavior. Below is an updated summary: rdcu.be/dZlI3
Pretty exciting result: disrupting cue reactivations in mouse visual cortex in the hours *after* operant training completely blocks learning.
I am thrilled to share the published version of our study on how neuropeptide signals regulate feeding in the hypothalamus! We imaged endogenous peptide signals in subcellular compartments during behavior. Below is an updated summary: rdcu.be/dZlI3
Our perspective on the frontiers of neuroscience beyond the nervous system. Thank you, @CellCellPress, for the opportunity to collaborate with our partners @NadineGogolla and @SLiberles. Thanks Chi Jingyi and Popescu, Miranda. My special thanks to Megan Sammons.
How our brain and body talk to each other, with control of inflammation and our immune response cell.com/cell/fulltext/… @CellCellPress @rolls_asya @NadineGogolla @PopescuMiranda @SLiberles and colleagues, open-access
Out in @CellCellPress now with added data and analysis! @Huixin_BJ and colleagues report that the choroid plexus has specialized epithelial-immune synergy that modulates epithelial barrier plasticity during brain inflammation. authors.elsevier.com/sd/article/S00…
What questions should we be asking as neuroscientists, and how should we go about answering them in satisfying and innovative ways? I think that seeking training in Stephen Zhang's nascent lab @NYU_CNS is a great way to find answers to these questions in an amazing environment.
My lab at @NYU_CNS is recruiting trainees at all levels starting in Jan 2025! Our goal is to understand how behavioral variables such as calorie intake and time estimates are computed using molecules inside individual neurons. stephenzhanglab.org
Stress can trigger willful seeking of a starvation-like state in certain female mice predisposed to higher anxiety. Now published and downloadable here: authors.elsevier.com/a/1iyP-3BtfH9A… Congrats to lead-author @haganK, @Oren_Amsalem, @andrewlutas, and the whole team. Feedback welcome!
What triggers anorexia nervosa? We find that chronic stress can trigger willful seeking of a starvation-like state in mice. As in humans, this was enriched in female mice, particularly those predisposed to stress. biorxiv.org/content/10.110… 1/7