Yulab
@YulabJin
breaking one CH bond per day...keeping headaches away...
This enantioselective nucleophilic CH fluorination was finally realized in collaboration with BMS colleagues, what a fantastic collaboration!
We had two ideas to close catalytic cycle for CH activation in 2001: one is CH oxidation with peroxides via Pd(IV) (Koten, Canty); one is CH coupling with RB via Pd(0) (Suzuki). Overwhelmed to be connected to the legend this way…
Prof. Jin-Quan Yu (@YulabJin) will receive the 5th Akira Suzuki Award for his research on C–H bond activation, which makes it easier to build complex molecules. His work accelerates advances in pharmaceuticals, molecular tools and materials science. More: ow.ly/z0BL50WhOQf
Today, NSF announced an add’l 500 NSF Graduate Research Fellowship Program awardees for the 2025-2026 cohort, bringing the total to approx 1,500. #NSFGRFP supports grad students as they pursue their dreams, build STEM skills, & become the next generation of innovators & leaders.
Weak coordination is very powerful with the help from bifunctional ligands; making secondary alkyl-fluoride building blocks from diverse simple substrates is highly valuable in drug discovery: pubs.acs.org/articlesonrequ…
Enantioselective CH activation is still on gas pedal. for broad applications, we must develop new catalysts for reacting CH with nucleophiles: pubs.acs.org/doi/10.1021/ja…. What is your wish list? NaF? NaCl? H2O? NH3?
A high bar for CH reactions to be relevant for sustainable polymer synthesis. Incredible efforts from a Germany Tech Institute to improve and pressure test one of our C-H reaction towards industrialization, even solvent needs to be omitted: just soap in and gold out!
EnantioCH by our MPAA ligand fills a gap in chiral technology; creating new chemical space for both drug discovery and chiral ligands: pubs.acs.org/articlesonrequ…
New chemical space in drug discovery means positioning H-A, H-D, pi-interactions, etc within various distal and geometric relationships at angstrom precision. CH activation at different sites have now arrived in large quantities to do just that: cnbc.com/2025/01/30/fda…
First in class pain killer FDA approved: endpts.com/vertexs-non-op…. Great fun memories working with Vertex on CH editing of this THF, THP scaffolds. 80 M patients annually could benefit
A magic spoon of table salts for aliphatic acids in 2007 guided us along the path of CH activation based on weak coordination, leading to discoveries of 10 distinct classes of bifunctional ligands so far, but ketones are too slippery until now: Nature: 10.1038/s41586-024-08281-4
EJ: the man, the myth, the legend
Position- and Enantioselective Catalytic Epoxidation of Polyolefins by a Chiral Mn Complex, Including a One-Step Conversion of Squalene to the (S)-2,3-Epoxide, a Precursor of Natural Steroids and Terpenoids | JACS @HarvardCCB @Harvard @TotalSyntheses pubs.acs.org/doi/10.1021/ja…
Design of chiral bifunctional ligands Continues to expand the scope of enantio-CH activation reactions, even when FG and CH are out of plane. Next will be ketone to conquer…
Synthesis of Chiral Saturated Heterocycles Bearing Quaternary Centers via Enantioselective β-C(sp3)–H Activation of Lactams | Journal of the American Chemical Society @YulabJin @scrippsresearch @TotalSyntheses Enantioselective Pd catalyzed CH Arylation pubs.acs.org/doi/10.1021/ja…
Today marks a monumental milestone: 100 years of pioneering science at Scripps Research. 🎉 On December 11, 1924, philanthropist and journalist Ellen Browning Scripps laid the foundation for what would become a globally renowned institute. Learn more at 100.scripps.edu.
Wonderful host. Great talks from @engle lab, @Giri_Research and collaborators from BMS and Vividion. Chemistry really matters in drug discovery.
Hearty congratulations to @YulabJin for receiving the 2024 NJACS OTG Award for Creativity in Molecular Design & Synthesis, and huge thanks to the organizers and sponsors! @scrippsresearch @AcsJersey @ACSorganic #BMSChemistry #MerckChemistry 🎉 👏🏻
Amazing collaboration with Stoltz group @Caltech and Davies group @EmoryUniversity! Our part was to achieve tetra-CH hydroxylation via weak coordination at very late stage of complex total synthesis: science.org/doi/10.1126/sc…
CH Lactonization is a way for oxidation. we have done beta lactone, now gamma lactones. Controlling site-selectivity between CH3 and CH2 by catalyst is really challenging: pubs.acs.org/articlesonrequ…
