Andrew Vickers
@VickersBiostats
Biostatistician at Memorial Sloan Kettering Cancer Center. Special interest in prostate cancer, risk prediction, patient-reported outcomes, decision-making.
A comment on some invalid criticisms of the radical prostatectomy lymph node dissection trial sciencedirect.com/science/articl…
The Gleason score - the fundamental determinant of how we chose on treatments in localized prostate cancers - basically doesn't make any sense.
.@VickersBiostats, @WeillCornell, discusses the need for reforming the Gleason score, the cornerstone of decision-making in #ProstateCancer management. #Gleason #biopsy #Urology
.@VickersBiostats, @WeillCornell, discusses the need for reforming the Gleason score, the cornerstone of decision-making in #ProstateCancer management. #Gleason #biopsy #Urology
I keep hearing "AI models have to be explainable otherwise doctors and patients won't trust them". But if I Google "does explainability improve trust in AI?", I get an AI summary (short answer "yes") created by an AI process that probably <1% of the population understands.
Results of observational study almost perfectly match those of our RCT. Hazard ratios of 1.07 / 0.72 for BCR / mets; RCT reported 1.05 / 0.82. Conclusions: do extended PLND during radical prostatectomy; effects of PLND occur after BCR.
Confirmation of the results of our RCT showing that PLND reduces metastasis without affecting BCR. @UrologyMSK @Uroweb @EUplatinum @JUrology @VickersBiostats #prostatecancer
With my kids after Robin (bottom left) wins Gold at U24 Ultimate Frisbee World Championshps
Note how "IV magnesium associated with less AKI" in the paper becomes "IV magnesium reduced AKI risk" in the tweet.
Simple, but yet effective. Giving IV magnesium before cisplatin reduced AKI risk! A small step that protects kidneys while treating cancer. #Oncology #Nephrotoxicity #cisplatin #OncoNephrology @JAMAOnc @OncoAlert @OncBrothers
"Patients with grade group (GG) 1 on biopsy can have higher grade disease on surgery. So GG1 = cancer". But also true of benign: "Patients with benign on biopsy can have higher grade disease on surgery"
Sounds great. It’s good that you’ve never over promised before and the American public can trust you.
We’re combining efficiency and gold-standard science to ensure the U.S. remains the global leader in advancing medical cures. Listen to the latest FDA Direct conversation where we discuss the Commissioner National Priority Voucher program. youtu.be/svqUa0jRXbY
Gleason pattern 4 quantification outperforms other prognostic markers.
Biopsy Gleason 4 Length on Prostate Biopsy can be a good predictor for early oncological outcomes after surgery. Our research @URMCUrology journals.lww.com/juop/fulltext/…
🚨New in @EUPlatinum! 📌 PSMA PET for Prostate Cancer Diagnosis & Staging by @elio_mazzone et al 🧠 This comprehensive meta-analysis confirms the high diagnostic value of PSMA PET—especially when combined with MRI—but reminds us it’s not enough to skip biopsy or lymph node…
🧠 Words matter in science. 📢 In their @EUPlatinum article, Vickers & Inman call for stricter labeling of clinical trials: ❌ Don't call single-arm studies “phase 3” ❌ Don’t mix “registrational” with “phase 2” ✅ Let’s keep trial terminology precise—for better science &…
Systematic review: "PSMA PET cannot be used alone to determine the need for lymph node dissection (LND)." sciencedirect.com/science/articl… PSMA and anti-LND advocates: "let's use PSMA to stop doing LND"
youtube.com/watch?v=cStGui… One year later another must see episode of @gu_onc, @Tilki_De gives an excellent insight on the most controversial change on PCa guidelines: no LND! Just got one doubt PET-PSMA staging for intermediate-unfav or just ISUP 3? @declangmurphy @RenuEapen
Trump Administration Live Updates: Judge Rules N.I.H. Grant Cuts Illegal, Orders Funds Restored nytimes.com/live/2025/06/1… via @NYTimes
Quality of Informed Consent via #Telemedicine Compared With In-Person for Clinical #Cancer Research. ascopubs.org/doi/10.1200/OP… @ASCO @JCO_ASCO @JCOOP_ASCO #CancerResearch #Telehealth @MSKCancerCenter @VickersBiostats
Well, even though we're 3rd place after vaccines and dino diets 😆, this was a fun conversation to have about #prostatecancer #screening #psatesting with @scifri, together w/ @VickersBiostats
Happy Science Friday…the 13th! Here’s what we’re covering today on the show. Pick the story you’re most excited about and tune in on your local public radio station, 2-4 p.m. ET. 🎧🚀🦕
Psychometricians develop questionnaires, then require permission to use / modify. Is there any other scientific methodology, whether lab (eg PCR), statistical (eg ttest), design (eg factorial), psychologic (eg cognitive debrief), where originators demand such permission?
Let’s just all agree to accurately quote him.
This tweet, like many others you've posted in recent days about Vinay, and about the new FDA that could be worse than the old one etc., are, in my view, in very poor taste, for several reasons. 1- "VP", as you call him, has shaped many of your ideas over the years 2- Vinay has…
Forgive me for not trusting your "common sense" @DrMakaryFDA Let me know when you and @VPrasadMDMPH have any RCTs to show us.
In the most recent @JAMA_current, I outline our priorities for a new FDA, incorporating the two guiding principles of our philosophy: gold-standard science and common sense. jamanetwork.com/journals/jama/…