The Clevers Lab

Do you want to learn how to make mouse thymus organoids? Our lab recently published a STAR Protocol on generating thymic epithelial organoids from adult mouse thymus tissue. Read it here: doi.org/10.1016/j.xpro… #Thymus #Organoids #STARProtocol #TEC

Our PhD student Sam presented our work on thymus organoids at this year’s Global Thymus Network meeting, ThymUS 2025. #ThymUS2025 #Organoids #Thymus

Check out new @TheScientistLLC article highlighting our postdoc @AmandaARolf ’s work on a novel pancreatic organoid model that includes all three key cell types, offering new insights into pancreatic development: the-scientist.com/a-novel-three-…

📢New human fetal pancreatic organoid model generates all three key cell types of the pancreas. New paper in @CellCellPress by @AmandaARolf , @HansClevers and collaborators. See the article here: sciencedirect.com/science/articl…

Recent work from our lab explored the role of multiple nuclear receptors in the human small #intestine. Using #organoids and small molecules, we activated and then studied one nuclear receptor at the time through transcriptome characterization. doi.org/10.1073/pnas.2…

Watch back the 2024 EMBL Kafatos Lecture where ⁦@HansClevers⁩ presented about the application of organoids in disease modeling at the ⁦@_knaw⁩ Amsterdam. #embl #knaw #organoids youtube.com/watch?v=eePX-M…

Exciting study! Organoid models reveal a novel role for human tuft cells in gut regeneration upon damage. Video: Tuft cell division is triggered by IL-4, visualized in human gut AVIL-Clover reporter organoids (Credit: Daniel Krueger) nature.com/articles/s4158…

Our postdoc @TheodoreGrenier visiting the @ENSLyon to talk about his research on #IBD and #organoids.

One bacterial protein as a complement to #Matrigel/#BME: The #integrin -binding domain of the Yersinia bacterial protein Invasin, coated as a single protein, maintains a defined long-term culture of various epithelial cells as “2D #organoid sheets”. biorxiv.org/content/10.110…

The Clevers lab is represented at the #ERSCongress in Vienna, with @nella_dost presenting her primary human alveolar lung organoid model @EuroRespSoc #organoid

Do you want to genetically engineer your organoids rapidly and accurately? Check out our recently published STAR Protocol about implementing Base and Prime Editors in organoids! A protocol developed by @CelottiMartina and @geurts_maarten star-protocols.cell.com/protocols/3589

Another great collaboration with @Axel_R_Huber, @Cayetanopm, @JoskeUbels, @HansClevers, @BoxtelLab and many others. Random forest trained with #organoid #colibactin mutations => identification of pks-linked mutations in every 8th #colorectal tumor genome! authors.elsevier.com/sd/article/S15….

British science giants, laid to rest in the north aisle of the nave of Westminster Abbey (also includes my feet...)

How do stem cells form enteroendocrine cells of the gut? @TheCleversLab, @prinsesmaximac and @MaastrichtU used human gut organoids to answer that question and identified ZNF800 as a key regulator. The results were published in Science today! Read more: hubrecht.eu/traffic-light-…

The clevers lab is at the EMBL organoid symposium. Come see our posters today and tomorrow. Todays posters are: 75, 147, 169 Tomorrows poster are: 52, 64, 162, 252, 254

📣 New VHIO – @CaixaResearch Scientific Seminars @FundlaCaixa❗️ 👨‍🔬 @Cayetanopm, @TheCleversLab @_Hubrecht 🔹 Using organoids to dissect the role of mutagenic bacteria in colorectal cancer 🗓 Friday, 28th April, 12:00pm 👨‍🔬 Host: @PaoloNuciforo  ➕bit.ly/CayetanoSemina…

Rare cell type in the spotlight: Transcriptomic profile comparison reveals ionocyte core signature across multiple mammalian organs. Read it here in @SciReports by Carla Pou Casellas and @Cayetanopm: doi.org/10.1038/s41598… #ionocytes #transcriptomics

Macrophages are an abundant immune infiltrate in lung cancer. We reviewed the use of 3D models for studying macrophage-epithelium interactions in this context. Now online @eLife by @katarinabal, @HansClevers and @nella_dost #organoids #NSCLC #macrophage doi.org/10.7554/eLife.…