TambarLab
@TambarLab
Organic chemistry lab interested in reaction development, total synthesis, chemical biology, and drug discovery
Grad student Tiffany Brisco @Tiffany05Brisco gave a great talk at group meeting on good habits for Scientific Record Keeping. @UTSWGradSchool @UTSWScience @UTSWMedCenter

This week in #ClassicsFriday, grad student Nate Schmitt @callmefortuNate discussed the groundbreaking synthesis of Strychnine from G.O.A.T. Woodward (Classics in Total Synthesis, Nicolaou and Sorensen): pubs.acs.org/doi/10.1021/ja… What’s your favorite total synthesis by Woodward?

Our lab started a new activity #ClassicsFriday! We’re going through Classics in Total Synthesis (Nicolaou and Sorensen) chapter by chapter. This week we discussed Corey’s groundbreaking synthesis of the Prostaglandins (1969): pubs.acs.org/doi/10.1021/ja… What’s your favorite classic…

Thanks Joerg Schlatterer and Helina Kebede for organizing a great ACS PRF Career Panel! We had a lot of fun answering questions from aspiring young scientists. @AmerChemSociety

Prof. Amos B. Smith developed this beautiful annulation sequence en route to the total synthesis of the cylindrocyclophane natural products. What is the mechanism of the reaction sequence?

Our lab recently discussed the impactful career of Thomas R. Hoye @UMNChemistry! Here are some papers: pubs.acs.org/doi/10.1021/bm… nature.com/articles/natur… nature.com/articles/natur… pubs.acs.org/doi/10.1021/ja… pubs.acs.org/doi/10.1021/ac…

Prof. Mateo Alajarin @alajamat developed and studied this beautiful cyclization that proceeds with ethylene extrusion. That’s the only hint we will give you. What is the mechanism of the reaction?

We enjoyed hosting our friend Joe Fox @FoxGroupUD @UDelaware for a seminar during our joint 2025 Chemistry-Biology Interface T32 Symposium between @UTSWMedCenter and @UMich! Thanks Grad student Lauren Duncan @ledwards31 for organizing the event.


Our lab recently discussed the career of our good friend Joe Fox @FoxGroupUD @UDelaware! Here are some papers: pubs.rsc.org/en/content/art… pubs.rsc.org/en/content/art…

You’re going to love this mechanism! Louis Barriault reported a beautiful cationic reaction cascade to access highly functionalized bicyclo[m.n.1]alkanones. What is the mechanism of the reaction?
![TambarLab's tweet image. You’re going to love this mechanism! Louis Barriault reported a beautiful cationic reaction cascade to access highly functionalized bicyclo[m.n.1]alkanones.
What is the mechanism of the reaction?](https://pbs.twimg.com/media/GtS87rUWQAARpP7.jpg)
Grad student Lauren Duncan @ledwards31 gave a great talk at group meeting on Rigor and Reproducibility. We learned about Casadevall and Fang’s 5 Pillars of Rigorous Science.

This might be one of the coolest Name Reaction Mechanisms we have ever seen! An interesting thermal transformation was initially described by Doering and Goldstein and then studied in detail by Müller. What is the mechanism of the reaction?

Our lab recently discussed the illustrious career of the late Robert K. Boeckman, Jr. @URochesterChem @UofR. Here are some papers: pubs.acs.org/doi/abs/10.102… pubs.acs.org/doi/10.1021/ja… pubs.acs.org/doi/10.1021/ja… mdpi.com/1999-4923/10/3…

Congratulations grad student Tiffany Brisco @Tiffany05Brisco for UTSW GSO Outreach Award in recognition of contributions to serve young scientists in @UTSWMedCenter community and Dallas-Fort Worth metroplex! @UTSWScience @UTSWGradSchool

Thank you @ambeedinfo for sponsoring the 2025 UTSW-Ambeed Symposium on Synthesis! We had a great time hosting Christopher Vanderwal @UCIrvine and Regan Thomson @NUChemistry. And we heard a great seminar from Ankush Banerjee of Myles Smith’s Lab @UTSWMedCenter @UTSWScience.



Congratulations Ustina Grybchuk on a great semester in the Lone Star ISM Independent Study & Mentorship Program for stellar high school students in Frisco! We are very proud of you!

Direct reductive amination of amides with sulfonamides at RT? ✅ Zr-catalysis makes it possible—mild, efficient, and selective for late-stage monoalkylation. Check out the latest paper from our group @BaylorCBC now available online @ACSCatalysis! pubs.acs.org/doi/full/10.10…
Photocatalytic Synthesis of Substituted 2-Aryl Morpholines via Diastereoselective Annulation | Journal of the American Chemical Society @UTSWMedCenter @UTSWNews @TambarLab pubs.acs.org/doi/10.1021/ja…