TransplantDirect

The June issue of @TXPDirect is jam-packed with useful information for our diverse international transplantation readership. We welcome you to visit our Transplantation Direct website for full details in open-access. #OpenAccess #TransplantTwitter bit.ly/TXDissue

New strategy for GvHD in pediatric small intestinal transplant: Switching from immunosuppression intensification ➡️ reduction significantly improved survival. Linked to changes in T-cell chimerism—possibly tipping the balance toward host-versus-graft tinyurl.com/yjaescwc

DBD to DCD donation pathway. Among eligible brain-dead donors, some proceed via circulatory death—mostly due to family wishes to witness asystole. Outcomes? Comparable graft survival, with reduced delayed graft function vs standard DCD tinyurl.com/y7dky84x

3D laparoscopic ileal resection shows promise in living donor small bowel transplantation! In 7 parental donors, this minimally invasive approach led to safe recovery, normal bowel function, and high donor satisfaction at 6 months #TXPforAll tinyurl.com/5n8w7ytw

A stable and feasible baboon model for orthotopic liver transplantation has been established—overcoming limitations of existing primate models and paving the way for translational advances in ischemia- and tolerance-free transplant research tinyurl.com/yjtxuakn

GREAT CASE REPORT by Chen, reported the successful treatment of post-transplant thrombotic microangiopathy in a simultaneous pancreas-kidney recipient with plasmapheresis, #eculizumab, and a CNI/mTORi-free regimen. tinyurl.com/ajv6nf79

Most popular paper this month! In a national kidney transplant cohort (n = 242K), obesity defined by both BMI and BSA was linked to significantly higher risks of graft loss and delayed graft function. #KidneyTransplantation #Obesity #TXPforAll #OpenAccess tinyurl.com/m8hzz9ac

In lung transplant recipients, even small gains in physical function (via LT-VLA) linked to better quality of life, lower CLAD risk (↓13%), and reduced mortality (↓19%). LT-VLA may be a simple yet powerful tool for post-transplant monitoring tinyurl.com/mr3hexy4

Check this study of around 242K kidney transplants, where obesity defined by both BMI & BSA was linked to higher graft loss & delayed graft function vs BMI alone. Dual-parameter obesity may better flag high-risk recipients tinyurl.com/d688kmzp

This study of 1803 kidney transplant recipients, where 35% showed nonadherence in the first year—linked to worse graft outcomes. Psychiatric history and prior nonadherence were key risk factors. Simple monitoring can help flag high-risk patients tinyurl.com/yc7ckmfp

This study by Baan et al. reports that kidney-derived urinary extracellular vesicles (KD-uEVs) are promising noninvasive biomarkers for the early diagnosis of acute rejection. #Transplantation #TXPforAll #OpenAccess tinyurl.com/m3kh3dde

A decade of research reveals growing global collaboration—but major gaps remain. Only 2.2% of potential institutional links explored. LMICs still underrepresented. Time to foster inclusive, equitable partnerships in transplantation science. tinyurl.com/yxxvtp4d

Kidneys from donors with acute kidney injury requiring dialysis (AKI-RRT) can be safely transplanted with outcomes comparable to AKI donors not on dialysis. Careful selection expands the donor pool without compromising graft survival. @ucdavis #TXPforAll tinyurl.com/mr3njaf3

Patient-reported physical functioning after lung transplant predicts better quality of life, lower CLAD risk, and improved survival—independent of lung function. @lseijoMD reports that LT-VLA may be key for post-transplant monitoring. #TXPforAll tinyurl.com/3mn84e95

After lung transplant, feeling stronger matters: Study by @lseijoMD reports that better patient-reported physical functioning is linked to higher quality of life, and lower risk of lung complications and death—regardless of lung test results. #TXPforAll tinyurl.com/3xt4k7u2

In kidney transplant patients with severe gout, this study by Dalbeth et al. found that 6 months of pegloticase treatment nearly eliminated uric acid deposits. But unlike others with gout, bone healing was limited. @UoAOnline #TXPforAll tinyurl.com/2v8w4vsn

Rethinking obesity in kidney transplant candidates! This study of 240 kidney transplant recipients shows that using both BMI and body surface area identifies patients at greater risk for graft loss and delayed function — better than BMI alone. #TXPforAll tinyurl.com/yxvkzrcx

Game-changer in complex multi-organ transplants! High-risk series of simultaneous cardiothoracic surgery and liver transplant, no single mortality was reported. Incredible work by @beatrice_cz & colleagues with normothermic machine perfusion #TXPforAll tinyurl.com/2v7yckkv

A modified radial forearm flap technique now enables fast, safe, and reproducible sentinel skin flap (SSF) procurement during organ donation procedures — even by non-expert surgeons. A step toward better rejection monitoring.#TXPforAll #OpenAccess tinyurl.com/5yw3aexy

Kidney-derived urinary extracellular vesicles rise show promise as noninvasive #biomarkers to distinguish acute rejection (AR) from acute tubular necrosis (ATN). @BaanCarla TXPforAll #OpenAccess #KidneyTransplantation #Biomarker tinyurl.com/39kuynjd