Sylvan Baca MD PhD (Hiring!)
@SylvanBacaLab
GU oncologist and computational epigenomics enthusiast at @DanaFarber, Assistant Professor @harvardmed
We're #hiring a computational #postdoc! PhD in computer science or other quantitative field? Join our mission: push the boundaries of precision #oncology with computational #epigenomics and #AI. careers.dana-farber.org/job/postdoctor… Please RT!

Thank you @DanaFarber_GU! Congrats to @JeremiahWala and @bill_lotter, and my deep gratitude to the Wong Family for helping us improve cancer care!
Two Lank Center faculty that received the Wong Family Award in Translational Oncology for FY25 were recently highlighted by the institute. Congratulations to @SylvanBacaLab and @JeremiahWala! linkedin.com/posts/dana-far…
Excited to share this molecular case report in @Nature_NPJ led by @KarlSemaan and @RashadNawfal. I expect to see more of this rare resistance mechanism with advances in AR-targeting therapy. Great colab with @Jberchuck, @DrChoueiri, and #MattFreedman. nature.com/articles/s4169…
1/ Happy to share our latest piece in @Nature_NPJ precision oncology: "Plasma epigenomic profiling reveals treatment-emergent squamous transformation in prostate cancer". Work co-led with @KarlSemaan with great mentorship from @Jberchuck @SylvanBacaLab #MattFreedman @DrChoueiri…
Great poster presentations at #AACR25 by @zezhangzzz and @marc_eid on computational methods for epigenomic liquid biopsy and circulating signatures of pancreatic cancer subtypes.


So excited for you, @KarlSemaan and thrilled you'll be staying in the neighborhood at @BrighamMedRes. It's a testament to the incredible hard work you've put in over the last two years in lab. Looking forward to collaborations to come!
I am absolutely thrilled to have matched at @BrighamMedRes @BrighamWomens for internal medicine residency! Incredibly grateful to my amazing mentors, colleagues, and friends who have supported me throughout this journey @SylvanBacaLab #MattFreedman @DrChoueiri #Match2025
So proud of mentees @RazaneHChehade, @KarlSemaan, @RashadNawfal, and @marc_eid for their fantastic talks at ASCO #GU25. Their translational projects should lead to better outcomes for patients with kidney or prostate cancer.

Great work, @RashadNawfal!
Tour de force presentation on HIF2A expression and clinical outcomes in ccRCC and sarc-Rcc by @DanaFarber_GU superstar @RashadNawfal! @SylvanBacaLab @DanaFarber #FreedmanLab
Beautiful work on profiling prostate cancer epigenomes from plasma to reveal clinical subtypes: pubmed.ncbi.nlm.nih.gov/39652574/ Congratulations, @researchwyatt, @TakedaDavid, and team! Still amazes me what a detailed view of gene regulation in cancer cfChIP-seq provides.
The lab celebrated a wonderful year with an Italian cooking class. Turns out that among our talented physicians and scientists we also have some gourmet chefs!


Congrats @allisonoconn! Dana Farber is lucky to have you join!
Words cannot describe the feeling of opening this email. I’ve been working towards being an oncologist for over a decade. Not only do I get to be one, I get to train at an incredible institution surrounded by brilliant physicians and scientists. How lucky am I. @DanaFarber
Honored to be awarded best poster at the @isliquidbiopsy #ISLB24 Annual Congress for our work using a novel epigenomic liquid biopsy platform to detect PSMA expression and predict Pluvicto response in mCRPC. CC: fantastic collaborators @PrafulRavi1 @HJacene @Precede_Bio
Beautiful work, @zezhangzzz !
Excited to share our @Nature_NPJ paper on methylation cytometry blood profiles associating with immunotherapy response in head and neck cancer. Kudos to the team @DartmouthCancer @DanaFarber @brockclarke @lsalas_epigenet @KartikSehgal_MD @DrHaddadRobert!🧬nature.com/articles/s4169…
Join us! Our division (@DFCIPopSci) @DanaFarber and @harvardmed is hiring at the assistant/associate prof level. Under the fantastic leadership of @VanAllenLab, this division has been such a supportive place to launch a career in cancer research.
Hi folks, we have new faculty open search in @DFCIPopSci @DanaFarber @harvardmed, seeking folks interested in launching an independent research program across our very diverse and interdisciplinary set interests! See link for more info: careercenter.asco.org/job/7622758/as…
Thank you, @DanaFarber! I'm so grateful and excited to use this award to push the boundaries of epigenomic liquid biopsy to improve cancer care.
Congratulations to Drs. Sylvan Baca (@SylvanBacaLab) & Jeremiah Wala (@JeremiahWala) on receiving 2024 Wong Family Awards from @DanaFarber! These awards support the careers of young investigators and furthering translational oncology or biotechnology development at DFCI.
Dr. @KarlSemaan is a physician-scientist trained @SylvanBacaLab, #FreedmanLab @DrChoueiri Labs for 2 years (Comp Bio), >20 original pubs, team player and... today @TheLancetOncol 1st author. IM programs should take note of this winner. @StoriesImg @IMG_Oncologists…
Hello #MedTwitter #MedX! My name is Karl Semaan, #IMG from Lebanon @USJLiban, postdoctoral research fellow and computational epigenomics enthusiast @DanaFarber @harvardmed I am excited to be applying to #InternalMedicine for the #Match2025! AAMC ID: 16429630 #InsideTheMatch
🎉Congrats rising star 🌟🌟🌟 @KarlSemaan , MD and post-doc from @DanaFarber_GU for his great poster at #ESMO24 🌟✨🌟 @yekeduz_emre @DrChoueiri
Determination of tumor PSMA expression in #ProstateCancer from blood using a novel epigenomic liquid biopsy platform. Presented by @PrafulRavi1 @DanaFarber_GU. #ESMO24 written coverage by @zklaassen_md @GACancerCenter > bit.ly/3ZJ1Fjd @myESMO
Understanding #KEYNOTE564: Pembrolizumab’s role and post-adjuvant therapy for #RCC patients. @KarlSemaan & @TalalZarif1 join @zklaassen_md in this discussion of the evolving landscape in RCC treatment. #WatchNow > bit.ly/4e1l9mN @DanaFarber
Congratulations @VanAllenLab!
Eliezer “Eli” Van Allen, MD (@VanAllenLab) has been named the inaugural incumbent of the Chandra Nohria Family Chair for AI in Cancer Research @DanaFarber.
Huge congrats to @TalalZarif1 and @KarlSemaan and all team for this great and timely paper presenting a real-life data in this hot-topic! @OncoAlert @DrChoueiri @DrDanielHeng @IMDConline @fmassari79 @DrRanaMcKay @montypal @SylvanBacaLab @EbrahimiHedyeh @TiansterZhang @marc_eid…
1/ 🚨 Just in @EUplatinum , our study on first-line systemic therapy following adjuvant immunotherapy in renal cell carcinoma. Effort co-led with @TalalZarif1, with amazing mentorship from @DrDanielHeng @DrChoueiri sciencedirect.com/science/articl… @DanaFarber_GU @YaleMed @OncoAlert
Congratulations to @danafarber researchers Erin Parry, MD, PhD (@ErinMParry), Lachelle Weeks, MD, PhD (@Lachelle_Dawn), and Megan Insco, MD, PhD, who were awarded the Damon Runyon Clinical Investigator Award. Read more ms.spr.ly/6013ll1QP