Sreelakshmi C
@SreelakshmiC2
PKD Reserach | Kidney Injury | Nephrology | Microscopy | #phdstudent #UAB | live your life to the fullest
I had the incredible honor of spending time with Dr. Victor Ambros, co-recipient of the 2024 Nobel Prize in Physiology or Medicine. From sharing meals and meaningful conversations to introducing him on stage at UAB. Grateful beyond words! #NobelPrize #UAB @UABCDIB


🙏 Thank you @JASN_News for inviting me to contribute in the new format ‘innovator corner’. 💡Here I discuss how we came to the discovery of the Warburg effect and metabolic reprogramming in PKD. 💊And our attempts at translating this discovery into a therapy for patients.
The work of Dr. Alessandra Boletta and her group has uncovered a profound metabolic reprograming in PKD, limiting flexibility into using different sources of carbon. In this article, Dr. Boletta asserts that as such, the glycolysis inhibitor 2DG holds great promise as a possible…
The Song Lab at UAB’s School of Medicine invites applications for a gap year research position! Interested applicants can send their CV and statement to Dr. Jack Song at [email protected].
Combined lineage tracing and scRNA-seq reveal the activation of Sox9+ cells in renal regeneration with PGE2 treatment onlinelibrary.wiley.com/doi/full/10.11…
Show me a better come back video than this I will wait 🇮🇳 #Chandrayaan3 #IndiaOnTheMoon
Chandrayaan-3 Mission: 'India🇮🇳, I reached my destination and you too!' : Chandrayaan-3 @Chandrayaan3 has successfully soft-landed on the moon 🌖!. Congratulations, India🇮🇳! #Chandrayaan_3 #Chandrayaan3Landing #Chandrayaan3 #MoonLanding #india #VikramLander
@AJPRenal #ArticlesinPress: @2divyabhatia & Choi discuss the roles of #autophagy & #mitophagy in the #kidney in regulating inflammatory responses & during various pathological manifestations. ow.ly/ffRZ50OmQ9k @WeillCornell #KidneyInflammation #AcuteKidneyInjury #CKD
Now in print! 📗 Single cell RNA-seq and functional assays to examine monocyte-endothelial cell interactions in CKD. Transatlantic collaboration 🇮🇪🇺🇸 !!! @sarahcormican91 @mattgriffinneph @uniofgalway @WUTransplant
CVD in patients with CKD is linked to increased circulating intermediate monocytes (IMs). This study found CKD is linked to an increase in a distinctive proinflammatory IM subpopulation & abnormalities of monocyte migration & endothelial adhesion bit.ly/JASN083
This analysis of genome organization and gene activity with single-cell resolution using lineage tracing and single-nucleus multiomics offers new insight into regulation of renal injury repair bit.ly/JASN057 @HumphreysLab
Protocol: 1.Nasal swab into 100ul RNA shield on D2 2.RNeasy RNA isolation 3.iScript RT w/ AAACAGTTGCTGGTGCATGT 4.Phusion (touchdown from 65-62° 30” extension w/ TTTAACGCCACCAGATTTGC and CAGTTGCTGGTGCATGTAGAA) 5.Sequence w/ TGCTTGGAACAGGAAGAGAA and TGCATGTAGAAGTTCAAAAGAAAG
So, our Spike contained mutations S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, R452Q, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H. It's missing F486V and has Q493R and R452Q so it's NOT BA.5 (the most common guess). It was BA.2.12.1, instead! Pileup below: