Sondos Zayed

Among adults with spinal cord injury, intermittent catheterization was associated with >2x the likelihood of regaining volitional bladder control within one year compared to indwelling catheterization. ja.ma/44FZYVH

🚨ACCORD Trial🚨 Resected Extrahepatic CCA or Gallbladder CA 🔍Randomized Adjuvant CRT + Camrelizumab vs Observation 🔥Whopping improvement in OS and RFS with CRT + ICI with persistent separate at tail of the curve!!! tinyurl.com/64yc3uum @JAMAOnc

🚨 Exercise is no longer optional, it is essential! One of the most impactful studies at #ASCO25 🏃‍♂️ The #CHALLENGE trial (LBA4319) proves that structured exercise after chemo in stage III colon cancer is not just lifestyle—it’s life-saving. 📊 5y DFS: 80.3% vs 73.9% ❤️ 8y OS:…

🚨Update Randomized Trial: Significantly Better KPS & Cognitive Function with SRS compared to HA-WBRT for 5-20 brain mets 🚨🚨🚨

A standing ovation for #CHALLENGE trial at #ASCO25 - first in world to definitively show exercise reduces recurrence and improves survival: “For every 16 people, exercise prevents 1 person from recurrent/new cancer” “For every 14 people, exercise prevents 1 person from dying”

Most viewed this week from @JAMAOnc: Viewpoint discusses how "skimming the median" can exaggerate survival gains in clinical trials, underscoring the need to critically evaluate Kaplan-Meier curves alongside hazard ratios. ja.ma/45zBluy

🚨SPRING-01🚨 🔍Locally Advanced Rectal Cancer RCT: 25 Gy x 5 ➡️ CAPOX +- Sintilimab 🔥+ Sintilimab demonstrated: ✅⬆️pCR 59% vs 33% ✅No significant adverse surgical or safety signals Time to explore with organ preserving approaches⁉️ #ASCO25

What if this was a drug ?🙂 🆕 NEJM | June 2025 🎯 CHALLENGE Trial: Structured exercise after adjuvant chemo in colon cancer 📦 RCT | n=889 | Median FU: 7.9 yrs 🟠 3-yr structured aerobic program vs health ed alone 📈 Primary Endpoint: Disease-Free Survival (DFS) 🔹 HR 0.72…

Viewpoint discusses how "skimming the median" can exaggerate survival gains in clinical trials, underscoring the need to critically evaluate Kaplan-Meier curves alongside hazard ratios. ja.ma/4jePW1F

For patients with esophageal ca who achieved complete clinical response after chemo/RT, esophagectomy vs surveillance? Phase III randomized SANO showed no difference in overall survival. Organ preservation/quality of life are crucial for most of our patients, MDT is the key!

Our critical review of contemporary radiation therapy for locally advanced #pancreaticcancer is in press @IJROBP 🙌 @JonAshmanMD @KrishanJethwa @jordankhar @eugenekoay @ebludmir @EricMillerMDPhD @RadDocMReyngold @NiuSanford @Dan_ChangMD redjournal.org/article/S0360-…

🚨 Hippocampal-Avoidance PCI: Game-Changer or Cognitive Mirage? 🚨 @OncoAlert 🔎 Objective •Evaluate the impact of HA-PCI on self-reported cognitive function and 🧠 metastases risk in SCLC 👥 🧪 Methods •Pooled data from two phase III RCTs (NCT01780675 & PREMER) •Randomized…

Management of Locally Advanced Rectal Cancer: ASCO Guideline | @JCO_ASCO ascopubs.org/doi/full/10.12…

We also consider SBRT for oligoprogression in HCC b/c: -high local control -usually low toxicity -allows pt to stay on 1st line chemo controlling non-progressive tumors -saves 2nd line in case of future more widespread dz This is a nice paper lending support to that strategy

How to update publications and abstracts in your CV These are the most time-efficient ways to keep your publications updated and organized for academic medical centers:

Meta‐analysis of randomized controlled trials of external‐beam radiation versus TACE for HCC Pooled analysis of 3 RCTs 💥Compared with TACE, EBRT yields superior local control and PFS early and intermediate stage HCC acsjournals.onlinelibrary.wiley.com/doi/full/10.10…

Yes, I made a similar pt in my talk re: TOPGEAR. Differences in treatment effect by primary tumor location.

Long awaited practice-changing results from ph 3 CM8HW now out in @TheLancet. Nivo/ipi sign better than nivo mono in dMMR mCRC @sara_lonardi1 @bmsnews #GI25 thelancet.com/journals/lance…

Novel primary percutaneous stenting method for hilar CC presented by Dr Koerkamp @ASCO #GI25 Website describing technique below so your interventionalist can implement it tomorrow! Promising Ph2 results with 0% cholangitis. RCT ongoing in Netherlands. teslastudies.wordpress.com

Dr. Koerkamp emphasizes that biliary drainage is key for BTC (and makes the case for percutaneous stenting). #GI25