Shifra Lansky
@ShifraLansky
Assistant Professor at Weizmann Institute of Science. Structure and Dynamics of Membrane Proteins. Cryo-EM, HS-AFM, MD simulations, X-ray Crystallography.
I have just opened my lab at the Weizmann Institute of Science, Department of Chemical and Structural Biology, and am looking for students! Please share! :) For more details, check out my website: weizmann.ac.il/CSB/lansky
This is the most Israeli thing I’ve seen. Taken at the Weizmann Institute of Science, following the Iranian attack.
Check out our new paper in @NatureComms! We report a much improved structure of the TRPV3 pentamer, analyzing its high permeability capabilities and its mechanistic ability to reversibly transition to and from the canonical tetrameric state. @ScheuringLab nature.com/articles/s4146…
Super exciting to share that our latest methodology development with @ScheuringLab just came out today in @NatureComms! In this work, we introduced a method to construct (pseudo-)3D AFM densities (3D-LAFM), and use these densities as external... nature.com/articles/s4146…
Our study with @rogoulenko in @NAR_Open shows #DNA flexibility impacts protein binding. Despite kinetic challenges, evolution ensures proteins effectively target and bind DNA. Check out Daniel Philosoph's cover art, hand-painted with real brushes! #ProteinDNA #ProteinStructures
This is fantastic! Variability of membrane protein oligomeric state may be much more common. The structural biology approach, investigating highly purified samples, could only result in finding very homogeneous populations. Cannot wait to read the paper and see more! ⭐️⭐️⭐️
We have a new paper for you: “Structure of tetrameric forms of the serotonin-gated 5-HT3A receptor ion channel”. Here we found that the prototypical pentameric ligand gated ion channel can form stable tetramers and characterized it with cryo-EM/ET and molecular simulations.
rdcu.be/dPbig The cyanobacterial protein VIPP1 forms ESCRT-III-like structures on lipid bilayers Free link: rdcu.be/dO2GF Collaboration with @bengeliscious, Michael Schroda, and Christoph Haselwandter labs.
Thrilled to announce our latest work in @NatureSMB on HS-AFM single-molecule structural biology with @ScheuringLab ! Marching towards our long-standing goal, we've directly linked the conformations of a single molecule to its instantaneous activity... nature.com/articles/s4159…
HS-AFM single-molecule structural biology uncovers basis of transporter wanderlust kinetics - now out @NatureSMB - free link rdcu.be/dE0wf @YiningJiang @BoudkerLab @MBiophys_WCMSKI @WCMResearch @WCMAnesthesia Conformational landscape of a single molecule
Understanding the structural dynamics of ion channels will help researchers target them for therapeutic applications. @seanderson63 reports on how @ScheuringLab @WeillCornell used microscopy techniques to probe pore dilation in the TRPV3 channel. ow.ly/ss0750QpjHL
A monumental work by John Ingraham and team @generate_biomed on Chroma✨ for protein design. Congrats!!! 🔥🎉🔥🎉 So excited to see it out, fully open source and with experimentally validated xtal structures! Perhaps cryo-EM of the giant complexes next? generatebiomedicines.com/chroma
4/n: The API is meant to be very clean and easy to use. Want to get started quickly sampling a simple backbone 200 amino acids? It's as straight-forward as:
We studied, using HS-AFM, a unique protein, Bcs1. A transmembrane protein with a heptameric (!) AAA-ATPase ring, that transports a folded protein across the inner mitochondrial membrane. @yangang61116459 @WCMAnesthesia Free: rdcu.be/dojkc nature.com/articles/s4146…
Excited to announce that my paper from Scheruing lab @ScheuringLab has been published in Nature Communications! Thanks to all the authors @YiningJiang , Jingyu Zhan, and Di Xia. A concerted ATPase cycle of the protein transporter AAA-ATPase Bcs1 disq.us/t/4jkjnho
In this week’s Editors’ Choice piece, we highlight the work of @ShifraLansky, @ScheuringLab and colleagues in @Nature, showing that the ion channel TRPV3 switches between tetrameric and pentameric states. Read a summary in #ScienceSignaling: scim.ag/4cs
HS-AFM movie of a tetramer-to-pentamer transition: Protomer diffusing in the membrane and inserting a tetramer to result in a pentamer. Pentamers have an estimated lifetime of ~3 minutes only.
Study sheds light on how ion channels work in cell membranes, pointing to potential new ways for improving the delivery of drugs in the body and treatment of diseases, according to a team led by Dr. Simon Scheuring (@ScheuringLab) of @WCMAnesthesia. bit.ly/45IrCPr
It is well established that proteins in the TRP family of ion channels assemble from four subunits. But do they always do this? A five-subunit structure has now been observed, and might be involved in channel regulation. go.nature.com/3sBvHa0
Using HS-AFM dynamic imaging we discovered among canonical tetrameric TRPV3 channel a small population of channels with non canonical pentameric assembly. The pentamers have an estimated lifetime of only ~3 minutes.
We are very proud! In this work we discovered a pentameric TRPV3 channel! @ScheuringLab @CrinaNimigean @YuanLabSinai @ShifraLansky @_Jingying @labnavid @YiningJiang @WCMAnesthesia @WCMResearch @MBiophys_WCMSKI