Sebastian Barthel

@SebBarthel

Postdoctoral researcher @erblabs (MPI Marburg)

Joined January 2018

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I am happy to share our pre-print on the genetically encoded control of in vitro DNA replication in the PURE system, including data comparing in vitro system setups and highly active phi29 DNAP mutants. Check it out! A big thank you to everybody @erblabs! t1p.de/e4yhl

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Sebastian Barthel@SebBarthel · Sep 30

I am pleased to share the peer-reviewed version of our manuscript on in vitro transcription-based biosensors and their application for in vitro pathway prototyping: doi.org/10.1093/synbio… Thanks to everyone involved in this work for great teamwork, support and guidance! @erblabs

SebBarthel's tweet card. Abstract. In vitro metabolic systems allow the reconstitution of natural and new-to-nature pathways outside of their cellular context and are of increasing

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Sebastian Barthel@SebBarthel · Apr 29, 2024

I am very happy to share our pre-print on the prototyping of a complex enzyme cascade (the CETCH cycle) using in vitro transcription-based (ROSALIND) biosensors. Thanks to everybody involved. We are looking forward to your feedback! @erblabs doi.org/10.1101/2024.0…

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Sebastian Barthel@SebBarthel · Nov 21

New in @EMBOjournal, we studied the evolution of essentiality in Form I Rubisco. While @KaHochberg nicely summarizes the evolutionary implications of our work, let me summarize some of the cool biochemistry surrounding it. doi.org/10.1038/s44318… 🧵

GGeorg Hochberg@KaHochberg · Nov 21

New paper from us and @erblabs by @schulluc : embopress.org/doi/full/10.10…. It's about the evolution of essentiality. This question has fascinated me for a long time: How does a component that was previously unnecessary for some function become essential for it?

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