Sean Pitroda, M.D.
@SeanPitroda
Radiation oncologist & cancer biologist @UChicago @LudwigCancer investigating oligometastatic disease & interplay between radiotherapy & immunotherapy
🧵1/ Tumor aneuploidy—long viewed as a hallmark of cancer—is emerging as a key biomarker of immune resistance. In our latest @NatureGenet Perspective, we explore how aneuploidy can guide immunotherapy decisions and shape future treatment strategies. 🔗 doi.org/10.1038/s41588…
UChicago is recruiting for a faculty radiation oncologist position. We'll be meeting candidates at ASTRO 2025. Check out our posting: careers.astro.org/jobs/view/facu… #radonc #ASTRO
New study from @rweichselbaum and team show high-dose radiation triggers amphiregulin, a protein that weakens immunity and fuels distant cancer spread—pointing to new strategies for blocking its effects. @SeanPitroda @AndrasPiffko @UChicagoRadonc @Nature ow.ly/HgVU50Wn6ZY
💫🌟🔬 Facts and Hopes in Radioimmunotherapy of Oligometastatic Disease🌟💫 by @DrHuangDQ @SeanPitroda @rweichselbaum 📌 @CCR_AACR @OncoAlert 🟢 The oligometastatic state challenges the notion of metastasis as incurable 🟢 SBRT + immunotherapy may offer long-term control or cure…
Congrats @rweichselbaum and UChicago collaborators on an amazing paper in Science Advances! science.org/doi/10.1126/sc… @UCCancerCenter @UChicagoMed
Online Now: The dark side of radiotherapy dlvr.it/TLk3c8
Check out the excellent perspective published by Sean Pitroda, MD, and colleagues in @NatureGenet, highlighting how high aneuploidy scores predict immunotherapy response and can help guide personalized cancer treatment. @UChicagoRadonc @UChicagoMed ow.ly/bJ7K50WkwMf
📢 New in Cancer Cell: Radiotherapy is essential for local control—but can it unintentionally accelerate growth of distant metastases? We examine how RT-induced EGFR signaling and immune modulation may fuel metastatic progression. 🧠🧬🔬 Read: doi.org/10.1016/j.ccel…
10/ Read the full Perspective by Daniel Huang, @liamspurr, @rweichselbaum, and @SeanPitroda 👉 doi.org/10.1038/s41588… Let’s bring tumor aneuploidy from bench to bedside. #oncology #immunotherapy #radiationoncology #precisionmedicine
11/ Special thanks to @UCCancerCenter @UChicagoMed @UChicago @UChicagoRadonc @Ludwig_Cancer @LUNGevity
12/ Also, thanks to @UChicagoMed for highlighting our work! uchicagomedicine.org/forefront/immu…
🌟 In a new study, Huang et al., emphasizes on combining immunotherapy with radiation that may overcome therapy resistance in patients with high aneuploidy scores, offering a new strategy for personalizing therapy. @SeanPitroda @UChicagoRadonc @NatureGenet nature.com/articles/s4158…
Check out our new perspective in @NatureGenet exploring the role of #aneuploidy in predicting outcomes following treatment w/ checkpoint inhibitors & opportunities for therapeutic interventions @SeanPitroda @rweichselbaum @UChicagoRadonc @UCCancerCenter nature.com/articles/s4158…