Schizophrenia International Research Society
@SIRSGlobal
SIRS mission is to bring together researchers from across the world who work on schizophrenia and other related disorders
💡 New Findings in Clozapine Pharmacokinetics A recent study found a positive correlation between the clozapine concentration-to-dose (C/D) ratio and the neutrophil-to-lymphocyte ratio (NLR), which is a marker of inflammation. Results suggest that subclinical inflammation during…
Semaglutide for clozapine-treated patients with schizophrenia - The Lancet Psychiatry Led by Prof Dan Siskind, this paper reports encouraging results from the first trial of semaglutide (Ozempic) in people on clozapine, with no evidence of negative impacts on clozapine levels or…
🌟 New findings on trauma and psychosis A large-scale longitudinal study of 970 individuals hospitalized for psychotic symptoms shows that Adverse Childhood Experiences (ACEs) predict poorer social functioning and higher levels of depression, anxiety, and substance misuse over…
🧠 New insights into affective psychosis and the hippocampus A new study found that individuals with affective psychosis show reduced posterior hippocampal volume, unlike the anterior-first pattern seen in non-affective psychosis. A higher prevalence of incomplete hippocampal…
🇺🇸Happy Fourth of July to our members in the USA! Wishing you a joyful and safe Independence Day celebration. Please Note: Our office will be closed on Friday, July 4th, in observance of the holiday. 🎆
Schizophrenia Recovery Book 📘 Written by someone who’s lived it, James McLure shares his powerful journey through schizophrenia and depression in Eight Stones: My Journey Through Schizophrenia and Depression. A story of transformation, resilience, and hope for anyone facing…
International Guidelines for the Algorithmic Treatment of Schizophrenia (INTEGRATE) - The Lancet Psychiatry Robert McCutcheon and others led a fantastic effort in creating guidelines for schizophrenia treatment based on an algorithmic logic of decision-making. The guidelines…
A novel discovery platform for targeted drug repurposing: application for psychiatric disorders - ScienceDirect The review, led by Prof Michael Berk, provides an in-depth account of the SYNDICAT program on the discovery, validation and testing of novel pharmacological treatments…
RHA Submissions DUE 20 June: ✔️Only 1 submission per person. 🗓️The Awardee will be selected by 1st of Aug. 🥼A total of $5,000 USD is available to support a research harmonisation group over the two-year period. 👥*Only members of SIRS are eligible to apply.…
What’s the evidence for mindfulness and acceptance-based interventions in schizophrenia spectrum disorders? A recent meta-review of 18 meta-analyses revealed small to large effect sizes across outcomes—including symptomatology, mindfulness, and social functioning. Notably,…
🌀 Have you heard of the “anhedonia paradox” in schizophrenia? It refers to the puzzling phenomenon where individuals report a normal capacity to feel pleasure—yet show reduced motivation to pursue pleasurable activities. New research points to the concept of “positivity offset”…
🚨 The 2025 Research Harmonisation Award (RHA) is open through June 20th! The call is open to proposals for these methods: Diagnosis and Classification. Full award details here: schizophreniaresearchsociety.org/research-harmo…
🚨 The 2025 Research Harmonisation Award (RHA) is now open! 🚨 We're calling for methods (not data analyses) to enable cross-country data sharing & comparison in schizophrenia research. 🧠 Focus: Diagnosis & Classification 👥 Members only – apply for membership first if needed!…
🧠 Exciting news! The ANZJP just published an editorial on SYNDICAT, a major new schizophrenia research program led by Prof. Michael Berk. Backed by $6.5M AUD in funding from NHMRC and Deakin University, officially launch on July 1st! #MentalHealth #Schizophrenia #Research…
REMINDER: SIRS will never contact you from an unknown email address requesting your help or posing as the Society's President. Please be careful when responding to suspicious emails!
Transdiagnostic Neurocognitive Endophenotypes for Schizophrenia, Bipolar I Disorder and a Broad Psychosis/Bipolar I Disorder Phenotype: A Mega-Analysis of Twin and Sibling Data Mega-analysis of 1,050 twins/siblings finds IQ & spatial working memory are transdiagnostic…
Psychosis in dementia affects up to 63% of patients—but often goes under-recognized. A new review by Tampi et al outlines diagnostic challenges, modest efficacy of current treatments, antipsychotic risks and the promise of emerging therapies like xanomeline–trospium. #Dementia…