Ruxandra Teslo 🧬
@RuxandraTeslo
Genomics PhD 🧬 @sangerinstitute | Somatic Evolution in Aging & Cancer | long- form https://www.writingruxandrabio.com/ | Emergent Ventures | views my own
One's 30s are a crucial period for professional advancement. Especially in so-called "greedy careers": those where returns to longer hours are non-linear. But one's mid 30s is also when most women's fertility starts to drop 🧵 worksinprogress.co/issue/fertilit…
There's so much handwaving about how "AI will cure cancer" or "AI will revolution science" What we need are more specific, actionable ideas for how AI could accelerate science & security Dropping next week: @IFP will publish 15 "AI for science" ideas from experts.
I hadn't realized this, but Derek Lowe had written a year ago that Sarepta didn't have strong efficacy data. I haven't looked into this myself. But imo, it kinda proves my point that "overregulation" at the FDA is not so much about approval per se, but the process upstream of it.
A Saturday thought: If the FDA wants to force Sarepta Therapeutics ( $SRPT ) to remove its Duchenne gene therapy Elevidys from the market entirely, it could be a long fight. That the FDA has asked Sarepta to stop shipping Elevidys is unusual; that $SRPT has refused is almost…
Wow – this could become (I think) the first miRNA therapeutic It increases miR‑124 levels – mainly in immune cells miR‑124, in turn, prevents the translation of a range of of inflammatory proteins (STAT3 and IL6R – T cells and MCP‑1 /CCL2 – macrophages)
Abivax $ABVX shares up over 550% as ulcerative colitis drug scores two Phase 3 wins! endpoints.news/abivax-shares-…
Coupling rates and divorce rates are both in pretty obvious decline, at the same time. It's sort of interesting that NYC media runs a lot of essays about how shitty marriage is these days when the real story is that marriage is becoming much rarer and much more stable. Today's…
The new data is in: Divorce probabilities for couples who married more recently start out much lower. Estimates from Yifeng Wan @UVA: ifstudies.org/blog/no-longer…
I can't think of anything in life that is easy and also actually rewarding.
The dichotomy set up here—"is parenting hard, or is it awesome"—presumes a firewall between hard and awesome things. Don't most entrepreneurs say that starting a company is pure hell and also exhilarating and rewarding? I also sometimes sense in these conversations an assumption…
This is horrible, but I wanna understand what the scale of this is. My timeline is now full of "you should get yourself off organ donor lists". I don't believe doctors harvest organs from patients who'd otherwise live at a rate that exceeds 1 in a million.
We should always strive to acknowledge problems and improve. We should also acknowledge when things work. 𝐘𝐞𝐬, 𝐦𝐚𝐧𝐲 𝐫𝐞𝐬𝐞𝐚𝐫𝐜𝐡 𝐫𝐞𝐬𝐮𝐥𝐭𝐬 𝐚𝐫𝐞 𝐫𝐞𝐥𝐢𝐚𝐛𝐥𝐞 & 𝐫𝐞𝐩𝐫𝐨𝐝𝐮𝐜𝐢𝐛𝐥𝐞. nature.com/articles/d4158…
It was actually the non mRNA vaccine from AstraZeneca that was found to have a rare but very serious side effect of blood clots which was recognised and the vaccine since withdrawn. I don't know what this obsession with mRNA is all about.
Everyone is reading it wrong; 86% of graduate degree women who are married the literal 1% top earners…remain working even though they don’t “need” to Red pill guys hardest hit: providing your wife a $650k+/yr lifestyle will NOT satisfy her & the entire framework is wrong (1/2)
And I think that explains this graph: rich men have a massively disproportionate rate of having highly-educated nonworking wives. On its face this is strange-- these women have high earning potential (even though income tax structure penalizes work by the lower earner)!
100% agree endometriosis is a poorly studied and badly treated condition but I'm not sure this 60-80% vs 5-55% success rates are comparing apples to apples (in fact, im pretty sure they're not). There's no age stratification or even breaking down by condition for this NaPro…
A thousand miles from New York City, the place @MadeleineKearns call home, there’s a clinic that vows to help women with ‘unexplained infertility.’ She traveled there last year, in her quest to become a mother. thefp.com/p/what-i-went-…
What is the expected efficacy of Elevydis? This is a letter in STATNews from the mother of a child with Duchenne. If the parents are fully informed, it seems to me like they should have a right to try...
FRODO: What are we holding on to, Sam? SAM: That there’s some good in this world, Mr. Frodo. And it’s worth fighting for.
One of the main themes I didn't really fully internalize at the time was that courage is a scarcest and more valuable resource than intelligence alone. Be a Gryffindor. Unironically.
It's become a mark of sophistication to dunk on Harry Potter, but smtimes things are popular bcs they're good. It's not the best writing stylistically, but it captures something fundamental abt human nature, in a way great stories do.
Do ppl actually use chatgpt as a friend?
I read a lot of science fiction as a kid, so it's kind of a shock that the most prescient novel from my youth was in Harry Potter when a girl gets into infinite text chat with a magic diary that pretends to be a perfect safe boyfriend while it actually sucks out her life force.
This is a great example of bad "parenting automation". Automation reading to ur kid and interacting with them in a deep way? Bad! Automating changing diapers (if it was possible)? Good!
I'm not against all convenience. But reading to your child is a great example -- we introduced a convenient way of occupying kids (iPads), and levels of regularly reading to kids in the UK dropped from 3/4s to 1/2 from 2013-2018.
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