Rick Bright
@RickABright
Practical, Innovative, Hyper-focused on saving lives. Immunologist, Virologist, Pandemic Nemesis. Posts are mine.
The Lancet One Health Commission Report published today. Great honor to be a Commissioner since 2019. The COVID-19 pandemic began soon after the Commission formed & strongly underpins how One Health approaches can help us to leave the pandemic era behind. thelancet.com/journals/lance…
A large number of California dairy farms continue to be unable to clear the virus (see below) and as drought worsens in the valley, we anticipated a tick upwards Two new California Dairy Herds turn positive for Avian Flu Palo Alto FluA remains concerning x.com/JusDayDa/statu…
July 2022 FluA outbreak -First year Birds in North America got Flu July 2023 Nothing July 2024 - Tail end of Year FluA-Never-Went-Away Aug 15th, 2024, FluA arrives in California Dairies July 4th, 2025, FluA from Australia? or FluA returns in Cows, but in farms already infected
Adding to Helen's excellent chart: Below is California as a percentage of herds, including the herds which remain unable to clear quarantine with 100% asymptomatic animals and 2024 vs 2025 (Monitoring Palo Alto for hopefully-soon FluA update) x.com/JusDayDa/statu…
A large number of California dairy farms continue to be unable to clear the virus (see below) and as drought worsens in the valley, we anticipated a tick upwards Two new California Dairy Herds turn positive for Avian Flu Palo Alto FluA remains concerning x.com/JusDayDa/statu…
FluA in Palo Alto Its not H1 Its not H3 Its not H5 with 140 local Dairy Cow Herds infected, its unclear if the two are related. This summer FluA spike is significantly higher than the 2022 summer FluA spike or the 2024 summer FluA spike Its also earlier than last year.
Broadly I agree with @RickABright that we can stop bird flu from becoming a pandemic—but I'll add the caveat that we can't stop it if we don't reform industrial animal farming. Public health measure will take us only so far if tens of millions of farmed animals spread the virus
This is a remarkable evolutionary feat that many want to ignore, or wipe their brow thinking they’ve dodged a bullet. Viral evolution will not reverse. It’ll continue evolving towards a virus that poses increasing risk to humans & animals across the globe. It’s critically…
This is great progress by @DrMakaryFDA @US_FDA and a huge opportunity for organizations w/ promising medicines in the development pipeline w/ potential to address National Priorities. H/t @DrMakaryFDA for driving innovation in this space.
Today, I am pleased to announce that companies may now submit statements of interest for participation in the Commissioner's National Priority Voucher pilot program, which offers drug developers enhanced communication throughout the development process and dramatically shortens…
#USDA reports 2 more #H5N1 #birdflu infected dairy herds in California, bringing the state's total to 770. The cumulative national total is 1,077 herds in 17 states. aphis.usda.gov/livestock-poul…
NVSL has uploaded #H5N1 seqs incl wild birds from 2024 Idaho Dairy & undisclosed w/ PB2 K670R 3 B3.13 sets from CA houseflies col late 2024 Merced A/House fly/California/MCDC/2024 Kings A/House fly/California/KCDB/2024 Fresno Counties A/House fly/California/FCDA/2024
This is a remarkable evolutionary feat that many want to ignore, or wipe their brow thinking they’ve dodged a bullet. Viral evolution will not reverse. It’ll continue evolving towards a virus that poses increasing risk to humans & animals across the globe. It’s critically…
⚠️BREAKING H5N1 BirdFlu has infected 50% more mammalian species over the last year, than over the previous 20 years combined. This study looks at mammalian infections pre and post March 2024. ✴️”By March 2024, at least 48 mammal species had been reported infected by H5N1, with…
Cambodia continues to have strong #OneHealth surveillance and response systems. Coordinated action across human, animal, and environmental sectors is essential to detect #spillover early and prevent wider impacts. #H5N1 #PublicHealth #GlobalHealth #Zoonoses
13th human case of #H5N1 in Cambodia this year: 6-year-old boy from Tbong Khmum province, confirmed on July 21. Exposure likely linked to sick and dead poultry. He is currently in intensive care. #AvianInfluenza #Cambodia #Zoonoses
Live from Wisconsin A state where barns have 12mph constant forced barn breeze, anti-bird-and-flies-air-curtains on all entrances groundwater misting on hot days, almost zero drought and it seems zero Avian Flu Which factor leads to zero flu in milk? All of them or none of them
July 2022 FluA outbreak -First year Birds in North America got Flu July 2023 Nothing July 2024 - Tail end of Year FluA-Never-Went-Away Aug 15th, 2024, FluA arrives in California Dairies July 4th, 2025, FluA from Australia? or FluA returns in Cows, but in farms already infected
HA mutations (1 seq): E2K, D104G, **S110N**, L120M, L131Q, V147M, T211I, V226A, S336N, I526V Ref: A/Astrakhan/3212_cell/2020 2/n
#H5N1 #AvianInfluenza updates Quick analysis of seqs sampled from #HouseFly uploaded to @GISAID from #California (2.3.4.4b B3.13 Collected Oct 2024) PB2 mutations: T58A, V109I, V139I, E362G, K389R, D441N, V478I, V495I, M631L, V649I, K670R, M676A Ref: A/Duck/Guangdong/E1/2012
A piece to the transmission mystery is solved. Not the entire mystery of transmission… but considering Wisconsin Corporate dairies use closed barn 8-12mph constant flow and air curtains to curtail birds AND FLIES… this is a helpful addition to the H5N1 knowledge base.
#H5N1 @CDCgov @USDA House flies have entered the H5N1 sequencing chat. Samples are from CA, last Oct/Nov. h/t @Nucleocapsoid
HA mutations (1 seq): E2K, D104G, **S110N**, L120M, L131Q, V147M, T211I, V226A, S336N, I526V Ref: A/Astrakhan/3212_cell/2020 2/n
⚠️BREAKING First report of the Co-circulation of distinct high pathogenicity avian influenza virus (HPAIV) subtypes ( H5N1/H5N5) in a mass mortality event in wild seabirds and co-location with dead seals in Great Britain 🇬🇧. ✴️ This represents the first recorded instance in GB…
U.S. FDA grants full approval for Moderna's mRNA COVID-19 vaccine for children aged 6 months to 11 years —Reuters
Repeated spillover of HPAI to cattle challenge the food supply system, and there is tremendous benefit to controlling this. Review of HPAI in cattle situation. 👉nature.com/articles/s4429…