Rachael Kretsch
@RachaelKretsch
Biophysics PhD Student with DasLab & ChiuLab. Pairing RNA structure & cryoEM to better understand both! King's College, Science & Security '19 Harvey Mudd '18
Structural biologists expose that many CASP16 predictions, even high scoring ones, are inaccurate in the most functionally relevant regions! Read more insights on functionally relevant features by the expert structure determiners (doi.org/10.1101/2025.0…).
More ROOL structures, with insights into assembly process!
Excited to share our work on the structure of a natural RNA nanocage formed by the ROOL noncoding RNA, originally discovered by Zasha Weinberg and @RonBreaker many years ago. Great collaboration with Xiaobin Ling, Jinbiao Ma, and @KorostelevLab! rdcu.be/erdqY
Nucleic acid assessment for #CASP16 blind competition is out. As in prior challenges #deeplearning for 3D #RNA structure in #CASP16 prediction remains disappointing. doi.org/10.1101/2025.0… 1/N
Are RNA 3D models accurate enough to be biologically useful? #CASP16 experimentalists say: not so much. doi.org/10.1101/2025.0… Thanks for leading this paper @rachaelkretsch @AKryshtafovych! 1/2
Pretty new discovery! 💎 SLAC and @Stanford researchers using cryogenic electron microscopy showed for the first time that large RNA complexes can assemble without the help of proteins, expanding our understanding of RNA folding and function: stanford.io/3GEaHGs