Prostate Cell News
@ProstateCell
An online resource for researchers studying prostate cells and prostate cancer. Part of the @STEMCELLTech Science News service.
This @MolOncology study by Dr. @dl_goode and team redefines focal neuroendocrine differentiation as a distinct #prostate cancer pathology. 馃攷 Discover more: bit.ly/4lWjB1G

Hear from Dr. Cathi Murphey as she discusses the validation of cell isolation technologies for isolating different cell subsets and improving purity for #chimerism analysis in this @STEMCELLTech webinar. 馃ゼ bit.ly/3FCBkvi

Researchers investigated the regulation and function of PD-1 expression in #ProstateCancer and revealed the impact on the tumor microenvironment. 馃挕 Learn more in @CR_AACR: bit.ly/3UhJixT

Scientists engineered an enhanced PSMA/CD3 bispecific antibody by incorporating the extracellular domain of CD80, which provides a co-stimulatory signal to counteract T-cell inhibition in #ProstateCancer. 馃摉 Discover more: bit.ly/46Zp3fD

Dr. Neil Bhowmick and colleagues depletion of glutamine with a cyanobacteria-derived catalytic aptamer blocks FGF8 expression and sensitizes hormone refractive prostate tumors to androgen receptor inhibitors. 馃┖ @CR_AACR | bit.ly/46fHmNo

Today in @NatureGenet! Scientists report a hierarchical network of TFs governed by NKX2-1 in critically regulating chromatin remodeling and driving luminal-to-neuroendocrine transformation in neuroendocrine #ProstateCancer. 馃寪 go.nature.com/4lCMu2N

馃攷 Scientists investigated #androgen receptor involvement in pain sensitivity and sex differences in pain perception. Manipulating androgen signaling in sensory neurons may offer a promising approach to managing mechanical pain. 馃敆 bit.ly/3GvWjR9

馃敩 Researchers created an urinary large extracellular vesicles-centric proteomic approach for early prostate cancer identification. @an_chem | bit.ly/3IsSo8j

馃 The antitumor activity of a 56mer aptamer helped support glutamine as an oncometabolite in prostate adenocarcinoma that can be targeted to sensitize tumors to hormone therapy. @CR_AACR | bit.ly/46fHmNo

A new study led by Dr. Nicolas Herranz (@Niko_Herranz) at @VHIO underscores the potential of CDK4/6i in #ProstateCancer therapy, particularly when administered under biology-driven sequential use of senolytic therapy or PARPi. 馃搶 Learn more: bit.ly/40PWkGe

Scientists in China have shown that TRIM26, an E3 #UbiquitinLigase, drives #ProstateCancer malignancy and may be an attractive target for treatment. 馃ゼ Read the study: bit.ly/40a8KIX

New findings from researchers in China underscore the pivotal role of YY1 in the hypoxia/HIF-1伪 pathway in tumor-associated macrophages and support the targeting of YY1 for treating #ProstateCancer. 馃摎 Read the @NatureComms study: go.nature.com/4eF3C5r

NUSAP1 is a crucial mitotic regulator that plays a significant role in various cancers, including prostate cancer. A new #review discusses the roles and mechanisms of NUSAP1 in human cancers. 馃敆 bit.ly/44DcV1d

New work led by Dr. Jan-Ake Gustafsson at @UHouston shows that #EstrogenReceptor 尾 is critical for maintenance of basal cells in the prostate and controlling prostatic inflammation. Read the @PNASNews study: bit.ly/4eB8CrL

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馃ゼ Investigators demonstrate the feasibility of using predicted structural models for optimizing lead compounds, and HEAL-116 provides a promising avenue for the clinical validation of 3尾HSD1 inhibitors in prostate cancer therapy. @PNASNews | bit.ly/3IpQipq

馃摉 The authors summarize the latest drug treatment strategies and clinical concerns in the management of advanced prostate cancer in Japan, based on the Japanese Clinical Practice Guidelines for Prostate Cancer published in 2023. 馃敆 bit.ly/3TSzQ3z

馃拪 Researchers at @DanaFarber uncovered a common MUC1-C-dependent pathway in treatment-resistant CRPC/NEPC progression and identified MUC1-C as a target for their treatment with a M1C antibody-drug conjugate. @JCI_insight | bit.ly/4lzPH2T

馃搱 Scientists showed that dysregulated ubiquitination and turnover by the cullin 3 ZBTB2 E3 ligase complex induce the upregulation of the short isoform of NSD3, which confers PARPi resistance in prostate cancer cells and #mCRPC samples. @MolecularCell | bit.ly/4lbOXRW

馃К Researchers establish FOXA1 as a multifaceted oncogene, with distinct mutational classes divergently evolving to drive prostate tumorigenesis or therapy-resistant progression. 馃憠 @ScienceMagazine | bit.ly/3Gis4Ng
