Phil Holliger

Winner of the 2024 Researcher of the Year category sponsored by @AstraZeneca at #SciTechAwards is Dr Benjamin Porebski of @MRC_LMB for developing a method that has the potential to transform the discovery of new medicines

We are looking to recruit a tenure track group leader in the field of Chemical/Synthetic Biology (in the broadest sense) to lead a research program within the Division of Protein & Nucleic Acid Chemistry ( jobs.ac.uk/job/DNW809/res… ) at the MRC Laboratory of Molecular Biology (LMB)

New paper from my group rdcu.be/eoaRr "Trinucleotide substrates under pH–freeze–thaw cycles enable open-ended exponential RNA replication by a polymerase ribozyme" in Nature Chemistry — great collaboration with attwaterlab.uk.

Find me now also over at the other place: philholliger.bsky.social

I've started visiting @PhilHolliger lab at @MRC_LMB this week - its been inspiring and challenging in the best way! A short journey from JJ Thomson Avenue (electrons) to Francis Crick Avenue (nucleic acids) :)

So fun to be back @MRC_LMB for a visit to @PhilHolliger and PNAC. Honored to give a talk in the Sanger Seminar Room!

Sunlit @MRC_LMB this morning.

We are excited to share new mechanistic insights into DNA replication fidelity! How does human DNA Polymerase Epsilon recognise and proofread errors made during synthesis? 🧬 Read @NatureSMB nature.com/articles/s4159…

We have submitted our second paper on the topic the RNA world in collaboration with @PhilHolliger based on experimental work by @EmilLK2 and @mcrae_ewan in the @AndersenBioLab. Preprint is available on bioRxiv! Here comes a short explanation of the background and content.🧵1/7:

@MRC_LMB under Northern Lights #NorthernLights #AuroraBorealis #Cambridge @CamPostdocs

Nice news story about our recent research into the mythical RNA world, where we have explored the structure of the (proposed) central player: the RNA replicase. Thanks to @EmilLK2, @mcrae_ewan, @PhilHolliger and coauthors for making the research possible. sciencenews.dk/en/rna-researc…