Pharm Rev (ASPET)

Carnitine palmitoyltransferases regulate fatty acid oxidation and are emerging drug targets in obesity, diabetes, and cancer. Understanding isoform differences is key to developing safer, tissue-specific therapies. Read this #PharmRev publication: doi.org/10.1016/j.phar….

Researchers from @UCSF emphasize that applying Kirchhoff's Laws, a well-known physics methodology, provides a more comprehensive approach that can explain all high-quality clinical pharmacokinetic data and has clear advantages over traditional models: doi.org/10.1016/j.phar…

This insightful review by @Hmotulsky and his colleagues outlines best practices for handling lognormal data, enabling pharmacologists and biomedical researchers to draw stronger conclusions and communicate their results more effectively. Read here: doi.org/10.1016/j.phar….

Phosphodiesterases (PDEs) tightly regulate cAMP/cGMP in nanodomains that shape cell signaling, gene expression & epigenetics. PDE inhibitors show promise, but selectivity remains key to clinical success. Read the article here: doi.org/10.1016/j.phar…. #PharmRev

The safety of antidepressants during pregnancy is debated due to limited knowledge about their impact on fetal development & long-term outcomes. Researchers from @UofCalifornia focuses on perinatal pharmacotherapy for treating mood & anxiety disorders: doi.org/10.1016/j.phar….

Phosphodiesterases (PDEs) tightly regulate cAMP/cGMP in nanodomains that shape cell signaling, gene expression & epigenetics. PDE inhibitors show promise, but selectivity remains key to clinical success. Read more: doi.org/10.1016/j.phar….

An old dog with many new tricks! Check out to learn recent preclinical and clinical evidence that underscores the potential of Cytochrome P450 (CYP) 1B1 as a therapeutic target: doi.org/10.1016/j.phar….

Pericytes are emerging as key players in Alzheimer’s disease, regulating blood-brain barrier integrity, blood flow, and amyloid clearance. Check out this exciting new PharmRev publication highlighting this promising therapeutic target: doi.org/10.1016/j.phar…

Molecules targeting misfolded proteins through autophagy in #neurodegenerative diseases show promise for treatment! #PharmRev #Alzheimers #Parkinsons #ALS Read the article here: doi.org/10.1016/j.phar…

Gastroparesis is a gastric motility disorder characterized by delayed gastric emptying without mechanical obstruction. Learn about the options available in the pharmacological management of gastroparesis, as well as the unmet needs and challenges. 🔗 doi.org/10.1016/j.phar….

Check out this fascinating new #PharmRev publication that discusses the evolution of anticoagulants, from discoveries like heparin and vitamin K antagonists to today’s direct oral anticoagulants that have transformed patient care: Read here: doi.org/10.1016/j.phar….

Alan Prem Kumar, Ph.D. and team analyzed disruptions in cell cycle control and checkpoint mechanisms in cancer cells, evaluating novel therapeutic targets and strategies for #cancer treatment. Read the article here: doi.org/10.1016/j.phar…. #PharmRev #CellCyle

Antibiotic resistance is rising fast. Antibiotic hybrids and other polypharmacological approaches offer new hope by boosting efficacy and limiting resistance, particularly in biofilm-related infections. Read more about this #PharmRev publication here: doi.org/10.1016/j.phar….

Male infertility has various causes and choosing the right treatment is essential for success. This article categorizes existing pharmacological treatments according to underlying causes of infertility and highlights promising future therapeutics: doi.org/10.1124/pharmr….

Vitamin D signaling plays a critical role in both the innate and adaptive immune systems. Check out this exciting new #PharmRev publication highlighting the role of immunoregulation of vitamin D and its analogues! 🔗 Learn more about this here: doi.org/10.1016/j.phar….

Metabolic dysfunctione-associated steatotic liver disease is still on the rise. Check out this review by researchers from @CUHKofficial to understand the disease mechanism, review current treatment options, & explore future treatment strategies: doi.org/10.1016/j.phar…. #PharmRev

New research published in #PharmRev discusses the role of biomolecular condensation in regulating the Hippo signaling pathway. This pathway is a key player in tissue regrowth and homeostasis. Read the research here: doi.org/10.1016/j.phar….

Organic anion transporting polypeptides (OATPs) are membrane transport proteins that facilitate the cellular uptake of various substances. 🔗 Dive deep into the basic biology, pharmacology and toxicology of OATPs: doi.org/10.1016/j.phar…. #PharmRev @KUMC_GME

This fascinating new review discusses translational human studies and explores emerging areas such as sex differences, the role of sleep, and how craving mechanisms differ across drug classes and abstinence conditions. Read here: doi.org/10.1016/j.phar…. #PharmRev

This fascinating new publication discusses the shared cellular and molecular mechanisms between cancer and cardiovascular disease and the implications of specific therapies for drug repurposing: doi.org/10.1016/j.phar…. #PharmRev