Pancreatic Cell News

@PancreaticCell

An online resource for researchers studying pancreatic cells, pancreatic cancer, and diabetes. Part of the @STEMCELLTech Science News service.

Joined June 2010

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Pancreatic Cell News@PancreaticCell · Jul 14

Dr. David Hodson (@daveyboyhod) and team show that GLP1R is enriched as nanodomains on beta cell membranes that contact alpha cells, in keeping with increased single-molecule transcript expression. 💡 Learn more: bit.ly/451mubz

PancreaticCell's tweet image. Dr. David Hodson (@daveyboyhod) and team show that GLP1R is enriched as nanodomains on beta cell membranes that contact alpha cells, in keeping with increased single-molecule transcript expression.

💡 Learn more: bit.ly/451mubz

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Pancreatic Cell News@PancreaticCell · 3 h

Scientists show that STING is significantly elevated in T2DM β cells. They also clarify the key role of uncoupling protein 2, and reveal that interleukin-1β drives β cells to produce autoinflammation through the UCP2/mtDNA/STING axis in T2DM. 🔓 go.nature.com/45hV4OO

PancreaticCell's tweet image. Scientists show that STING is significantly elevated in T2DM β cells.

They also clarify the key role of uncoupling protein 2, and reveal that interleukin-1β drives β cells to produce autoinflammation through the UCP2/mtDNA/STING axis in T2DM.

🔓 go.nature.com/45hV4OO

Pancreatic Cell News@PancreaticCell · Jul 24

In this @cddpress study, researchers characterize PANoptosis as a novel form of cell death associated with mitotic catastrophe, and confirm the synergistic antitumor activity of RP-6306 and gemcitabine in #PDAC. 👉 go.nature.com/45hLvPT

PancreaticCell's tweet image. In this @cddpress study, researchers characterize PANoptosis as a novel form of cell death associated with mitotic catastrophe, and confirm the synergistic antitumor activity of RP-6306 and gemcitabine in #PDAC.

👉 go.nature.com/45hLvPT

Pancreatic Cell News@PancreaticCell · Jul 23

Check out new data from @T1D_TrialNet by Dr. @EmKSims and team! 😀 Congratulations to all the authors! 👏

EEmily K. Sims@EmKSims · Jul 23

Super excited this paper on islet autoantibody positive adults is finally online- we analyzed screening and #T1D progression in 100K adult relatives screened as part of @T1D_TrialNet . Available at: bit.ly/4md4scn

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Pancreatic Cell News@PancreaticCell · Jul 23

A research group led by Dr. Channing Der from @UNC provides rationale for combined inhibition of PRMT5 and KRAS in MTAP-deleted/KRAS-mutant #PDAC in their recent release in @CR_AACR. 🔗 Abstract link: bit.ly/44HLip1

PancreaticCell's tweet image. A research group led by Dr. Channing Der from @UNC provides rationale for combined inhibition of PRMT5 and KRAS in MTAP-deleted/KRAS-mutant #PDAC in their recent release in @CR_AACR.

🔗 Abstract link: bit.ly/44HLip1

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Pancreatic Cell News@PancreaticCell · Jul 22

Learn how to dissociate PSC-derived #epithelial cultures grown in 2D/3D formats into single cells with this collection of optimized protocols from @STEMCELLTech. 📃 bit.ly/4kxjvwC

PancreaticCell's tweet image. Learn how to dissociate PSC-derived #epithelial cultures grown in 2D/3D formats into single cells with this collection of optimized protocols from @STEMCELLTech. 📃

bit.ly/4kxjvwC

Pancreatic Cell News@PancreaticCell · Jul 22

Dr. Scott Soleimanpour and colleagues report that LONP1 promotes β cell survival and prevents #hyperglycemia by facilitating mitochondrial protein folding. 📂 📖 Full story: go.nature.com/4f246Tw

PancreaticCell's tweet image. Dr. Scott Soleimanpour and colleagues report that LONP1 promotes β cell survival and prevents #hyperglycemia by facilitating mitochondrial protein folding. 📂

📖 Full story: go.nature.com/4f246Tw

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Pancreatic Cell News@PancreaticCell · Jul 18

Dr. Lonnie Shea and team found that exendin-4 delivered alongside hPSC-derived β cell transplantation decreased time to improved blood glucose levels and enhanced β cell number, differentiation, and maturation. 〽️ bit.ly/44zYiNs

PancreaticCell's tweet image. Dr. Lonnie Shea and team found that exendin-4 delivered alongside hPSC-derived β cell transplantation decreased time to improved blood glucose levels and enhanced β cell number, differentiation, and maturation. 〽️

bit.ly/44zYiNs

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Pancreatic Cell News@PancreaticCell · Jul 17

Brian Pedro & @lauradelongwood outline the different histologic phenotypes, clinical characteristics, and neoplastic cell–intrinsic and –extrinsic drivers of pancreatic intraepithelial neoplasia and intraductal papillary mucinous neoplasm. @jclinicalinvest |…

PancreaticCell's tweet image. Brian Pedro &amp; @lauradelongwood outline the different histologic phenotypes, clinical characteristics, and neoplastic cell–intrinsic and –extrinsic drivers of pancreatic intraepithelial neoplasia and intraductal papillary mucinous neoplasm.

@jclinicalinvest |…

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Pancreatic Cell News@PancreaticCell · Jul 16

📢 Check out this new review to know how tumor-stroma crosstalk mechanisms shape metastatic progression in #PDAC! @jclinicalinvest | bit.ly/44SLr83

PancreaticCell's tweet image. 📢 Check out this new review to know how tumor-stroma crosstalk mechanisms shape metastatic progression in #PDAC!

@jclinicalinvest | bit.ly/44SLr83

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Pancreatic Cell News@PancreaticCell · Jul 15

Tick tock ⏰ Explore clock genes in pancreatic disease progression in this new review. 👇 bit.ly/44yGjXM

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Pancreatic Cell News@PancreaticCell · Jul 11

Dr. @BulentOzpolat4's lab at @MDAndersonNews found that eEF2K is associated with shorter patient survival and that eEF2K signaling is critical for #PDAC tumor growth. 🐭 Inhibition of eEF2K successfully suppressed tumor growth in two PDAC mouse models: go.nature.com/4lKudQT

PancreaticCell's tweet image. Dr. @BulentOzpolat4's lab at @MDAndersonNews found that eEF2K is associated with shorter patient survival and that eEF2K signaling is critical for #PDAC tumor growth.

🐭 Inhibition of eEF2K successfully suppressed tumor growth in two PDAC mouse models: go.nature.com/4lKudQT

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Pancreatic Cell News@PancreaticCell · Jul 10

📣 New target for trametinib-resistant #PDAC identified by Dr. Dongxin Lin & collaborators at Sun Yat-sen University! Check out @Gut_BMJ for the mechanism behind trametinib resistance and learn more about MAX dimerisation protein 1 as a druggable target: bit.ly/44nFOj3

PancreaticCell's tweet image. 📣 New target for trametinib-resistant #PDAC identified by Dr. Dongxin Lin &amp; collaborators at Sun Yat-sen University!

Check out @Gut_BMJ for the mechanism behind trametinib resistance and learn more about MAX dimerisation protein 1 as a druggable target: bit.ly/44nFOj3

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Pancreatic Cell News@PancreaticCell · Jul 9

#PDAC ranks among the most aggressive cancers with missense p53 GOF mutations in the TP53 gene being associated with worse clinical outcomes. 🧪 Dr. @ShivKSingh6 and his lab at @yourUMG have untangled misp53 mutants' therapeutic vulnerabilities: bit.ly/462RadG

PancreaticCell's tweet image. #PDAC ranks among the most aggressive cancers with missense p53 GOF mutations in the TP53 gene being associated with worse clinical outcomes.

🧪 Dr. @ShivKSingh6 and his lab at @yourUMG have untangled misp53 mutants' therapeutic vulnerabilities: bit.ly/462RadG

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Pancreatic Cell News@PancreaticCell · Jul 8

Dr. Esak Lee (@IsaacLeeLab) and his team at @Cornell have identified ALK7 inhibition as a promising strategy to target early metastatic dissemination in #PDAC. Read the paper in Molecular Cancer: bit.ly/402v86X

PancreaticCell's tweet image. Dr. Esak Lee (@IsaacLeeLab) and his team at @Cornell have identified ALK7 inhibition as a promising strategy to target early metastatic dissemination in #PDAC.

Read the paper in Molecular Cancer: bit.ly/402v86X

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Pancreatic Cell News@PancreaticCell · Jul 4

.@VUmedicine scientists report that pancreatic islet β-cell subtypes are derived from biochemically-distinct and nutritionally-regulated #islet progenitors. 🧫 🕳️ Dig into the details: go.nature.com/4eSbEZ3

PancreaticCell's tweet image. .@VUmedicine scientists report that pancreatic islet β-cell subtypes are derived from biochemically-distinct and nutritionally-regulated #islet progenitors. 🧫

🕳️ Dig into the details: go.nature.com/4eSbEZ3

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Pancreatic Cell News@PancreaticCell · Jul 3

In this @CellReports study, scientists showed that increased expression of cingulin (CGN) promoted pancreatic acinar-to-ductal metaplasia and CGN is progressively upregulated during #PDAC initiation and progression. 👉 bit.ly/44LKCPh

PancreaticCell's tweet image. In this @CellReports study, scientists showed that increased expression of cingulin (CGN) promoted pancreatic acinar-to-ductal metaplasia and CGN is progressively upregulated during #PDAC initiation and progression.

👉 bit.ly/44LKCPh

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Pancreatic Cell News@PancreaticCell · Jul 2

A sweet connection with a not-so-sweet effect. 🍬 Collaborators examine the complex pathophysiology of #PancreaticCancer-induced #hyperglycemia, focusing on impaired insulin sensitivity, β cell dysfunction, and more. bit.ly/44bBwv5

PancreaticCell's tweet image. A sweet connection with a not-so-sweet effect. 🍬

Collaborators examine the complex pathophysiology of #PancreaticCancer-induced #hyperglycemia, focusing on impaired insulin sensitivity, β cell dysfunction, and more.

bit.ly/44bBwv5

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Pancreatic Cell News@PancreaticCell · Jul 1

Congratulations to Dr. Michael Karin and team on their new @NatureCancer study! 👏 They found that a self-amplifying NRF2–EZH2 epigenetic loop converts KRAS-initiated progenitors to invasive pancreatic cancer. ➰ go.nature.com/4ns7lHD

PancreaticCell's tweet image. Congratulations to Dr. Michael Karin and team on their new @NatureCancer study! 👏

They found that a self-amplifying NRF2–EZH2 epigenetic loop converts KRAS-initiated progenitors to invasive pancreatic cancer. ➰

go.nature.com/4ns7lHD

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Pancreatic Cell News@PancreaticCell · Jul 1

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