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PRS papers

@PRS_pubmed

Polygenic Risk Score papers on PubMed

Joined February 2021

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PRS papers@PRS_pubmed · May 23, 2023

Whole-Exome Sequencing Reveals Distinct Genetic Profiles of Palindromic Rheumatism pubmed.ncbi.nlm.nih.gov/37219934/?utm_…

PRS_pubmed's tweet card. This study demonstrated the distinct genetic background between ACPA- and ACPA+ PR patients. Additionally, our findings strengthened that PR and RA were not genetically similar.

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PRS papers@PRS_pubmed · May 23, 2023

Coronary Artery Calcium Score and Polygenic Risk Score for the Prediction of Coronary Heart Disease Events pubmed.ncbi.nlm.nih.gov/37219552/?utm_…

PRS_pubmed's tweet card. In 2 cohorts of middle-aged to older adults from the US and the Netherlands, the coronary artery calcium score had better discrimination than the polygenic risk score for risk prediction of CHD. In...

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PRS papers@PRS_pubmed · May 23, 2023

Genetic testing in monogenic early-onset atrial fibrillation pubmed.ncbi.nlm.nih.gov/37217627/?utm_…

PRS_pubmed's tweet card. A substantial proportion of atrial fibrillation (AF) cases cannot be explained by acquired AF risk factors. Limited guidelines exist that support routine genetic testing. We aim to determine the...

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PRS papers@PRS_pubmed · May 23, 2023

Does maternal genetic liability to folate deficiency influence the risk of antiseizure medication-associated language impairment and autistic traits in children of women with epilepsy? pubmed.ncbi.nlm.nih.gov/37217097/?utm_…

PRS_pubmed's tweet card. In this cohort of pregnant women reporting widespread use of folic acid supplements, maternal genetic liability to folate deficiency did not significantly influence the ASM-associated risk of...

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PRS papers@PRS_pubmed · May 23, 2023

Polygenic risk affects the penetrance of monogenic kidney disease pubmed.ncbi.nlm.nih.gov/37214819/?utm_…

PRS_pubmed's tweet card. Variable penetrance of kidney disease in ADPKD and COL4-AN is partially explained by differences in polygenic risk profiles. Accounting for polygenic factors has the potential to improve risk...

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PRS papers@PRS_pubmed · May 22, 2023

Optimisation of polygenic risk scores in BRCA1/2 pathogenic variant heterozygotes in epithelial ovarian cancer pubmed.ncbi.nlm.nih.gov/37212253/?utm_…

PRS_pubmed's tweet card. The combination of PRS with age, family history, and hormonal factors significantly improved the EOC risk discrimination ability. However, the contribution of the PRS was small. Larger prospective...

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PRS papers@PRS_pubmed · May 22, 2023

Signatures of Neuropsychological Test Results in the Long Life Family Study: A Cluster Analysis pubmed.ncbi.nlm.nih.gov/37212095/?utm_…

PRS_pubmed's tweet card. The identified cognitive signatures capture multiple domains simultaneously and provide a holistic vision of cognitive function, showing that different patterns of cognitive function can coexist in...

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PRS papers@PRS_pubmed · May 21, 2023

Genome-wide Association Study of Bladder Cancer Reveals New Biological and Translational Insights pubmed.ncbi.nlm.nih.gov/37210288/?utm_…

PRS_pubmed's tweet card. We identified new genetic markers that provide biological insights into the genetic causes of bladder cancer. These genetic risk factors combined with lifestyle risk factors, such as smoking, may...

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PRS papers@PRS_pubmed · May 20, 2023

Genetic, environmental, and behavioral correlates of lifetime suicide attempt: Analysis of additive and interactive effects in two cohorts of US Army soldiers pubmed.ncbi.nlm.nih.gov/37208502/?utm_…

PRS_pubmed's tweet card. Recently developed measures of genetic liability to suicide attempt may convey unique information regarding an individual's risk of suicidal behavior. We calculated a polygenic risk score for suicide...

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PRS papers@PRS_pubmed · May 20, 2023

The relationship between cannabis use, schizophrenia, and bipolar disorder: a genetically informed study pubmed.ncbi.nlm.nih.gov/37208114/?utm_…

PRS_pubmed's tweet card. US National Institutes of Health, the Research Council Norway, the South-East Regional Health Authority, Stiftelsen Kristian Gerhard Jebsen, EEA-RO-NO-2018-0535, European Union's Horizon 2020...

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PRS papers@PRS_pubmed · May 20, 2023

Genetic architecture of plasma Alzheimer disease biomarkers pubmed.ncbi.nlm.nih.gov/37208024/?utm_…

PRS_pubmed's tweet card. Genome-wide association studies (GWAS) of cerebrospinal fluid (CSF) Alzheimer's Disease (AD) biomarker levels have identified novel genes implicated in disease risk, onset and progression. However,...

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PRS papers@PRS_pubmed · May 20, 2023

A complex systems model of breast cancer etiology: The Paradigm II Model pubmed.ncbi.nlm.nih.gov/37205649/?utm_…

PRS_pubmed's tweet card. The Paradigm II model illustrates the role of multiple etiologic factors in breast cancer from domains of biology, behavior and the environment. The value of the model is in providing a virtual...

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PRS papers@PRS_pubmed · May 20, 2023

Imputed Gene Expression versus Single Nucleotide Polymorphism in Predicting Gray Matter Phenotypes pubmed.ncbi.nlm.nih.gov/37205535/?utm_…

PRS_pubmed's tweet card. Genetics plays an important role in psychiatric disorders. A clinically relevant question is whether we can predict psychiatric traits from genetics, which holds promise for early detection and...

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PRS papers@PRS_pubmed · May 20, 2023

Evaluation of the Performance of the RECODe Equation with the Addition of Polygenic Risk Scores for Adverse Cardiovascular Outcomes in Individuals with Type II Diabetes pubmed.ncbi.nlm.nih.gov/37205500/?utm_…

PRS_pubmed's tweet card. In the present study, we demonstrate that although PRS associate with CVD outcomes independent of traditional risk factors among individuals with T2D, the addition of PRS to contemporary clinical...

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PRS papers@PRS_pubmed · May 19, 2023

Examining associations between genetic and neural risk for externalizing behaviors in adolescence and early adulthood pubmed.ncbi.nlm.nih.gov/37203444/?utm_…

PRS_pubmed's tweet card. Both the EXT PGS and P3 amplitude were significantly associated with externalizing behaviors among EA young adults. However, these associations with externalizing behaviors appear to be independent...

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PRS papers@PRS_pubmed · May 19, 2023

Individualised prescription of medications for treatment of obesity in adults pubmed.ncbi.nlm.nih.gov/37202547/?utm_…

PRS_pubmed's tweet card. Obesity continues to increase in prevalence globally, driven by changes in environmental factors which have accelerated the development of obesity in individuals with an underlying predisposition to...

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PRS papers@PRS_pubmed · May 19, 2023

Incidence of Interstitial Lung Abnormalities: The MESA Lung Study pubmed.ncbi.nlm.nih.gov/37202153/?utm_…

PRS_pubmed's tweet card. Incident ILA and fibrotic ILA were estimated by review of cardiac imaging studies. These findings may lead to wider application of a screening tool for atherosclerosis to identify pre-clinical lung...

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PRS papers@PRS_pubmed · May 19, 2023

Association of time spent in outdoor light and genetic susceptibility with the risk of type 2 diabetes pubmed.ncbi.nlm.nih.gov/37201819/?utm_…

PRS_pubmed's tweet card. To explore the joint association of time spent in outdoor light and genetic susceptibility with the risk of type 2 diabetes (T2D). A total of 395,809 individuals of European ancestry with diabetes-...

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PRS papers@PRS_pubmed · May 19, 2023

Family studies: a useful tool to better understand spondyloarthritis pubmed.ncbi.nlm.nih.gov/37201576/?utm_…

PRS_pubmed's tweet card. Spondyloarthritis (SpA) is an immune-mediated disease characterized by a high heritability, reflected by strong familial aggregation. Therefore, family studies are a powerful tool for elucidating the...

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PRS papers@PRS_pubmed · May 19, 2023

Integrating multiple traits for improving polygenic risk prediction in disease and pharmacogenomics GWAS pubmed.ncbi.nlm.nih.gov/37200155/?utm_…

PRS_pubmed's tweet card. Polygenic risk score (PRS) has been recently developed for predicting complex traits and drug responses. It remains unknown whether multi-trait PRS (mtPRS) methods, by integrating information from...

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