The Patient-Centered Outcomes Research Institute

Each year, 300K+ older adults in the United States fracture a hip that often requires surgery to repair. This new Evidence Update features a PCORI-funded CER study that is the largest randomized controlled trial to date comparing the effects of spinal versus general anesthesia…

Approximately 27% of Americans experience degenerative disease of the lumbar spine by age 65. PCORI is seeking public feedback on a draft report of a systematic review on the Performance of Fusion Procedures for Degenerative Disease of the Lumbar Spine. pcori.me/4lvwjVc

The latest issue of PCORI’s Emerging Health Care Innovation Brief features clinical trial results for diabetes therapies and a pilot program to accelerate FDA drug reviews. Topics to watch include: ◼️ Ateganosine ◼️ Tirabrutinib Explore emerging therapies:…

In a PCORI-funded patient-centered CER study, researchers compared 2 approaches to support the start and completion of Hepatitis C virus treatment for people who inject drugs: 1️⃣ Patient navigation, where trained individuals help patients navigate treatment 2️⃣ Directly observed…

PCORI seeks to support high-quality patient-centered CER studies focusing on rare diseases through the upcoming Addressing Rare Diseases Topical PFA! Learn more details of this funding announcement during PCORI's Applicant Town Hall on Aug. 19 at 12 pm ET.…

As you prepare your LOI submission for upcoming Engagement Award funding opportunities, register for a virtual office hour session. These online sessions are a valuable opportunity to: ◼️ Discuss the application process ◼️ Explore the programmatic fit of your proposed project…

Join PCORI on Aug. 18 for an information-rich webinar on the Cycle 3 2025 Broad Pragmatic Studies PCORI Funding Announcement! During this webinar, PCORI will walk you through details of this funding announcement, including both programmatic and administrative requirements,…

Register Now for #PCORI25! Join patients, caregivers and members of the broader healthcare community for this free, 2 day event focused on advancing patient-centered CER. See you in Washington, D.C. this October! Learn more & register: pcori.me/3TvVg6u

🚨Due Tomorrow: Seeking Your Input on the Medical Management of Kidney Stones🚨 PCORI is gathering public input on a draft report of a systematic review on medical management of recurrent kidney stone disease in adults and children. pcori.me/4llc8IO

A PCORI-funded patient-centered CER study compared two approaches to help youth with bipolar spectrum disorders who are on antipsychotics control their weight: 🍎 A healthy eating and exercise educational program alone 📖 An educational program plus metformin The results…

PCORI intends to release a funding announcement on Aug. 12 with the goal of funding research on Alzheimer’s disease and related dementias, maternal sleep health and treatments and strategies for menopausal symptoms. If you are interested in applying for PCORI funding, read the…

The majority of PCORI-funded CER study results incorporated into guidelines authored by U.S.-based organizations are cited substantively to support a specific recommendation for care. pcori.me/4l14G6D

Closing Next Week: Provide Public Comment on Medical Management of Kidney Stone Disease PCORI is seeking public feedback on a draft report of a systematic review on medical management of recurrent kidney stone disease in adults and children. pcori.me/4llc8IO

The latest edition of PCORI’s Emerging Health Care Innovation Brief offers insights from clinical trials discussed at #ASCO25 and regulatory news from the FDA. Topics to watch include: ✔️ AD109: an investigational oral medication designed to treat obstructive sleep apnea ✔️…

Registration Is Now Open for #PCORI25! This event in patient-centered CER unites patients, caregivers and individuals from the broader healthcare community for 2️⃣ inspiring days filled with innovation, learning and networking. 📆 Oct. 21-22 📍 Washington, DC 🔗…

Each year, 300K people in the U.S. are affected by appendicitis. The PCORI-funded CODA study, the largest of its kind, shows antibiotics are a viable alternative to surgery for treatment. These findings have been cited in clinical guidelines as evidence for this option.…

When people face health decisions, they deserve to know which treatments work best. PCORI funds CER that puts existing treatments side-by-side, creating evidence people can trust when making healthcare choices. 🔬Better evidence = better care pcori.me/4eoEYFL

Seeking Your Input on the Medical Management of Kidney Stones Whether you're a patient, clinician or member of the broader healthcare community, your perspective is valuable and can help strengthen this research to support better healthcare decisions in the future. Share your…

PCORI seeks to support high-quality patient-centered CER studies focusing on rare diseases through the upcoming Addressing Rare Diseases Topical PFA! If you are interested in applying, PCORI invites you to request a virtual office hour! pcori.me/4klIvaF

A PCORI-funded patient-centered CER study is comparing two approaches to help older adults and their clinicians have informed conversations about the benefits and harms of diabetes medicines. The goal is to find effective ways to safely reduce medication use when appropriate.…