Olaf Perdijk
@OPerdijk
Assistant Professor of Mucosal Immunology. Focussed on interplay of gut microbiome and host metabolism and immunity.
Read the latest #SMIMemberPaper from @BenJMarsland and colleagues in @ImmunityCP on how early life #Antiboitics reduce systemic indole-3-propionic acid levels required to maintain mitochondrial respiration in the lung. bit.ly/4dhAxuK
‘@cellhostmicrobe special issue illustrates how microbial composition of specific tissues and organs systemically contributes to maintenance of homeostasis (health) or drives disease development and progression. Take a look. hubs.li/Q02LpDj30
Antibiotic-driven dysbiosis in early life disrupts indole-3-propionic acid production and exacerbates allergic airway inflammation in adulthood dlvr.it/TByDzF
"Antibiotic-driven #dysbiosis in early life disrupts indole-3-propionic acid production and exacerbates allergic airway inflammation in adulthood," concludes a study in @ImmunityCP. @OPerdijk #microbiota👇 cell.com/immunity/abstr…
I am very grateful to @NatRevImmunol for highlighting our recent publication! Special thanks to Lucy Bird for doing a fantastic job in summarizing our findings in such detailed yet concise way. dlvr.it/TBDkcN
Early life antibiotics have lasting effects on the lung epithelium dlvr.it/TBDkcN
Systems immunology is not only immunology with more data. It is a new way of thinking about immune systems as integrated multiagent systems w particular value for making variable human immune system more interpretable: cell.com/trends/immunol…
📚 Just published a BCR repertoire sequencing protocol! This is the result of a great collaboration with Prasanti Kotagiri, Rachael Bashford-Rogers and @vanessabryantoz. Thanks to editor @KimLJacobson for the opportunity! link.springer.com/protocol/10.10…
Proteins, proteins, proteins. How 3,000 blood proteins can help predict 10-year risk of >200 common and rare diseases, beyond genomic markers nature.com/articles/s4159… @uk_biobank @NatureMedicine
Media coverage continues on research led by @BenJMarsland and @OPerdijk on #asthma and antibiotic use in infancy, centring on the molecule IPA. youtube.com/watch?v=XJoMGI…
Melbourne researchers have unlocked why children are more likely to develop asthma after early exposure to antibiotics. Professor Ben Marsland speaks to @mikeamor7 about the research. 7NEWS.com.au #7NEWS
🇦🇺 Asthma Breakthrough ▫It’s one of asthma’s biggest causes and can begin in babies, but doctors did not know why – and therefore how to prevent it – until now ▫@sarahbooth_14 #frontpagestoday #Australia @theheraldsun 🇦🇺
Viruses, OTT cleanliness, genetics … all these have been linked to a higher chance of having #asthma. Now, @Benjmarsland has led research isolated the molecule IPA: when subjected to antibiotic onslaught, IPA disappears from the airways, taking with it valuable protection…
Microbiome derived indole-3-propionic acid prevents long-lasting mitochondrial damage in airway epithelial cells & hyperresponsiveness to allergen challenge, reducing allergic inflammation in adulthood @ImmunityCP @BenJMarsland @TomaszWypych8 @OPerdijk cell.com/immunity/fullt…
Online now: Antibiotic-driven dysbiosis in early life disrupts indole-3-propionic acid production and exacerbates allergic airway inflammation in adulthood dlvr.it/T9csJ3
Excited to share my first senior author publication out now in @NatureComms! We characterised the γδ T cells in patients with CVID @WEHI_research @TheRMH nature.com/articles/s4146…
Ever wondered how microbes influence respiratory health? Check out our new review in @physiolrev with @rossana_azzoni and @BenJMarsland!journals.physiology.org/doi/abs/10.115… #microbiome #Immunology