Neural Regeneration Research-Journal

New study reveals how PINK1 and Parkin's unique distribution in primate brains contributes to Parkinson's! Researchers found PINK1 is selectively expressed in primate brains, and its loss causes neuron degeneration. journals.lww.com/nrronline/full… #ParkinsonsDisease #Neuroscience

The review explores the latest #Biomarkers, including anti-AChR and anti-MuSK antibodies, and their pivotal roles in diagnosis and treatment in #MyastheniaGravis. Discover how emerging biomarkers like microRNAs are paving the way for personalized medicine. sciencedirect.com/science/articl…

The new research reveals how Nutlin-3a and exercise can combat glioma! By targeting MDM2 and influencing the p53 pathway, this duo shows promise in reducing tumor growth and improving neurological function in mice. journals.lww.com/nrronline/full… #Cancer #NeuroOncology #ExerciseMatters

Dyslipidemia got you down? The study shows that magnesium hydride can enhance the lipid-lowering effects of atorvastatin in obese mice. By suppressing CYP3A expression, MgH2 helps maintain statin levels in the body. journals.lww.com/mgar/fulltext/… #MedicalGasResearch #LipidManagement

A narrative review outlines how different isolation modalities of #meniscus fibrochondrocytes generate molecularly and functionally distinct cell populations, which can be leveraged for meniscus #tissueengineering and #repair. #bioengineering journals.lww.com/rmr/fulltext/2…

Cell therapy for neurological damage after #cardiacarrestis advancing. The study shows hypoxia-preconditioned BMSCs significantly reduce neuronal pyroptosis via the MAPK/NF-κB pathways and mitochondrial ROS suppression. journals.lww.com/nrronline/full… #neuroprotection #stemcelltherapy

Unraveling the complex world of #MyastheniaGravis #Biomarkers! This review highlights key diagnostic tools like anti-acetylcholine receptor antibodies & repetitive nerve stimulation tests. #Neuroscience sciencedirect.com/science/articl…

New research reveals a potential link between maternal allergic asthma and increased #autismspectrumdisorder risk in offspring! This may alter fetal #Neurodevelopment, and immune dysregulation & microglia changes could be key factors. journals.lww.com/nrronline/full…

#Astrocytes in the ventrolateral preoptic nucleus are vital for #sleep homeostasis, sensing extracellular glucose levels and releasing adenosine to drive sleep, by inhibiting wake-promoting neurons and activating sleep-promoting ones. journals.lww.com/nrronline/full…

Discover how robot-assisted minimally invasive techniques are transforming peripheral nerve microsurgery! This review highlights the precision, safety, and aesthetic advantages of these advanced methods. journals.lww.com/atn/fulltext/2… #RobotAssistedSurgery #PeripheralNerve

Neurodegenerative diseases and metabolic disorders like diabetes are linked by oxidative stress. AI and machine learning are revolutionizing our understanding of these conditions by analyzing complex pathways. journals.lww.com/mgar/fulltext/… #HealthTech #AInomics #MedGasRes

Learn about the #DrugDesign and redesign journey for #TransthyretinAmyloidosis! Researchers develop new transthyretin kinetic stabilizers, from tolcapone to M-23 and PITB. Molecular dynamics simulations guided the creation of potent transthyretin binders. journals.lww.com/nrronline/full…

#HER096, a brain - penetrating neurotrophic factor mimetic derived from CDNF, shows promise. It can be administered subcutaneously, cross the blood - brain barrier, and may modify disease progression. journals.lww.com/nrronline/full…

Ferroptosis, an iron-driven cell death mode, plays a crucial role in osteogenic differentiation. Understanding its link with bone cells could revolutionize bone defect healing. journals.lww.com/rmr/fulltext/2… #BoneRegeneration #Orthopedics #RegenerativeMedicine

Anti-amyloid antibodies like aducanumab & lecanemab show promise in clearing amyloid plaques, yet debate persists on their clinical impact. Meta-analysis highlights their effects, risks, and the role of APOE-ε4. journals.lww.com/nrronline/full… #Alzheimers #Neuroscience #AβTherapy

Mitochondrial epigenetics is revolutionizing our understanding of aging! From mtDNA methylation to non-coding RNA roles, new insights reveal how mitochondrial-nuclear crosstalk drives age-related diseases. journals.lww.com/aa/fulltext/20… #AgingResearch #Epigenetics #Mitochondria

Say goodbye to harsh chemo side effects! Engineered Metal–organic frameworks are disrupting cancer cells by messing with their iron balance, triggering ferroptosis. It's like giving cancer cells a taste of their own medicine. journals.lww.com/mgar/fulltext/… #cancercure #MOFmagic

💡Discover the role of #TSPO in #neurodegeneration! This protein impacts mitochondrial health and neurosteroidogenesis, showing promise in #AlzheimersResearch . TSPO ligands may reduce cognitive deficits and amyloid-beta levels. journals.lww.com/nrronline/full…

The #DISCO database is revolutionizing #SingleCellRNASeq! With over 100 million cells and 461 cell types, it’s a game-changer for analyzing cellular heterogeneity. Its user-friendly tools and standardized data make complex analyses accessible. journals.lww.com/atn/fulltext/2…

Peripheral amyloid-β aggregates may act as “seeds,” potentially inducing brain amyloidosis. This mini-review explores the prion-like features of Aβ and its implications in Alzheimer’s disease pathology. journals.lww.com/nrronline/full… #AlzheimersDisease #AmyloidBeta #Neurodegeneration