Adam Mulkern
@MulkernAdam
Postdoc, MacLean lab, high-throughput experimental evolution, AMR 🧬 @UniofOxford
Excited to share something from my previous postdoc with @mgalactus, a collaboration with the @JoergLab using lab evolution to see how different bacterial species develop resistance to programmable antibiotics: biorxiv.org/content/10.110…
Excited to share our study led by @SakenovaNazgul! We used chemical genetics to identify and understand cross-resistance & collateral-sensitivity (CS) between antibiotics and reduced AMR development with CS drug pairs @embl with @camille_goemans @EPFL_en nature.com/articles/s4156…
What a month...I spent June in the US at the @CSHL Advanced Bacterial Genetics course and then the @GordonConf Molecular Mechanisms in Evolution! I met so many cool people along the way — special shoutout to my course lab partner, Max!
Hopped over to Northern Ireland last week to give a talk at @QUBelfast for their AMR seminar series. Thanks very much to @WheatleyRM, @LindaOyama, and @sharonhuws for hosting me!
Wrapped up 2024 with the @TypasLab in Heidelberg @embl, doing some evolution experiments with @StefanBassler. Had an incredible time and looking forward to an exciting year of science in 2025!
Stress-testing #asobiotics…🦠 @MulkernAdam & @mgalactus from TWINCORE, in collaboration with #HIRI’s @JoergLab, have employed in-vitro laboratory evolution to study how different bacteria develop resistance to programmable antibiotics. Check out their preprint to learn more. 👇
We used in-vitro laboratory evolution to "stress test" the next generation class of antibiotics based on antisense oligos ("asobiotics"). Head over to our new preprint to find out more! (links in the next tweets)
Big shoutout to these 3 from the MacLean Lab, currently in SF, who just launched Evolvere BioSciences on @ycombinator! 'Making next-generation antibiotics that outsmart bacterial evolution' Take a look and drop them an upvote! ycombinator.com/launches/Lct-e…
Published today in @EvolLetters 🎉🎉 Antibiotic resistance alters the ability of Pseudomonas aeruginosa to invade bacteria from the respiratory microbiome academic.oup.com/evlett/article… A short thread 🧵:
Had a fun day visiting @AdamWinnifrith at @TheCrick and got to check out their epic lab setup!
Thanks to @WheatleyRM for organising an excellent AMR & Microbiome workshop @magdalenoxford
After an amazing few years in Germany, I'll soon be starting a postdoc in the MacLean lab @UniofOxford 🧬 Thanks to @mgalactus for the mentorship and I'm very excited for what's ahead!
The esteemed FEMS Summer School for Postdocs returns, inviting promising postdoctoral researchers in microbiology to partake in a transformative experience. It provides unparalleled opportunities for personal and professional growth. #FSSfP Apply Now: fems-microbiology.org/about_fems/net…
Our manuscript describing our tool panfeed has now been published in Microbial Genomics (@MicrobioSoc): microbiologyresearch.org/content/journa… Head over to our lab website for a quick explainer: microbial-pangenomes-lab.org/2023/11/09/Mul…
Here's a new preprint from the lab presenting panfeed, a tool to improve interpretability of k-mer based microbial GWAS, led by @HanNeb1337 biorxiv.org/content/10.110…
Grateful for the opportunity to share my work @microbesNG popup 🙏🏻
🎥Here's @MulkernAdam's fab flash presentation 'The impact of E.coli genetic background on antimicrobial resistance evolution' showing collateral #AMR resistance 😬😨 youtu.be/HyBtM-kWiKk @mgalactus @TWINCOREtweets @MHH_life @helmholtz_HZI #MNGPopUp #ECR #MicrobialGenomics
What a week it's been...very sad to say bye to this group 🥲 @FEMSmicro
Squeezing in some final experiments before the @FEMSmicro postdoc school in Split. Excited to meet everyone 🇭🇷
Pleasure to give a short talk for the #MNGPopUp today at Manchester Uni, met lots of cool people too!
Very grateful to present my poster at #EESMicrobiology 🧫 The discussions were very engaging and insightful but my eagerness to return to the lab has reached a whole new level!
After months of waiting, my 384-well plates have arrived at last! Now I'm moving my bed into the lab until these experiments are finished...
