Molecular Therapy

@MolTherapy

The leading family of journals in gene & cell therapy. Journals include Molecular Therapy, Methods & Clinical Developments, Nucleic Acids, and Oncology.

Joined February 2014

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Molecular Therapy@MolTherapy · Jul 23

Amlodipine as an Immunomodulatory Agent in Cancer Therapy: Enhancing Dendritic Cell Activation in Combination with Tumor-associated Antigen dlvr.it/TM3v9d #genetherapy #celltherapy

MolTherapy's tweet card. Amlodipine acts as an immunomodulatory agent by enhancing dendritic cell activation and augmenting antitumor immune responses in the presence of tumor-associated antigens, offering a promising...

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Molecular Therapy@MolTherapy · 13 h

Targeting glioblastoma using oncolytic virus-based therapeutic candidates dlvr.it/TM730Q

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Molecular Therapy@MolTherapy · Jul 25

Development of VNX-101, an Adeno-Associated Virus with Less Immunogenicity and Efficient Long-Term Expression of a CD19 T-Cell Engager dlvr.it/TM62fG #MTMCD

MolTherapy's tweet image. Development of VNX-101, an Adeno-Associated Virus with Less Immunogenicity and Efficient Long-Term Expression of a CD19 T-Cell Engager dlvr.it/TM62fG #MTMCD

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Molecular Therapy@MolTherapy · Jul 25

NOTCH2 mutation in centronuclear myopathy: Beyond the scope dlvr.it/TM5x5R #genetherapy #celltherapy

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Molecular Therapy@MolTherapy · Jul 24

Selective inhibition of ERO1α with M6766, a novel small-molecule inhibitor, prevents arterial thrombosis and ischemic stroke in mice dlvr.it/TM4zhN #genetherapy #celltherapy

MolTherapy's tweet card. Endoplasmic reticulum oxidoreductase 1α (ERO1α) plays a crucial role in platelet activation and aggregation under thrombotic conditions. Using a high-throughput screen, Cho and colleagues identify...

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Molecular Therapy@MolTherapy · Jul 24

Pharmacological Gq targeting prevents asthmatic airway remodeling dlvr.it/TM4zbg #genetherapy #celltherapy

MolTherapy's tweet card. Pharmacological inhibition of Gq proteins attenuates airway remodeling in asthma in both in vivo and in vitro models. This is highly relevant becasue there are currently no approved drugs that...

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Molecular Therapy@MolTherapy · Jul 24

Targeted Silencing of Engrailed-1 Reprograms Profibrotic Fibroblast Lineages for Scarless Wound Healing dlvr.it/TM4zWD #genetherapy #celltherapy

MolTherapy's tweet card. Fibroblast-mimic carrier (FibroMC) can effectively silence En1 expression in Engrailed-1 (En1) lineage-positive fibroblasts (EPFs), reversing the profibrotic effects of EPFs. A single topical...

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Molecular Therapy@MolTherapy · Jul 24

Cell-Selective Telomere Damage by Thiopurine-Based Oligonucleotide for Diffuse Large B-cell Lymphoma Immunotherapy dlvr.it/TM4zPQ #genetherapy #celltherapy

MolTherapy's tweet card. To overcome challenges in targeting cancers with active telomerase while reducing on-target/off-tumor toxicities, Kortylewski and colleagues developed cell-selective oligodeoxynucleotides to deliver...

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Molecular Therapy@MolTherapy · Jul 24

Designing better gene therapies for lysosomal storage disorders using engineered enzymes dlvr.it/TM4sm5 #genetherapy #celltherapy

MolTherapy's tweet card. Despite rapid progress over recent years, relatively few gene therapies have been fully translated into clinical use, as fundamental challenges persist in delivering sufficient doses for clinical...

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Molecular Therapy@MolTherapy · Jul 23

#MolecularTherapy Oncology has an active call for papers for a special issue on Advancements in Pediatric Cancer Therapy. Learn more and submit your paper before September 30, 2025: dlvr.it/TM4ZW5

MolTherapy's tweet image. #MolecularTherapy Oncology has an active call for papers for a special issue on Advancements in Pediatric Cancer Therapy. Learn more and submit your paper before September 30, 2025:
dlvr.it/TM4ZW5

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Molecular Therapy@MolTherapy · Jul 23

Exploring Adenosine Analogs for Chondrosarcoma Therapy: In Vitro and In Vivo Insights dlvr.it/TM3vSk #MTNA

MolTherapy's tweet card. Chondrosarcomas are resistant to conventional therapies. This study identifies the adenosine analogs Cladribine and Clofarabine as potent inducers of apoptosis and cell cycle arrest in preclinical...

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Molecular Therapy@MolTherapy · Jul 23

MVA-HBVac – a novel vaccine vector that allows pan-genotypic targeting of hepatitis B virus by therapeutic vaccination dlvr.it/TM3vLc #MTNA

MolTherapy's tweet card. Ulrike Protzer and colleagues developed a novel therapeutic hepatitis B vaccine vector, MVA-HBVac, designed to target 95% of circulating HBV isolates worldwide. Administration of MVA-HBVac following...

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Molecular Therapy@MolTherapy · Jul 23

Oncolytic HSV and cancer drug interactions: Current clinical status and future directions dlvr.it/TM3vGn #genetherapy #celltherapy

MolTherapy's tweet card. Kaur and colleagues provide a timely overview of the current stage of HSV-based oncolytic virotherapies in clinical trials. Analysis of clinical data of first-generation oncolytic HSVs tested in...

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Molecular Therapy@MolTherapy · Jul 23

Are viral vector-mediated therapies compatible with aberrant glycosylation? dlvr.it/TM3v7r #MTMCD

MolTherapy's tweet card. Muffels and colleagues demonstrate here that altered glycosylation, which is observed in congenital-, liver- and neurodegenerative disorders, can reduce AAV-binding glycan expression, potentially...

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Molecular Therapy@MolTherapy · Jul 22

Controlling CRISPR-Cas9 genome editing in human cells using a molecular glue degrader dlvr.it/TM2rWR #MTNA

MolTherapy's tweet card. Khajanchi and Saha present a small-molecule-controlled Cas9-degron (Cas9-d) system for reversible regulation of CRISPR genome editing in human cells. Used as an experimental in vitro tool, Cas9-d...

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Molecular Therapy@MolTherapy · Jul 22

CDCP1-Targeting ADC Outperforms Standard Therapies in Ras-Mutant Pancreatic Cancer dlvr.it/TM2rS7

MolTherapy's tweet card. Park and colleagues report that a CDCP1-targeting antibody–drug conjugate achieves durable tumor remission in Ras-mutant pancreatic cancer models, surpassing current therapies. This work highlights...

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Molecular Therapy@MolTherapy · Jul 22

Ovatodiolide Triggers Ferroptosis in High-Grade Serous Ovarian Cancer Through HMOX1 Upregulation dlvr.it/TM2rN6

MolTherapy's tweet card. Ovatodiolide, a bioactive macrocyclic diterpenoid derived from the traditional medicinal herb Anisomeles indica, induces potent cytotoxicity in high-grade serous ovarian carcinoma (HGSC) cells by...

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Molecular Therapy@MolTherapy · Jul 22

Oncolytic Vaccinia Virus Expressing Non-Secreted Decoy-Resistant IL-18 Mutein Elicits Potent Antitumor Effects with Enhanced Safety dlvr.it/TM2rJ6

MolTherapy's tweet card. An oncolytic vaccinia virus delivering a non-secreted IL-18 mutein (nsmDR-18) enhances antitumor immunity by activating CD8+ T cells and reshaping the tumor microenvironment. Combination with...

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Molecular Therapy@MolTherapy · Jul 22

Rapid Cochlear Gene Therapy in Adult Deaf Mice: Vglut3 Rescue via AAV8 Achieves Day-1 Hearing Restoration dlvr.it/TM2rDh #MTMCD

MolTherapy's tweet card. Gene therapy rapidly restores hearing in deaf mice, with functional recovery beginning within 24 hours—far sooner than previously thought. By mapping transgene expression and auditory repair in real...

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Molecular Therapy@MolTherapy · Jul 22

Considerations in Biodistribution Evaluation of iPSC-derived Cell Therapy: A Pancreatic Islet Cell Case Study dlvr.it/TM2r70 #MTMCD

MolTherapy's tweet card. A droplet digital PCR method was optimized, and its quantitativity was validated to evaluate the biodistribution characteristics of induced pluripotent stem cell-derived pancreatic islet cells. The...

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