Modern Pathology
@ModernPathology
Official Journal of @TheUSCAP, focused on clinical and translational research in #pathology of #humandisease. Sibling Journal: @LIjournal.
We would wonder where this hepatocellular carcinoma with large nuclei would lie in the model reported this month: Patil A, Hasan B, Park BU, Smith L, Sivasubramaniam P, Elhalaby R, Elessawy N, Nazli S, DaCosta A, Shabaan A, Cannon A, Lau C, Hartley CP, Graham RP, Moreira RK. A…
H3K27me3 loss is good but not perfect for confirming a diagnosis of malignant peripheral nerve sheath tumor; this one arose in a diffuse neurofibroma. 1: Schaefer IM, Fletcher CD, Hornick JL. Loss of H3K27 trimethylation distinguishes malignant peripheral nerve sheath tumors from…
Back to some basics. Leiomyosarcomas are amongst the sarcoma types that spread to lymph nodes, a phenomenon that is interesting to see.
The more T cells in EBV-related gastric carcinoma, the merrier for the patient. This one has both squamous and glandular differentiation. Soeratram TTD, Biesma HD, Egthuijsen JMP, Meershoek-Klein Kranenbarg E, Hartgrink HH, van de Velde CJH, Mookhoek A, van Dijk E, Kim Y, Ylstra…
Synovial sarcoma can pop up anywhere - including the GI tract. This example is perfectly biphasic and has calcification at no extra charge. Ortiz Requena D, Longacre TA, Rosenberg AE, Velez Torres JM, Yanchenko N, Garcia-Buitrago MT, Voltaggio L, Montgomery EA. Synovial Sarcoma…
Hu S, Alpert L, Cates JMM, Gonzalez RS; Rare GIST Risk Stratification Group. Gastrointestinal stromal tumors (GISTs) arising in uncommon locations: clinicopathologic features and risk assessment of esophageal, colonic, and appendiceal GISTs. Mod Pathol. 2022 Apr;35(4):554-563.…
Once in a while gastrointestinal stromal tumors (GISTs) spread to bone! Learn about GISTs in less common primary sites: Gastrointestinal stromal tumors (GISTs) arising in uncommon locations: clinicopathologic features and risk assessment of esophageal, colonic, and appendiceal…
Once in a while gastrointestinal stromal tumors (GISTs) spread to bone! Learn about GISTs in less common primary sites: Gastrointestinal stromal tumors (GISTs) arising in uncommon locations: clinicopathologic features and risk assessment of esophageal, colonic, and appendiceal…
Carter CS, Patel RM. Cutaneous soft tissue tumors: diagnostically disorienting epithelioid tumors that are not epithelial, and other perplexing mesenchymal lesions. Mod Pathol. 2020 Jan;33(Suppl 1):66-82.PMID: 31685962.
This is a benign epithelioid peripheral nerve sheath tumor (schwannoma) of a digit. Modern Pathology offers some help in sorting out epithelioid skin lesions: Carter CS, Patel RM. Cutaneous soft tissue tumors: diagnostically disorienting epithelioid tumors that are not…
This is a benign epithelioid peripheral nerve sheath tumor (schwannoma) of a digit. Modern Pathology offers some help in sorting out epithelioid skin lesions: Carter CS, Patel RM. Cutaneous soft tissue tumors: diagnostically disorienting epithelioid tumors that are not…
Here is Editor-in-Chief @RhondaYantiss discussing one of the best articles in Modern Pathology last year. Submit your articles and share your research! #PathX
Needle biopsy of a gastric glomus tumor; in this location, a neuroendocrine (carcinoid) tumor would be considered. These lesions sport various molecular alterations, but immunohistochemistry can confirm the diagnosis. Iwamura R, et al. PDGFRB and NOTCH3 Mutations are Detectable…
Simbolo M, Silvestris N, Malleo G, Mafficini A, Maggino L, Cocomazzi A, Veghini L, Mombello A, Pezzini F, Sereni E, Martelli FM, Gkountakos A, Ciaparrone C, Piredda ML, Ingravallo G, Paolino G, Nappo F, Rapposelli IG, Frassinetti L, Saragoni L, Lonardi S, Pea A, Paiella S, Fassan…
SMAD4/DPC4 nuclear loss on immunohistochemistry can support an interpretation of pancreatic ductal adenocarcinoma even when there is signet ring cell morphology (this example is more typical). Simbolo M, et al. Clinical and Genomic Characterization of Pancreatic Ductal…
SMAD4/DPC4 nuclear loss on immunohistochemistry can support an interpretation of pancreatic ductal adenocarcinoma even when there is signet ring cell morphology (this example is more typical). Simbolo M, et al. Clinical and Genomic Characterization of Pancreatic Ductal…
Here is a unique opportunity to be an editor for a USCAP journal.
@LIjournal is seeking a Social Media Editor. Are you an MD or PhD with expertise in basic, translational, or anatomic pathology who has experience creating social media posts? Join our team! Visit uscap.org/smedia for details and SHARE to spread the word! #PathX
This is truly an excellent opportunity for a #PathTwitter regular!
Laboratory Investigation, a @theUSCAP pathology journal, seeks a Social Media Editor. Are you an MD or PhD with expertise in basic, translational, or anatomic pathology who has experience creating social media posts? Join our team! Visit uscap.org/smedia for details.
Despite new discoveries, we still need to remind our surgical colleagues that dermatofibrosarcoma protuberans tracks along connective tissue septa well past where the surgeon anticipates. Smith SC, Sweeney K, Evans MG, Angara K, Reynolds C, Price B, Park SJ, Elliott A, Oberley…
Filie AC, Lage JM, Azumi N. Immunoreactivity of S100 protein, alpha-1-antitrypsin, and CD68 in adult and congenital granular cell tumors. Mod Pathol. 1996 Sep;9(9):888-92. PMID: 8878020. #UMiamiPath @LizMontgomeryMD @science_press
There are so many wonderful vintage articles in Modern Pathology, including this classic on granular cell tumor. Note the pseudoepitheliomatous hyperplasia associated with this esophageal granular cell tumor. Filie AC, Lage JM, Azumi N. Immunoreactivity of S100 protein,…
There are so many wonderful vintage articles in Modern Pathology, including this classic on granular cell tumor. Note the pseudoepitheliomatous hyperplasia associated with this esophageal granular cell tumor. Filie AC, Lage JM, Azumi N. Immunoreactivity of S100 protein,…
Myxoinflammatory fibroblastic sarcoma was first described in Modern Pathology using different terminology. It's one of the many legacies of Dr. Sharon Weiss, a grande dame of pathology. Montgomery EA, Devaney KO, Giordano TJ, Weiss SW. Inflammatory myxohyaline tumor of distal…
No immunohistochemical stains are needed to diagnose this anal melanoma but Modern Pathology can help evaluate the anticipated outcome. Nagarajan P, Piao J, Ning J, Noordenbos LE, Curry JL, Torres-Cabala CA, Diwan AH, Ivan D, Aung PP, Ross MI, Royal RE, Wargo JA, Wang WL,…
