MODEL-AD
@Model_ad_alz
Model Organism Development and Evaluation for Late-onset AD. NIA collaborative effort between IU,JAX,UPitt,UCI&Sage Bionetworks to develop new models for LOAD
It is so important that we use the right models to understand disease. We are hoping to make those right models for #Alzheimers in the aim to #ENDALZ once and for all!
.@NatureNews makes it crystal clear why we need to keep developing #Alzheimers mouse models. Featuring @Model_ad_alz, @GHowell_Lab: nature.com/articles/d4158…
'Proteo-genomics of soluble #TREM2 in cerebrospinal fluid provides novel insights and identifies novel modulators for #AlzheimersDisease' Lihua Wang & Niko-Petteri Nykänen... @ccrugom @Neuro_Genomics @WUSTLmed #microglia #APOE #Proteogenomics bit.ly/3vsSnug
We are hiring!!! The UCI ModelAD team is seeking a highly motivated Database Research Specialist with expertise in data integration and metadata harmonization to support large scale animal model and genomics research efforts. Full position description: recruit.ap.uci.edu/JPF09537
At #AAIC24, MODEL-AD consortium showcases growing menagerie of mouse models that reflect different flavors of Alzheimer’s disease. @Model_ad_alz ow.ly/PWCT50TrewU
Check out what we’ve been doing lately… alzforum.org/news/conferenc…
Stop by to chat about data, animal models, and more! #AAIC24 @Model_ad_alz @NIH
If you’re at #AAIC24, come by poster 16 today (Sunday) to learn more about the differential effects of the Apoe Christchurch variant on amyloid and tau pathology! @Model_ad_alz
📢 register now! Only a few seats left! jax.org/education-and-…
Check out the AlzPed webinar: An Open Science Tool Raising the Standards for Preclinical Testing of Candidate Therapeutics in Alzheimer’s Disease Animal Models Date: April 30, 2024 Time: 12:00PM ET Registration link: us02web.zoom.us/webinar/regist…
And another paper alert from the UCI ModelAD center! This time is about the interesting ABCA7 variant!
Thanks Linds! Super excited about my first publication from my post doc! Take a look friends 🧠
Paper alert from the UCI ModelAD center! Go check it out if you are interested in genetic diversity!!!
Another new paper from @Model_ad_alz in @alzdemjournals: Genetic diversity promotes resilience in a mouse model of Alzheimer’s Disease: alz-journals.onlinelibrary.wiley.com/doi/10.1002/al…
A new publication as part of our 'Glial and Vascular Contributions to Neurodegenerative Diseases' review series! Check out this exciting series, written by well-known experts in the field, on our website bit.ly/3OFQ8Kg
'Neuronal and #glial vulnerability of the suprachiasmatic nucleus in #tauopathies: evidence from human studies and animal models' @gowoon_son Thomas C. Neylan @grinberg_t @GrinbergLabUCSF @UCSF @UCSFmac #AlzheimersDisease #Circadian #microglia bit.ly/4aNHT99
'Comparison of immunoassay- with #massspectrometry-derived p-tau quantification for the detection of #AlzheimersDisease pathology' @JosephTherr @woo_marcel @gesalbla... @pedrorosaneto @MCSA_Montreal @mcgillu @lunduniversity #biomarkers bit.ly/47lSbdP
Scientists found 15 risk factors for young-onset #dementia. Many also correlate with late-onset disease. Addressing the 14 that are modifiable might prevent both. @MaastrichtU ow.ly/5Mgo50QopES
Make sure to check this out! 👇 We are excited about it and hope you will be too #Alzheimers
🧠 New brain network modeling tools were developed through MODEL-AD, a consortium of experts, which includes JAX. Read @pharmabiznews to learn how they will use them in their pre-clinical investigations, including models of late-onset #Alzheimer’s disease: pharmabiz.com/NewsDetails.as…
🧠 New brain network modeling tools were developed through MODEL-AD, a consortium of experts, which includes JAX. Read @pharmabiznews to learn how they will use them in their pre-clinical investigations, including models of late-onset #Alzheimer’s disease: pharmabiz.com/NewsDetails.as…
Microglial AD risk gene INPP5D produces less functional protein in #alzheimersdisease brain, releasing the brakes on inflammation. @BrighamWomens ow.ly/S2Ji50QmjnB
The plasma Aβ42/40 ratio was three times lower in people taking the heart failure drug #Entresto than in people with brain amyloidosis. Entresto might confound #Alzheimersdisease blood test results. @goteborgsuni @UofGlasgow ow.ly/ayIw50QmjBX
The stage was set for the next steps in #Alzheimer's research in 2018. See how researchers now incorporate new technologies & genetic diversity models to characterize the molecular pathways & subtypes associated with AD jax.org/alzheimers 🧠: resources.jax.org/therapeutic-ar…
A single-cell spatial transcriptomic and proteomic study of #immune cells in the human #CNS border compartments reveals differences in CNS-associated macrophages across age, perturbation and disease. @r_sankowski #macrophages #microglia nature.com/articles/s4159…
A kicks neural circuitry into overdrive, coaxing tau entanglement from afar. @UCBerkeleyNeuro @UON_research ow.ly/AqA050QlWw7