Markus Eckstein

🌶️🌡️Summary of my uropathology for urologists and oncologists series! 👉check it out! and retweet if you like! @urotoday @OncoAlert @Uroweb @EAUYAUrology @EAU_YAUroTech @EauPatient @niklas_kluemper @onkowissen x.com/Markuseckstein…

Sequential inguinal-LN biopsies in 24 patients with SLE, SSc, RA & IIM reveal that a single infusion of CD19-CAR-T cells eradicates intranodal CD19/20⁺ B cells (0 cells mm-² in all 12 cases) and collapses germinal-centre architecture (FDC-, TFH- & Ki-67-negative). By contrast,…

5/5 🚀 Outcomes: All 12 CAR-T pts in drug-free remission at 3 mo; protein-treated pts needed retreatment despite peripheral aplasia. Lesson: depth and location of depletion matter—CAR-T sets the benchmark for future B-cell therapeutics. #Autoimmune #CARTcells

4/5 📉 Plasma cells persisted in all arms, but CAR-T cut CD19⁺CD138⁺ plasmablasts by 59 %. CD3⁺ T cells & CD68⁺ macrophages stayed stable—showing a precise B-cell hit, not wholesale tissue damage. #PrecisionImmunology

3/5 🔬 Follicular architecture: CAR-T obliterated germinal centres—FDC network gone, TFH absent, Ki-67 low (median score 0/8). Protein drugs kept residual follicles (median 4–6). Deep depletion = GC collapse. #GerminalCentre

2/5 🧮 In-node B-cell change (CD20): CAR-T 100 % clearance → OBI –92 % → RTX –86 % → BLI –69 %. Only CAR-T drove CD19/CD20 to 0 cells mm-² in every patient. Peripheral counts alone overestimate response! #BcellDepletion

1/5 📊 24 autoimmune pts (SLE, SSc, RA, IIM): OBI n=4, BLI n=4, RTX n=4, CD19-CAR-T n=12. Inguinal LN biopsies pre-tx & 30–86 d later (peripheral B=0). IHC for CD19/20, plasma cells, FDC, TFH, Ki-67, CD3, CD68. #RheumResearch

Excited to share our paper on AI-based prediction of disease progression in squamous skin cancers in @Nature_NPJ! Great collaboration w Juan Pisula & @bozeklab using federated learning & explainable AI for high accuracy while preserving patient privacy: nature.com/articles/s4169…

Prof. Constanze Schmidt ist jetzt Direktorin der Klinik für Kardiologie und Pneumologie der Universitätsmedizin Göttingen (UMG) – und derzeit die einzige Frau in Deutschland mit einem Lehrstuhl für Kardiologie. 2022 erhielt sie eine Else Kröner Clinician Scientist Professur. 🎉

Roadmap HER2 3+ PanTumor Real word data 📊 biopsy X surgery resection shows that bladder, uterine, gastric, salivary tumor are the top 🔝 winners See more ⤵️ jamanetwork.com/journals/jamao… @OncoAlert #OncoAlertAF

Fantastic new work from @SRosshart in @NatureComms „ONE MICROBIOTA TO RULE THEM ALL“ 📢 New in @NatureComms: A single oral dose of wild-mouse gut microbes transforms lab mice into “TXwildlings”. The wild microbiota dominates, builds mature immune profiles & aligns mice with…

In this special episode Joshua Meeks, MD, PhD, of Northwestern Medicine, joins the Uromigos to give a stellar overview of emerging data in the NMIBC space. There is also a discussion on the recent FDA Oncologic Drug Advisory Committee ruling for lower risk patients. 🎙️ GU…

🎉🔬 The 3d episode of my Uropathology series tailored for Urologists & Oncologists is OUT NOW! Dive into the world of genitourinary cancers and enhance your expertise 🌟🩺 Featuring insights for @AmerUrological, @Uroweb, @ASCO, @PathSoc. Don't miss out! #Uropathology…

In the first part we tried to understand the architecture of regular urothelium and key markers expressed in different layers of it. This important to understand why urothelial cancer can appear with multiple molecular and histological subtypes.