Mark A. MacLean, MD, MSc, FRCSC
@MarkMaclean10
Neurosurgeon | Spine Surgeon | Interested in Neurotrauma | Fellowship @UPMC @Pittneurosurg - AO Spine | Residency @dalhousieU | @NREFORG Research Fellow
Check out our recent review, "Fundamentals of Acute Care for Patients with Traumatic Spinal Cord Injury", in Neurosurgery Clinics of North America. sciencedirect.com/science/articl… @UPMC @PittNeurosurg @DALsurgresearch 1/2
The role of posterior column osteotomies versus lumbar decompressions in improving lower extremity motor strength in adult spinal deformity patients with preoperative motor impairment doi.org/10.3171/2025.3…
Feeling very fortunate to graduate from @PittNeurosurg with an @AOSpineNA fellowship in spine surgery. Incredible year. No shortage of learning opportunities at Presbyterian hospital. Grateful to have worked with some amazing people along the way.

Who doesn’t love a great debate?? Cervical spine debates are happening now in Room 253 at the 2025 AANS Annual Meeting! Don’t miss the action—expert insights, lively discussions, and tough questions on the biggest topics in cervical spine surgery! #AANS2025 #SpineSurgery…
Extremely proud of our team for this work! We made a predictive model for intracranial contusion/hematoma expansion. A notoriously difficult disease to manage especially in the young. Check it out! @TheJNS @UTSWNeurosurg @utswspine @UTSWMedCenter pubmed.ncbi.nlm.nih.gov/39752651/
1. What are the benefits and risks of GLP1? Our new study in @naturemedicine comprehensively maps all the benefits and risks of GLP-1 receptor agonists (GLP-1) (Ozempic, Wegovy, Mounjaro, Zepbound). By @Biostayan, Taeyoung Choi and me 🧵 nature.com/articles/s4159…
Check out our new publication: A Critical Appraisal of the Application of Frailty and Sarcopenia in the Spinal Oncology Population @simplyant_ @JohnHShinMD @DrFehlings @SahgalArjun @DanielSciubba @WendeNGibbs @DalhousieU @DALsurgresearch @DalMedSchool journals.sagepub.com/doi/10.1177/21…
Cervical deformity correction: comparison of neurological, radiographic, and patient-reported outcome measures by three-column osteotomy level doi.org/10.3171/2025.4…
Check out our new publication: "Paroxysmal Cortical Slowing Predicts Post-traumatic Epilepsy After Severe Traumatic Brain Injury" link.springer.com/article/10.100… @NeurocritCareJ @DalMedSchool @UPMC @PittTweet @PittNeurosurg
Dr. Cameron Elliott | 2024 CJNS Distinguished Reviewer of the Year The Canadian Journal of Neurological Sciences sincerely appreciates the numerous, timely & high-quality manuscript reviews completed by Dr. Elliott over the past year. Thanks @JournalCJNS cnsf.org/journal/review…
JSNTCC is excited to award Dr. Huguenard and Dr. MacLean the Natus Resident/Fellow Awards for neuro-critical care and TBI, respectively. Be sure to join us for their talks on Sunday, April 27 starting at 4:02 pm! #AANS25 #neurotrauma #TBI
In a Phase II clinical trial, we show that stereotactic inject’n of 90-Yttrium is safe/effective for use in cystic sellar lesions (eg craniopharyngioma). 32P is not available in N. America - hopefully these findings will renew interest in this approach journals.lww.com/neurosurgery/a…
There is a lot of buzz about our new paper in Nature Medicine on the effects of LLMs (GPT-4) on physician management reasoning! I had TONS of fun working on this -- but what it MEANS requires some unpacking. A 🧵⬇️ x.com/EricTopol/stat…
A randomized trial of GPT-4 vs 92 physicians with or without this #AI LLM for performance on patient care tasks. AI improved physician performance, on par with AI alone (based on 5 clinical vignettes) nature.com/articles/s4159… @NatureMedicine @AdamRodmanMD @jonc101x
Our new open access article is online: Imaging Blood-Brain Barrier Dysfunction in Drug Resistant Epilepsy. Hopefully this technique will provide an opportunity to study new directed therapies. @IlaeEs @IlaeWeb @epilepsysociety onlinelibrary.wiley.com/doi/full/10.11… #epilepsy #seizure