Kyle Cromer

The future of CRISPR therapies will be direct in vivo delivery to cells in the body! One step in that direction for hematopoietic disorders is our pre-print led by @MackenzieTippi @ateshw @intelliatx: biorxiv.org/content/10.110…

Just released our pre-print on bioRxiv for UNCOVERseq, an improved off-target discovery platform for Cas9 and base editors! Great collaboration with the awesome team at IDT @idtdna biorxiv.org/content/10.110…

I recently gave UCSF Hem/Onc Grand Rounds and wanted to share a recording of that lecture for those interested - discussing strategies in my lab to engineer erythropoiesis! youtube.com/watch?v=X9IRnE…

Glad to have played a role in this work published in @MolTherapy showing high efficiency in vivo transduction of HSCs using self-complementary AAV. Congrats to the Nakauchi Lab @StanfordMed and Wilkinson Lab @awilkinsongroup @UniofOxford: shorturl.at/vpmxK

From growing up on a cattle farm to leading a lab at @UCSF, Dr. @M_Kyle_Cromer shares his career path & his exciting work using genome editing to add new functions in cells to enhance therapies. peoplebehindthescience.com/dr-kyle-cromer/ Episode support provided by @labnerds @UCSFMedicine #CRISPR

Really proud to publish our work engineering synthetic EPO receptors in @NatureComms! This brings us one major step closer to making RBCs in bioreactors: rdcu.be/d7WhB Read the Behind the Paper blog post for a personal account of this work: shorturl.at/fIey5

My lab's work using genome editing to correct alpha-thalassemia was just published in @CellReports. Great collaborative work w/ Matt Porteus @StanfordPeds, Vivien Sheehan @EmoryMedicine, & Tippi MacKenzie @UCSFSurgery: sciencedirect.com/science/articl…

Exciting new publication in @natBME from our team @UCSFSurgery & @StanfordPeds! We used CRISPR to introduce a naturally occurring genetic variant that enhances RBC production from edited human HSCs. Full paper: rdcu.be/dK2f5 Blog post: rb.gy/zc8hzp

Really proud of this one! Used syn bio tools & genome editing to create inducible signaling receptors to remove cytokine dependence for RBC differentiation. Great collaborative work with Porteus Lab @StanfordPeds biorxiv.org/content/10.110…

Was great to have played a small role in this work just published in Developmental Cell. Congrats to Kyle Loh's group @Stanford , led by @jonas_fowler & @sherrylizheng: cell.com/developmental-…

Have been encouraged to post my lectures to Youtube, so here goes. This is a talk I gave in January on the recent CRISPR approval of Casgevy & what we can do in the future to lower cost & improve access to these therapies: tinyurl.com/5x6kvs25

Grateful for @MeganMolteni’s fantastic spotlight on our work to treat fetuses with genetic conditions using molecular therapies, including genome editing. I am privileged to lead a team working to make these therapies safe and effective. tinyurl.com/ypexs3sn

Pleased to have played a role in showing that transient delivery of a 53BP1 inhibitor peptide improves genome editing outcomes. Thanks to Porteus Lab @StanfordPeds & @ron_baik for leading this! @NatureComms nature.com/articles/s4146…

Article on curative therapies for alpha-thalassemia being developed by our lab and Don Kohn's Lab @UCLA rb.gy/o14pl

The very first paper to come out of my lab has just posted to @biorxivpreprint! Using genome editing to correct alpha-thalassemia: doi.org/10.1101/2023.0…

Our work using the genetics of an Olympic skier mutation to amplify the therapeutic potential of genome editing is now on @biorxivpreprint! biorxiv.org/content/10.110… Great collaborative work w/ Matt Porteus' group at @StanfordPeds

Pleased to have played a small role in this work that just went live at @NatureBiotech: nature.com/articles/s4158…

Interview on CRISPR safety just published today in Technology Networks! @Tech_Networks rb.gy/qea5

Just published an article in @MolTherapy to determine the tools that best capture CRISPR off-target activity, which will be essential to ensure safe delivery of next-gen therapies to patients! tinyurl.com/43pdyexp Collaboration with Matt Porteus @StanfordPeds & @idtdna!

Published a News & Views article about exciting new genome editing technology called PASTE! Allows researchers to site-specifically insert up to 35kb without a double-strand break: liebertpub.com/doi/10.1089/ge…