Miguel Ramalho-Santos Lab
@MRSantosLab
The Miguel Ramalho-Santos Lab does research on Developmental Epigenetics at the Lunenfeld-Tanenbaum Research Institute and the University of Toronto, Canada.
Learn more about the lab's research and news at: mrsantoslab.org and bsky.app/profile/mrsant…
Ending 2024 in style! We found that LINE1s are key “architects” of the nucleolar genome in human embryonic stem cells. This work brings together 2 facets of Barbara McClintock’s pioneering work: nucleolar organizer regions and transposable elements. genesdev.org/cgi/doi/10.1...
Also noted: Ribosomal DNA copy number is associated with body mass in humans and other mammals. rdcu.be/dZ3q3
Discussed in @MRSantosLab lit review: Stem cell activity-coupled suppression of endogenous retrovirus governs adult tissue regeneration: Cell cell.com/cell/fulltext/…
In a groundbreaking discovery, Sinai Health researchers have found that transposable DNA elements – long considered “junk DNA” because they had no known function – are critical for early human development. Congrats to Dr. Ramalho-Santos & team at LTRI! sinaihealth.ca/news/new-resea…
Recent review from @MRSantosLab. Everything you wanted to know about hypertranscription but were afraid to ask! This review discusses concepts of hypertranscription & technological advancements to probe global transcriptional shifts in stem cell biology. cell.com/trends/genetic…
Postdoc positions in the @MRSantosLab! Please RT. Upcoming departure of several very successful lab members + new funding = postdoc positions! Exciting new avenues in mouse development, hypertranscription, dormancy and environment-epigenome interactions. mrsantoslab.org
MRS reported latest from our lab on LINE1 in hESCs #ISSCR2024, Hamburg. Great to reconnect with many colleagues, + @bulutkarslioglu @EveCollignon. Excellent science, massive industry show. For respite: Art Museum, Caspar David Friedrich, “Wonderer above the sea of fog”, 1817.
@MRSantosLab lab getaway at the Centre Island..fun to take some time away from the lab and get some sunshine..:)
Anti-bias session, we made a “gender constellation”. We list stereotypically “female” & “male” characteristics & connect the dots between characteristics that describe each of us. In this way, we can think beyond the gender binary & celebrate things that make each of us unique!
