MANIFEST IO
@MANIFEST_CIRRP
UK-wide cancer immunotherapy response research platform | MANIFEST: Multiomic ANalysis of Immunotherapy Features Evidencing Success & Toxicity
Delighted to have been able to join @RickyFrazer1 & @AOlssonBrown for my pod debut 🎧 Opportunity to chat all things @MANIFEST_CIRRP: 📍UK wide collaborative effort 📈Large scale data/sample & assay harmonisation ➡️ Integrated predictive IO biomarkers 👨💻manifest-io.org.uk
🎙️ImmunoBuddies Podcast – Manifest - the final part! Endless Potential, The Future of Predictive Biomarkers for Treatment Response and Toxicity with Dr.@ZaydTippu from @TheCrick. Join us as Dr. Zayd Tippu explores the limitless potential of predictive biomarkers—what's next,…
🎙️ImmunoBuddies Podcast – Manifest - the final part! Endless Potential, The Future of Predictive Biomarkers for Treatment Response and Toxicity with Dr.@ZaydTippu from @TheCrick. Join us as Dr. Zayd Tippu explores the limitless potential of predictive biomarkers—what's next,…
In Focus: MANIFEST: Multiomic Platform for Cancer #Immunotherapy brnw.ch/21wSFZq By @DrJonLim, @ZaydTippu, @TurajlicLab, and colleagues on behalf of the MANIFEST consortium at @MANIFEST_CIRRP, @OfficialUoM, @TheChristieNHS, @TheCrick, @royalmarsdenNHS
Delighted to share our vision for the @MANIFEST_CIRRP consortium in a recent editorial in @CD_AACR 📝 Enquires re: collaboration opportunities pls reach out to us at: 📧 [email protected]
➡️ Following our inaugural @MANIFEST_CIRRP consortium meeting 📝We’re delighted to share our vision for the programme as an editorial in @CD_AACR: aacrjournals.org/cancerdiscover… Highlighting: 🧑💻Cross-Collaboration 📈Data, Sample & Assay Harmonisation ➡️Multi-modal Biomarkers
Fantastic inaugural @MANIFEST_CIRRP consortium meeting! 🧑🔬>100 consortium members in attendance 🧑🏾💻Critical discussions re: cross-collaboration & data harmonisation 🏥Key focus on improving patient outcomes Huge credit to @JuliaNeedham_ @TurajlicLab (& team) & @DrJonLim
A thought-provoking first @MANIFEST_CIRRP consortium meeting 🧠! 📈👩💻 Spotlighting emerging data/technologies across the consortium! 🧬🏥Highlighting the critical importance of cross-collaboration and harmonisation across consortium partners! Thank you to all in attendance!
Fantastic to see the first iteration of data from the EXACT study, characterising dynamic changes in peripheral immune subsets as predictors of ICI response and toxicity! 🩸💊🏥 Great presentation from @MaxEmmerichDerm in collaboration with the team at IMU Biosciences!
@MaxEmmerichDerm (@TheCrick) kicks off the second session presenting “Comprehensive blood profiling to derive immune signatures predictive of checkpoint inhibitor response and toxicity”. 🩸☢️
Our keynote speaker Elana (@UofMaryland) presenting some fantastic work on “Modelling the TME of clinical trials with virtual cells” 🦠🖥️
Ajitha Rajan (@EdinburghUni) joins us over the web to present on “Multimodal Data Integration” 🔬🖥️
Up next, Santiago Zelenay (@CRUK_MI) presents his work on setting up a “Patient Derived Tumour Fragment platform” 🧫
Up next Dominic Rothwell (@cruk_nbc) presents “cfDNA methylation profiling as a precision medicine biomarker in cancer” 🧬🔍
James Jones (@CRUK_CI) presents amazing work on “Cytokine profiling in kidney cancer translational studies” 🏥
🚨Opportunity to join the @MANIFEST_CIRRP team ‼️ We’re looking for: 💻 A Talented ML Engineer To: 💊Deliver on integrated immune-oncology biomarker signatures 📍@TheCrick @TurajlicLab 🧑💻manifest-io.org.uk Link 👇: crick.wd3.myworkdayjobs.com/External/job/L…
A great talk from Dr Pippa Corrie about the MANIFEST project. Thank you Dr Corrie for an insightful presentation.
🚨First output from the @MANIFEST_CIRRP platform‼️ 🩸PBMC derived immune signatures can predict ICI response & tox! 🧑💻 Hugely collaborative effort led by @MaxEmmerichDerm @TurajlicLab in conjunction with #IMUBiosciences 📍Watch this space for multimodal composite biomarkers
Delighted to present our @TurajlicLab work on utilising AI-assisted high dimensional PBMC profiling to predict IO response and toxicity as a late breaking poster and talk at #AACRIO2025 today. Great collaboration with our partners at #IMUBiosciences as part of @MANIFEST_CIRRP
Delighted to present our @TurajlicLab work on utilising AI-assisted high dimensional PBMC profiling to predict IO response and toxicity as a late breaking poster and talk at #AACRIO2025 today. Great collaboration with our partners at #IMUBiosciences as part of @MANIFEST_CIRRP
Delighted to welcome Lord Vallance & Baroness Merron @SciTechgovuk @DHSCgovuk Productive roundtable discussions, highlighting: 📍@MANIFEST_CIRRP's roadmap to IO biomarker discovery 🗺️UK-wide cross-institution collaboration 🧬Investing in emerging tech 🖥️Data & assay harmonisation
We desperately need biomarkers in RCC @TurajlicLab provides a stellar roadmap forward If you missed this talk/session, I encourage you to find it on the #GU25 app/website. An absolute must-watch for anyone in the field! @ASCO @OncoAlert
The future of biomarkers in RCC is challenging‼️#GU25 Need for: 📊 Sample & Data Harmonisation 🔴 Overcome pervasive heterogeneity 🩸Incorporation of dynamic measures 🧠 Collaborative efforts ➡️ Generation of multimodal biomarker signatures 🧑💻: manifest-io.org.uk
Fantastic to see integrated translational analyses presented on the podium at #GU25 🧬🔬 Elegantly presented by @AlbigesL 🚨 Watch this space for integrated molecular & spatial profiling in advanced ccRCC for patients undergoing ICI therapies 👇🏾 🧑💻manifest-io.org.uk
🚨🧬A translational start to D3 #GU25 🧬🚨 Final Survival Analysis: COSMIC-313 💉Continued PFS benefit for the triplet of Ipi/Nivo/Cabo ❌ Nil OS Benefit ‼️ Triplet limited by Tox: ⬇️ ICI # No & Dose 🔬⬆️ M2 macrophages identifies a subgroup benefitting from triplet!