Lobular Breast Cancer IRL #LivingWithLobular

A powerful message from @CosgroveNessa in The Seanad yesterday on behalf of Women in Ireland and our #BreastcancerScreening Women should know their Breast Density and understand the assoc risk, even as we negotiate the next best steps youtu.be/LLPyOWpBE-c?si…

Thanks so much @oncodaily for support, raising awareness of issues like the absence of #BreastDensity reporting. We're calling on the Irish Minister for Health @CarrollJennifer to make Breast Density Reporting Mandatory #WomensHealth oncodaily.com/opinion/siobha…

Thanks so much @oncodaily for continuing to share our message @ importance of Women knowing about their Breast Density. We're calling on our #Irish Minister for Health to mandate #BreastDensity Reporting for women who have Mammograms oncodaily.com/opinion/siobha…

Telling a Woman who has Dense Breasts that her Mammogram is 'Clear' is Incomplete Information - Siobhan Freeney @BreastDense oncodaily.com/opinion/siobha… #Health #Oncology #OncoDaily #Medicine #Cancer @CancerWorldmag

Invasive lobular carcinoma (ILC) the most common special histological subtype of #breastcancer accounting for 15% of cases. ILC has unique clinical and molecular characteristics. Info graphic from @LobularBCA Share with your Clinicians #NotAlwaysALump

5/5 - Preclinical work is expanding what may be targetable in ILC: • LOXL1, FOXA1, BET, Aurora-A inhibition • RAS/MAPK pathway • CDK4/6 inhibition via unique cell cycle wiring • Microenvironment and ER-modulating strategies The pipeline is growing fast

4/5 - A new wave of trials is testing therapies built for ILC: • AKT inhibitors in E-cadherin–deficient tumors • ROS1 inhibitors in early/metastatic settings • HER2-mutant ILC treated with neratinib • Immune checkpoint blockade in select patients A long-overdue shift!

3/5 - Standard imaging underperforms in ILC - Better tools are needed • FES PET tracks ER • FAPI, PSMA, and fluciclovine PET are promising • WB-DWI/MRI ⬆️ sensit. for bone/peritoneal mets • ctDNA may help—but needs validation in ILC Innovation is there, we need data in ILC

2/5 - How to improve diagnostic consistency in ILC? • Start with classic morphology • Add E-cadherin IHC if unclear • β-catenin/p120 when morphology & IHC conflict • Reserve molecular tools for edge cases This approach can ⬇️ misclassification & ⬆️ clinical trial inclusion

Last spring, the @elbcc brought together experts, researchers, and advocates to tackle the toughest clinical challenges in invasive lobular breast cancer After months of collaboration, our work is now out in @Annals_Oncology — and I’m excited to share some key takeaways 🧵

Delighted to see this. Confident that the Ireland's NSAC will action a similar process for #BreastCheck @NSShse once the current @HIQA evaluation of Submissions for Standardised Breast Density Reporting has been completed @LobularIreland @CosgroveNessa

Wonderful to see Lobular Breast Cancer Research like this filtering through. Thank you Rita Mukhtar! @LobularIreland #NotAlwaysALump

🕵️‍♂️2025 I-SPY2 Trial reveals 📊40.2% nodal pCR rate for lobular breast cancer! 📈20% vs. 7-8% margin rates#BreastCancerTreatment #ISPY2Trial 👉READ: oncologytube.com/2025-breast-ca… Dr. Rita Mukhtar, MD, shares how #MammaPrint @Agendia boosts treatment. @puneetsinghmd @RenoHemonc…

The courage of this man is something to behold and it was a privilege to meet Tristan, Susan’s brother John and campaigners to hear their compelling call to action. Susan was an amazing woman and I hope that, together, we can build the plan we need to save women’s lives.

Dr Susan Michaelis was diagnosed with lobular breast cancer in 2013 and pushed for further research into the disease. Yesterday, her husband Tristan met with the health secretary Wes Streeting - a meeting Susan had hoped to attend herself before she died.

Thank you @GuiNaderMarta for sharing this newly published study Association of HER2-low with clinicopathological features in patients with early ILC Kudos to @VanBaelenKaren @ChristineDesme2 and all contributing authors and coauthors …ast-cancer-research.biomedcentral.com/articles/10.11…

Susan's Legacy ❤ Following the very recent death of @SusanMichaelis1 founder of The Lobular Moonshot Project @lobularmoonshot continue their efforts to raise Funding for Lobular Breast Cancer Research led by @RobClarkeLab www-bbc-co-uk.cdn.ampproject.org/c/s/www.bbc.co…

Life saving information that's 'seen' on Women’s Screening Mammograms should NOT be withheld from those Women beingdense.com/2025/07/15/can… Seeking cross-party support for Mandatory Breast Density Reporting for Women who have Mammograms in Ireland @OireachtasNews

Such important information for all Women who have Mammograms. The efficacy of Mammograms to detect #ILC Invasive Lobular Breast Cancer in Dense Breasts can be as low as 11% ❗ Why is this information withheld from Women’s Breast Screening Results?

After nearly 10 yrs advocating for Breast Density Reporting, I'd like nothing more than for BreastCheck @NSShse to take responsibility and share this information with Women. Until then, I urge Women to make the Request using this Form #TellMeMyBreastDensity

Thanks so much @Lucyelkins1 @DailyMail for drawing attention to this. There's been too much obfuscation on this issue. International studies support informing Women about their #BreastDensity and educating about Supplemental Imaging #TellMeMyBreastDensity