LifeScienceAlliance

This study reveals that PTEN modulates bladder urothelial immunity by regulating Akt, NFκB, and FAK signaling, shaping susceptibility to urinary tract infection. @kidneytweets @sarah_linn16 @skyebochter life-science-alliance.org/content/8/10/e…

Have you seen this paper that was recently published in LSA? The rewiring of cAMP/cGMP and LDH signalling drives cardiac hypertrophy in Pde5a-/- mice @manuelapel97068; @CNRsocial_ hubs.la/Q03xrtHK0

Multiple protein-protein interaction domains non-redundantly contribute to the function of Tudor scaffold protein in formation of biomolecular condensates and germline development in Drosophila. @murraystateuniv @uofl @ky_inbre hubs.la/Q03xrvzW0

Check out this recently piblished paper in LSA: In vivo detection of antisense HIV-1 transcripts in untreated and ART-treated individuals hubs.la/Q03x-W-70"

HINT1's density-dependent shuttling regulates nuclear transcription at low density and cytoplasmic actin remodeling at high density. life-science-alliance.org/content/8/10/e…

Take a look at this Methods paper recently published in LSA: A lyophilized open-source RT-LAMP assay for molecular diagnostics in resource-limited settings hubs.ly/Q03xPldV0

TLR-induced STK25 activation promotes IRF5-mediated inflammation hubs.la/Q03x3bF50

This work shows that STAT1-IFITM3 regulate cell inflammatory response and parasite clearance through autophagy, which provide new insights in how autophagy contributes to cell defense to C. parvum. life-science-alliance.org/content/8/9/e2…

This study reveals that PRMT1 forms functional helical oligomers that enhance substrate binding and activity, with implications for cancer cell proliferation and RNA metabolism. life-science-alliance.org/content/8/9/e2…

"Have you seen this paper that was recently published in LSA? Loss of PLA2G4E compromises synaptic structure and cognitive outcomes in mice @Cima_unav hubs.ly/Q03wF0g40"

It has been demonstrated that antisense HIV-1 transcripts promote viral latency in vitro. Here, we used digital PCR and sequencing to show that antisense HIV-1 is expressed in people who are on or off antiretroviral therapy. life-science-alliance.org/content/8/9/e2…

Multiple protein-protein interaction domains non-redundantly contribute to the function of Tudor scaffold protein in formation of biomolecular condensates and germline development in Drosophila. @murraystateuniv @uofl @ky_inbre life-science-alliance.org/content/8/10/e…

This work illustrates the importance of accounting for EPIC version in DNA methylation-based tools, specifically in research scenarios when samples profiled across different versions are harmonized. hubs.la/Q03wqD6h0

Novel open-source diagnostic tool offers affordable, reliable pathogen detection for resource-limited settings. Read the article here life-science-alliance.org/content/8/10/e… and the press release here eurekalert.org/news-releases/…

The transcription factor IRF5 functions as a master regulator of innate and adaptive immunity and the STK25 kinase was identified as a new modulator of TLR-induced IRF5 transcriptional activity. life-science-alliance.org/content/8/9/e2…

This study reveals PLA2G4E as a critical regulator of dendritic development, synaptic function, and memory, underscoring its physiological role in the brain. @Cima_unav life-science-alliance.org/content/8/9/e2…

Check out this recently published Research Article in LSA: Sephin1 reduces TDP-43 cytoplasmic mislocalization and improves motor neuron survival in ALS models hubs.la/Q03vLNqh0

Thrilled to share this #epigenetics work comparing #Illumina #EPIC v1 and v2. Authors find significant readout differences in #EpigeneticClocks, #celltype, lifestyle #biomarkers between versions, and offer recommendations to mitigate version effects life-science-alliance.org/content/8/9/e2…

Sephin1, an UPR pathway modulator, mitigates TDP-43 cytoplasmic localization and toxicity in ALS motor neurons, improving their survival and showing potential as a therapeutic for ALS. life-science-alliance.org/content/8/9/e2…

DEK promotes mammary hyperplasia and is associated with H3K27me3 epigenetic modifications @LMPriVin_PhD @CincyResearch and @CincyChildrens @ReviewCommons hubs.la/Q03tM1G80