KinnunenLab
@KinnunenLab
Research group of Tuure Kinnunen at @UniEastFinland. All things immunology, with a particular interest in T cells and autoimmunity
T-solupopulaatioissa tapahtuu tyypin 1 diabeteksen kehittymisen eri vaiheissa muutoksia, joista voisi ehkä tulla biomarkkereita hoitoon, havaitsi FM Anna-Mari Schroderus väitöstutkimuksessaan. Väitös Kuopiossa 13.12.2024. @ClinmedUef @UEFMetabolicRC uef.fi/fi/artikkeli/f…
Verenkierron CD8-positiivisissa T-soluissa tapahtuu erityyppisiä muutoksia tyypin 1 diabeteksen kehittymisen eri vaiheissa, osoittaa Itä-Suomen yliopiston tutkimus. Tieto voi auttaa tyypin 1 diabeteksen kehittymisen ennustamisessa. @KinnunenLab @SchAnnMari uef.fi/fi/artikkeli/t…
🌍 QuantumScale training sessions happening across continents! Same commitment everywhere: Your breakthrough = our success Real support. Real results. Real partnership. hubs.la/Q03rBg7X0 #GlobalScience #SingleCellRNA #ScaleBio
Interesting observation: turns out mouse PD-1 is less inhibitory than human PD-1, so many observations in mouse cancer immunotherapy models may not hold true in humans. Another fine example why we need more human studies and/or more humanized rodent models.
Thrilled to share our @SciImmunology paper! Rodent PD-1 is weaker than human PD-1 (reduced ligand binding & signaling) & lacks a conserved vertebrate motif. Humanizing mouse PD-1 disrupts T cell anti-tumor responses, raising many questions. Kudos to @MasubuchiTakeya for leading…
An exciting advance in Type 1 diabetes First person to receive her own stem cells, reprogrammed with transcription factors, to reverse it! @CellCellPress sciencedirect.com/science/articl… @Nature nature.com/articles/d4158…
Huge congratulations @SchAnnMari for brilliantly defending your thesis today! And many thanks @lettipitko for acting as the opponent and leading the inspiring discussions.
Doctoral defence of Anna-Mari Schroderus, MSc, 13 Dec 2024: Alterations in T-cell landscape observed at different stages of type 1 diabetes progression. @ClinmedUef @UEFMetabolicRC uef.fi/en/article/doc…
Interesting early success by CAR-T therapies to treat (highly selected!) patients with severe autoimmune diseases, like lupus.
How engineered T cells are changing the face of autoimmune diseases via B cell depletion science.org/content/articl… @ScienceMagazine @NewsfromScience @jcouzin open-access
New paper out @Nature - why are males more vulnerable to severe infections (ex acute #COVID), while females suffer more from autoimmunity (SLE, MS etc and also #LongCovid)? sex chromosomes or hormones? Here we studied adaptation of human immune systems to gender-affirming…
Ok, so this is the future I guess. Someone made an AI-generated 30 sec highlight of our research paper. Looks and sounds very convincing on the surface, but on a closer look the pictures and texts in the animation are complete gibberish…
An early CMV infection can reprogram your immune system's 'software' for years, like a computer update that sticks around. @KinnunenLab @ClinmedUef @helsinkiuni @UniTurku @UniOulu sciencedirect.com/science/articl…
Two distinct signatures were detected in a subset of circulating, highly differentiated CD8-positive T cells in children at different stages of type 1 diabetes development. The study was led by prof. Tuure Kinnunen at the #UEF. @KinnunenLab @SchAnnMari uef.fi/en/article/dis…