Kiessling Group

Ever wished you could zoom in more? @W_Shiwei co-advised by @ChemicalBiology and @eboyden3 expands a hydrogel up to 20x original size with brain tissue inside. This tool will enable nanoscale-resolution imaging without laborious iterations. nature.com/articles/s4159…

Getting in the spooky spirit early 👻Our glycan-costumed virus-like particles vaccinate against melanoma. Congrats to Valerie, @AdeleGabba, and collaborators: Irvine Lab, @shaleklab, @johnsonchem, & Finn Lab 🧪 pubs.acs.org/doi/full/10.10…

She speaks 5 languages, is a talented artist, understands the power of a Kimwipe extraction, and is a synthetic powerhouse for our biosynthetic team - read this profile of @lsoyoung327! technologyreview.com/2024/08/27/109…

Introducing our newly minted PhD, Dr. Valerie Lensch!🎉 Valerie gave an awesome talk that demonstrated the wide scope of science she has been able to achieve in both our group and @johnsonchem--she engineered multivalent molecules to combat both cancer and plastic waste!

Checkout our preprint doi.org/10.26434/chemr… on the Energetic Landscape of CH–pi Interactions in Protein–Carbohydrate Binding authored by the amazing Alli Keys from our group.

CH-PI(e) ! interactions influencing glycan recognition of human galectins. Congrats Dr. Rajeev Chorgade, Dr. @RogerDiehl5, Alli and others on this awesome publication that came out a few weeks ago in @JACS_Au 🥧 pubs.acs.org/doi/full/10.10…

@mike_wuo @chaaawie @TeddyWarner4 led a team to probe the consequences of antibiotic treatment on the mycobacterial cell envelope (#TB) in real time. They found that the probe reveals phenotypic differences between #antibiotics. pubs.acs.org/doi/10.1021/ja… ( a drug cocktail below)

Did you know that different drugs can kill bacteria in such different ways? Check out how @mike_wuo's N-QTF probe allows us to see the distinct cellular phenotypes of mycobacteria upon antibiotic treatment! pubs.acs.org/doi/10.1021/ja…

Check out @amanda_peiffer and @duganam's review on how soluble human lectins maintain microbial homeostasis at the host-microbe interface! annualreviews.org/content/journa…

Effa, one of our star undergraduate researchers, presented her work today at the @urop_mit symposium in the Chemistry Department! Way to go! :)

Headed to New Orleans for #ACSSpring2024? Be sure to catch presentations from our group: Valerie will be presenting on Sunday at 3:55 PM and @vicmarando and @ChemicalBiology on Tuesday at 12:55 and 2:10 PM

Dr. Jill Alty, a postdoctoral researcher in the @KiesslingGroup has brought to life the PoWER conference (to be held July 11-12, 2024), the goal of which is to showcase polymer research conducted by women. chemistry.mit.edu/chemistry-news…

Congratulations @dsyangta Dr. Deepsing Syangtan on his big degree! His research that spanned from glycan roles in stem cell fate decisions to the gut microbiome was tied together beautifully in yesterday's defense. We will miss you greatly! #glycotime

A perfect stocking stuffer for your chemical biologist: This season, decorate your mannose with fluorophores to make them glow! Mannose-specific labeling using our biosynthetic incorporation strategy out in JACS now. Way to go, @lsoyoung327 & @vicmarando! pubs.acs.org/doi/full/10.10…

This hot-off-the-press publication is ~just right~ 🐻Check out our physical organic deep dive into the selectivity of squaric esters. Congrats to @kitaylor13 , Jordan, @HallieTrial , @AlanWyldeC, and @ChemicalBiology 🙌 pubs.acs.org/doi/full/10.10…

In this Graduate Student Spotlight, the @KiesslingGroup's Alexxandra Sosa Guir shares the thing she finds most mind-bending, the fragrance she’d choose for a never-ending scented candle, the skill she’d like to master, and more! chemistry.mit.edu/chemistry-news…

I’m so excited for this conference!! We have an amazing team of organizers and a powerhouse lineup of speakers. Mark your calendars for PoWER 2024! Feel free to reach out with any questions or interest in involvement #womeninstem

Congratulations to Dr. Katherine I. Taylor! Katherine elegantly tied together her thesis work on the chemoenzymatic synthesis of galactofuranose polymers and lysine reactive squarate probes—The group surprised her with her favorite molecules in stained glass form!

Happy birthday, @ChemicalBiology! We appreciate how curious, driven, and thoughtful you are as our group's leader🧪👩‍🔬 #DoYouRememberthe21stNightofSeptember #EarthWindFireThrowback

Congratulations to our very own, Carolina Ortiz Cordero (@carolinaortizco), for this esteemed honor! We are excited to learn what you discover about glycans in cancer and neuromuscular disorders as an HHMI #HannaGrayFellow