Kalluri Lab
@KalluriLab
Research Lab of Dr. Raghu Kalluri. Unraveling the biology of cancer and other diseases to develop novel diagnostics and therapeutics.
Big week for KL trainees! Austin took the stage at @MDAndersonNews Annual Post-Baccalaureate Symposium. Terrific talk by our aspiring physician about his work in the lab 👍
Proud to share that our Beatriz won 🎉 Best Poster - Pre-Candidacy 🎉 at last week’s @MDA_UTHGrad Graduate Student Research Day. Awesome work!
Raghu at @RTI_UMassChan for the RNA Therapeutics meeting, sharing the lab’s latest work on exosomes in cancer diagnostics and therapeutics.
📣Coming Soon: Extracellular Vesicles and Exosomes Biology Core Facility (EVcore) A first of its kind facility to support your EV research needs including isolation, characterization, imaging, engineering and more. Grateful to @CPRITTexas for supporting this resource. Stay…
Yesterday we celebrated Xin’s graduation from the Bioengineering PhD program @RiceUniversity. 🎓🦉 Congratulations Dr. Luo! 🎉🎉🎉
Congrats to KL postdoc @miguel_persilva on receiving an EDA Julia Polak Award from the European Society for Biomaterials! 🎉🎉🎉 Miguel is a talented scientist and highly deserving of this recognition. We are so proud!
📢Honored and grateful to receive the EDA Julia Polak Award 2025, @ESBiomaterials amongst such bright young researchers—an inspiring recognition that celebrates innovation, resilience, and also #pancreaticcancer therapies! 🙏 to my supervisors, friends, and family. @YSF_ESB
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Had the honor of hosting @Aiims1742 for his induction into the Association of American Physicians. A friend, colleague and collaborator extraordinaire, Anirban is The Man, and is most deserving of this recognition (I should be 👉🏽 at him). @nyulangone is getting a good one, and we…
Results from Phase I trial of iExosomes coming to you live from @AACR! 🗓️April 29 ⏰3:20 PM CT @KalluriLab discovery ➡️ patients in only 5 years. Join us in person or online!
Systemic targeting of mutant KRAS in #PancreaticCancer with inhibitory exosomes (iExosomes). Very proud of this farm-to-table study (mice to Phase 1!) from @MDAndersonNews Moonshot team & presented as a short talk by @Val_LeBleu #AACR25 abstractsonline.com/pp8/#!/20273/p…
A true “farm to table” effort at @MDAndersonNews funded by our #PancreaticCancer Moonshot. The 1st clinical trial of systemic exosomes targeting mutant KRAS in metastatic pancreatic cancer. Five years from @rkalluriMDPhD discovery to patients. No DLTs whatsoever to speak of.
ICYMI an interesting preprint from @KalluriLab @MDAndersonNews that addresses the pivotal question of targeting the correct immune checkpoint in combination with KRAS inhibition in #PancreaticCancer. Hint: it may not be aPD-1! And why blocking CTLA4 may have greater efficacy.
Raghu delivers the keynote address at #VESICON2025 and is recognized as the Guest of Honor. Great to share our latest work in EVs, and thanks to @IEVSIndia and @MahindraUni for hosting!
KRASG12D-Specific Targeting with Engineered Exosomes Reprograms the Immune Microenvironment to Enable Efficacy of Immune Checkpoint Therapy in PDAC Patients medrxiv.org/content/10.110… First in human personalized medicine with exosomes! @KalluriLab @Aiims1742
Our most recent work provides strong rationale for combination of KRAS inhibitors & anti-CTLA4 in clinical trials. biorxiv.org/content/10.110… KRASi synergize with anti-CTLA4 to prevent resistance by epigenetic reprogramming of Tregs & TLS recruitment. @Aiims1742 @KalluriLab
📣Our latest study is out this week in @ajogmfm. Amniotic fluid evRNA and cfRNA reveal fetal adaptations in twin-twin transfusion syndrome. Great to work with the awesome @jackie_parchem and colleagues at @UTHealthHouston OBGYN on this project. 🔗ajogmfm.org/article/S2589-…
New preprint by @mcandrews_kate (previously @KalluriLab, now PI at @MDAndersonNews): CDK8 remodels the tumor microenvironment to resist the therapeutic efficacy of targeted KRASG12D inhibition in #PancreaticCancer In this preclinical study, Kate demonstrates that while acute…
Pleased to share article ✌️this week! We show that allogenic and non-immunogenic exosomes can be engineered to induce specific immune responses, with therapeutic potential. Full article is online @acsnano now! ⬇️ pubs.acs.org/doi/10.1021/ac…
📣Our latest review article is now online at @acsnano ! “Natural and Bioengineered Extracellular Vesicles in Diagnosis, Monitoring and Treatment of Cancer” Read the full article here: pubs.acs.org/doi/10.1021/ac…
It was our privilege to host Hidde Pleogh for his 1️⃣st visit to @MDAndersonNews, and most importantly, his final stop before retirement‼️ This Smith Family Distinguished Lecture was one for the books!
