Jinming Gao Lab

New hitchhiking STING agonist by the @WilsonLabVU using albumin as a carrier target: nature.com/articles/s4155…. Shuyue and I wrote an opinion piece: nature.com/articles/s4155…. Hope to see it in the clinic soon!

Excited to share our latest publication in @natBME! Big congrats to all co-authors on this highly collaborative effort – especially to first author @BlaiseKimmel for his dedication to this project! Check out the paper (open access) here: nature.com/articles/s4155…

Honored to be part of interdisciplinary team to promote @UTSWMedCenter. Magic place to ignite collaboration with Dr. Baran Sumer @HeadNeckSurgeon to advance cancer surgery and immunotherapy!

Lab holiday lunch @Gradi downtown Dallas - thankful for everyone’s pursuits and teamwork!!

Inspiring personal journey of Maggie who transitions from material science training to tackle a complex tumor immunology challenge! And her service to the @utswbme community. Well deserved Ida M. Green Award! utsouthwestern.edu/ctplus/stories… via @@utswnews

Interesting chemical probes for lysosome biology conference by the @royalsociety if you are interested. Event is free although it will require travel to the UK. royalsociety.org/science-events…

Dallas Morning News highlights UT innovation - DFW Metro is becoming the next hotbed of biotech innovation! UT schools ranked among most innovative universities in the country dallasnews.com/news/2024/06/1…

Great thanks for @IOTNmoonshot support in the past 5 years. Ray and Gang are presenting U54 progress in the #iotncapstonemeeting with STING nanodrug (NCT06022029) under clinical evaluation.

Phase 2 clinical result from 40 cancer patients is published by Dr. David Bartlett and team in cytoreductive surgery - a milestone for the pH-activatable nanosensor (Pegsitacianine) in image-guided surgery! link.springer.com/article/10.124…

Path of totality crossed Dallas at 1:40-1:45 pm on April 8, 2024! Amazing experience for the lab and university to witness and celebrate!

Please join us for the @IOTNmoonshot @utswcancer U54 seminar by Dr. Ben Stanger, Hanna Wise Professor of Cancer Research at UPenn for a seminar "Shifting Paradigms in a Harsh, Cold, and 'Undruggable' Tumor". Anticipate light-out talk after day of total solar eclipse!

A study lead by @JinmingGaoLab discovers protective ‘acid wall’ formed by cancer cells. These higher acidity levels on the outer edges of tumors could rebuff immune cells. Learn more: bit.ly/4ahPXyl

Honored to be inducted into @aimbe college of fellows and celebrate with our BME chair @SamuelAchilefu, Lily, Lan and AIMBE President @profjoycewong!

Nanoparticles developed at UTSW effectively fight tumors: Newsroom - UT Southwestern, Dallas, Texas utsouthwestern.edu/newsroom/artic…

Many of us know that tumors have an acidic microenvironment. But how acidic is cancer actually? 🤔 Led by Qiang in @JinmingGaoLab, we quantified cancer acidosis using our robust ultra-pH-sensitive nanoprobes. We found acidic thresholds reach below pH 5.3! rdcu.be/dAjQ5

Qiang et al revealed cancer cells excrete protons into a polarized extracellular region, driving the pH below 5.3 @natBME. The severe acidity is toxic to T cells but not cancer cells, highlighting a tumor survival strategy against immune surveillance. rdcu.be/dAgFR

Heart felt thanks to Jian, Suxin, Maggie and all the coauthors for persevering through a comprehensive study elucidating the importance of STING-cDC1 in antitumor immunity. Grateful to support from @IOTNmoonshot and @CPRITTexas scim.ag/5TL

A new #nanoparticle design selectively activates the innate #DNA-sensing #cGAS-#STING pathway in conventional type I #DendriticCells to boost anti-#tumor activity. @JinmingGaoLab Learn more: scim.ag/5TL

Stimulating two-day discussions @ForbeckForums with thought leaders in cancer nanotechnology. Grateful to co-chair @NatalieArtzi and all attendees for an invigorating forum at beautiful Pacific Grove!

Excited to host Dr. Warren Chan @TheChanLab, a pioneer in cancer nanotechnology and Professor of Biomedical Engineering from UToronto for the @IOTNmoonshot @utswcancer U54 seminar. His lecture title is "Nanoparticle delivery to solid tumors". Don't miss it!