JTH

@JTHjournal

JTH will no longer have an active presence on X. While this account will remain available as an archive, we will no longer monitor comments or post new content.

Joined November 2016

7KFollowing

10KFollowers

JTH@JTHjournal · May 13

JTH will no longer have an active presence on X. While this account will remain available as an archive, we will no longer post new content or monitor engagement. To continue receiving updates, follow us on: LinkedIn: bit.ly/3GMe8Lw BlueSky: bit.ly/4dizFHF

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JTH Retweeted

Marc Carrier@MarcCarrier1 · Mar 7

The Repeat Study addressed a really important knowledge gap! The incidence of recurrent events following an ante- or postpartum VTE is 2.4% person-years. The cumulative risks are 6%, 13%, 17%, and 30% at 2, 5, 10, and 30 years respectively. jthjournal.org/article/S1538-…

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Nicolas Gendron@GendronNico · Mar 9

🚨How to deal with interference on heparin anti-Xa activity caused by oral factor FXa inhibitors: Communication from the @isth SSC Subcommittee on Control of Anticoagulation @JTHjournal 🙏 Great team work with @CukerMd @LanaCastellucci @thachil jthjournal.org/article/S1538-…

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JTH@JTHjournal · Mar 12

📰How we treat severe inherited antithrombin deficiency: lessons from cases homozygous for the Budapest 3 variant👉 pubmed.ncbi.nlm.nih.gov/39933654, publicado en @JTHjournal

SServicio de Hematología. Hosp. U. Morales Meseguer@crh_MoralesIMIB · Mar 12

Nuestros compañeros C. Bravo y J. Corral @IMIB_RMurcia @CIBERER y @Catedra_Hemato junto a colegas de universidades de Bruselas🇧🇪Johns Hopkins🇺🇸y Debrecen🇭🇺aportan experiencia personal en el tratamiento de deficiencia en homocigosis de antitrombina pubmed.ncbi.nlm.nih.gov/39933654/

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JTH@JTHjournal · Mar 7

This study provides new insights into VWF regulation in complement-mediated diseases, opening avenues for targeted therapies in TMA and atypical HUS! ✅ W1183R-CFH enhances VWF cleavage by ADAMTS-13, potentially reducing large prothrombotic multimers ✅ Identifies strong binding…

JTHjournal's tweet image. This study provides new insights into VWF regulation in complement-mediated diseases, opening avenues for targeted therapies in TMA and atypical HUS!

✅ W1183R-CFH enhances VWF cleavage by ADAMTS-13, potentially reducing large prothrombotic multimers
✅ Identifies strong binding…

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JTH Retweeted

Ang Li, MD, MS@AngLi_MD · Mar 3

Preventing arterial #thromboembolism (ATE) in high-risk cancer patients should focus on modifiable CV risk factors. Kim et al.'s study explores the link between cancer, CV risk factors, and ATE. @JTHjournal. authors.elsevier.com/a/1kh7B5TuFxMh…

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JTH@JTHjournal · Mar 4

🔍 What are the key design and feasibility challenges in pediatric DOAC trials, and how can future antithrombotic studies be improved to ensure robust and clinically meaningful results? This Study ✅ Identifies common feasibility barriers, such as sample size adjustments and…

JTHjournal's tweet image. 🔍 What are the key design and feasibility challenges in pediatric DOAC trials, and how can future antithrombotic studies be improved to ensure robust and clinically meaningful results?

This Study
✅ Identifies common feasibility barriers, such as sample size adjustments and…

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JTH@JTHjournal · Mar 2

🔍 How can we accurately measure FVIII activity in hemophilia A patients receiving efanesoctocog, particularly in those also on long-term emicizumab therapy? ✅ Efanesoctocog, an ultra-extended half-life FVIII, can now be accurately measured even with emicizumab present ✅…

JTHjournal's tweet image. 🔍 How can we accurately measure FVIII activity in hemophilia A patients receiving efanesoctocog, particularly in those also on long-term emicizumab therapy?

✅ Efanesoctocog, an ultra-extended half-life FVIII, can now be accurately measured even with emicizumab present
✅…

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JTH@JTHjournal · Mar 1

In this meta-Analysis of 16 studies (2300+ patients), ✅ Peak & trough concentrations of apixaban and rivaroxaban established 📉 ✅ Age & kidney function impact drug levels—highlighting the need for personalized dosing ✅ Findings align with known pharmacokinetic studies…

JTHjournal's tweet image. In this meta-Analysis of 16 studies (2300+ patients),
✅ Peak &amp; trough concentrations of apixaban and rivaroxaban established 📉
✅ Age &amp; kidney function impact drug levels—highlighting the need for personalized dosing
✅ Findings align with known pharmacokinetic studies…

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JTH@JTHjournal · Feb 28

A PAR4 genetic variant (rs2227376) reduces venous thromboembolism (VTE) risk by decreasing platelet activation & thrombin generation 🐁 Mice with the PAR4-P322L mutation had smaller venous clots & fewer procoagulant platelets 💡 Could targeting PAR4 signaling be a future…

JTHjournal's tweet image. A PAR4 genetic variant (rs2227376) reduces venous thromboembolism (VTE) risk by decreasing platelet activation &amp; thrombin generation
🐁 Mice with the PAR4-P322L mutation had smaller venous clots &amp; fewer procoagulant platelets

💡 Could targeting PAR4 signaling be a future…

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JTH@JTHjournal · Feb 26

🤖 AI Meets Coagulation Genetics! 🧬 Machine learning (ML) is revolutionizing genetic variant interpretation for coagulation factor deficiencies, with increasing focus on hemophilia A & B. 🔍 Key Insights: ✅ AI tools like Hema-Class improve variant classification &…

JTHjournal's tweet image. 🤖 AI Meets Coagulation Genetics! 🧬

Machine learning (ML) is revolutionizing genetic variant interpretation for coagulation factor deficiencies, with increasing focus on hemophilia A &amp; B.
🔍 Key Insights:
✅ AI tools like Hema-Class improve variant classification &amp;…

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JTH@JTHjournal · Feb 25

Interested in the fundamentals of key topics in #thrombosis and #hemoastasis? Don't miss the BRAND NEW Educational Review Series in @isth @JTHjournal Check it out 👇

IISTH@isth · Feb 11

Big news from @JTHjournal: a NEW Educational Review Series designed to break down the fundamentals of key topics in thrombosis & hemostasis!🔬 These reviews are must-read resources for clinicians, researchers & healthcare professionals. Learn more here: bit.ly/3EAaVNZ

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JTH@JTHjournal · Feb 25

Individuals with a new cancer diagnosis and no stroke history have an increased risk of ischemic stroke which varies according to site and stage. Future research is needed to identify individuals at highest risk who may benefit from preventative treatment @DebSiegal…

JTHjournal's tweet image. Individuals with a new cancer diagnosis and no stroke history have an increased risk of ischemic stroke which varies according to site and stage. Future research is needed to identify individuals at highest risk who may benefit from preventative treatment
@DebSiegal…

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JTH Retweeted

The Heart@ZHeart11768530 · Feb 18

🔴Venous thromboembolism and Duration of Anticoagulation ⤵️ #2025Review @JTHjournal 🔹Basics of diagnosis and treatment of venous thromboembolism 🔹Category of Major persistent risk factor, requiring long term anticoagulation. 🔹Learn more here: bit.ly/3EAaVNZ

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Nikola Pantic@kolja_pantic · Feb 18

Something we really needed! Comprehensive and understandable review which can be useful to all early career professionals. Thanks to @JTHjournal for this educational review series. Looking forward to the next one jthjournal.org/article/S1538-…

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JTH@JTHjournal · Feb 23

💡 Could Roxadustat be the next big thing in ITP treatment? 🔬 Roxadustat, a HIF-1α stabilizer, shows promising therapeutic potential for ITP by enhancing megakaryocyte development & immune modulation! 📊 Key Findings: ✅ Reduced ITP risk (OR 0.79, P=0.01) ✅ No significant…

JTHjournal's tweet image. 💡 Could Roxadustat be the next big thing in ITP treatment?

🔬 Roxadustat, a HIF-1α stabilizer, shows promising therapeutic potential for ITP by enhancing megakaryocyte development &amp; immune modulation!
📊 Key Findings:
✅ Reduced ITP risk (OR 0.79, P=0.01)
✅ No significant…

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JTH@JTHjournal · Feb 22

🦠 Gut microbiota & progesterone play a crucial role in bone marrow mesenchymal stem cell (BM-MSC) dysfunction in PITP. 🧬 Increased progesterone leads to BM-MSC senescence & apoptosis, impairing immune regulation. 🔗jthjournal.org/article/S1538-…

JTHjournal's tweet image. 🦠 Gut microbiota &amp; progesterone play a crucial role in bone marrow mesenchymal stem cell (BM-MSC) dysfunction in PITP.
🧬 Increased progesterone leads to BM-MSC senescence &amp; apoptosis, impairing immune regulation.

🔗jthjournal.org/article/S1538-…

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JTH@JTHjournal · Feb 21

How do structural changes in the A1 domain of von Willebrand factor (VWF) lead to type 2M von Willebrand disease? 🧬🔬 This study reveals that both misfolding and hyperstabilization of A1 disrupt platelet adhesion—offering new insights into VWF function!…

JTHjournal's tweet image. How do structural changes in the A1 domain of von Willebrand factor (VWF) lead to type 2M von Willebrand disease? 🧬🔬
This study reveals that both misfolding and hyperstabilization of A1 disrupt platelet adhesion—offering new insights into VWF function!…

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JTH@JTHjournal · Feb 19

A single amino acid replacement (D189A) switches thrombin specificity from trypsin-like to chymotrypsin-like. The observation establishes a new paradigm in the field of trypsin-like proteases. 🔗jthjournal.org/article/S1538-…

JTHjournal's tweet image. A single amino acid replacement (D189A) switches thrombin specificity from trypsin-like to chymotrypsin-like. The observation establishes a new paradigm in the field of trypsin-like proteases.

🔗jthjournal.org/article/S1538-…

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