Shinji Izuka

Take the #EXPLOREPsA survey 🧭 — led by #YoungGRAPPA to learn how PsA disease activity is assessed globally. 🕐 5–10 min 🌍 Worldwide participation welcome 🔗app.onlinesurveys.jisc.ac.uk/s/oxford/explo… @GrappaO @reumacia @rheum_cat @Lupusreference

thrilled to share our latest work from @NMSrheumatology🇯🇵, highlighting a distinct cytokine profile of anti-MDA5-positive DM, with elevations of IFN-β and λ3. The combination of serum IFN-α, β, and λ3 levels could serve as a prognostic biomarker. #MDA5 doi.org/10.1038/s41598…

Our paper is out! We show that GM-CSF drives early bone damage in RA—even before arthritis begins—and that JAK inhibitors can suppress this progression. A long journey, but worth it! doi.org/10.1186/s13075…

🧬 Can we prevent rheumatoid arthritis before it starts? 🔍 New review explores: 🪟 Windows of opportunity in the pre-arthritis phase ⚙️ Key immune & mucosal triggers 🛑 Strategies to delay or prevent RA onset 📖rmdopen.bmj.com/content/11/3/e…

Happy (or more like relieved 🫠❣️) to finally share that my work is out! It definitely took a while, but I’ve learned so much along the way. Even more grateful that I get to keep going on this research journey for a few more years🙏!! #Sjogren #Tfh 🔗nature.com/articles/s4159…

📢 New article in @RheumJnl 🔬 Baseline NFC abnormalities predict ILD progression and lung function decline in SSc over 2 years follow-up 📉 Late NVC patterns at baseline linked to worsening KL-6, mRSS, and %DLCO during follow-up 👉 doi.org/10.1093/rheuma…

💻 Integrative genomic modelling of #JIA ✅ Lasso-regularised logistic regression integrating 73 GWAS sentinel SNPs with 247 two-sample MR spatial-eQTL instruments (total = 312 variants) achieved a mean AUROC 0.695 across 50 cross-validation iterations. 🏅 Highest-weighted…

📈 Epidemiology of ANCA-associated vasculitis (AAV) in Oslo, 2000–2016 ✅ Population-based cohort (n = 528 k adults) • 97 incident cases → mean annual incidence 12.2 /10⁶ – GPA 7.3 /10⁶ – MPA 3.7 /10⁶ – EGPA 1.2 /10⁶ 📊 Incidence rose from 10.2 → 16.0 /10⁶ across the…

🔬 Nailfold videocapillaroscopy (#NVC) in #SSc and primary Raynaud phenomenon ✅ 157 pts (100 lcSSc, 27 dcSSc, 30 pRP) ✅ Capillary density already ↓ at baseline—worse in dcSSc (4.9 vs 6.2 /mm) ✅ Late NVC pattern + angiogenesis ↑ in dcSSc ✅ Early pattern ↑ in lcSSc 📉…

🔥 Chronic inflammation increases CV risk in #axSpA ✅ 245 pts — “High-CRP” = >5 mg/L in >50 % of tests (40%) ➡️ ↑ Plaques, IR & dyslipidaemia; microvascular flow ↓ ⚠️ IL-6 & CDCP-1 → CIMT ↑ & endothelial dysfunction 🛡️ PON-3 ↓ restoring endothelial health in vitro 💉…

📊 Clustering Paediatric #Behçet’s disease ✅ 600 pts → 7 phenotypes • C1 Vascular • C2 Mucocutaneous • C3 Ocular • C4 Gastrointestinal • C5 Ocular + MSK • C6 Neuro + ocular • C7 Mucocutaneous + MSK 🌍 Regional variations • Ocular ↑ in Iran • GI ↑ in…

🦠 Adaptive immunity to #SARSCoV2 in DMARD-treated #RA & #SpA ✅ 94 pts on MTX, anti-TNF, anti-IL17, etc. ✅ No viral persistence in blood/nasal/stool ✅ Humoral & CD4⁺ T-cell responses preserved ⚠️ Rituximab ↓ IgG/IgA & CD8⁺ activation 💡 CD8-focused vaccines could…

🩸⏱️ Thrombin-generation test sharpens #APS risk stratification ✅ Under vitamin K antagonists, thrombotic APS patients showed longer lag time (LT) & time-to-peak (TTP) than other anticoagulated controls ⚠️ Biggest prolongations in catastrophic APS or relapse history 🔗…

🧬🦴 WNK2 variants couple hyperosmotic stress to familial #osteoarthritis ✅ 3 rare missense alleles co-segregated with erosive hand / 1st-MTP #OA in 4 families ⚡ WNK2 expression surges in hypertrophic chondrocytes of human & mouse OA tissue 💧 Hyperosmotic stress + high…

📚 AI-driven body-composition biomarkers on routine chest CT redefine risk in #SystemicSclerosis 🖥️ 3D body composition analysis (BCA) ➡️ muscle, fat depots, bone density ✅ BCA model predicted 5-yr survival better than BMI & clinical data (AUC 0.75) ✅ Increasing…

👁️🦷 High-frequency lacrimal-gland ultrasound sharpens #Sjögren diagnostics. 📝 OMERACT grade ≥2 on 6–24 MHz lacrimal gland ultrasound ✅ Specificity 87.5%, PPV 80%—better than salivary-gland US in this cohort ✅ Sensitivity 61.5%, NPV 73.3% 🔗 Strong association with…

📱 Reliable daily ePROMs via COTIDIANA app 📝 48 pts (PsA, SjD, OA) logged VAS for pain, fatigue, sleep, mood, PGA ✅ 1–3-day test-retest ➡️ intraclass correlation coefficients ≥ 0.83 ✅ ≥4-day intervals → reliability drops (ICC 0.23–0.73) 💡 Supports personalised,…

🔄 Cycle vs Swap after first TNF-i failure in #SpA 📚 Quasi-experimental cohort: 3-yr drug-retention (2nd bDMARD) ✅ PsA: no significant difference (TNF-i→TNF-i ≈ TNF-i→IL-17i) ✅ axSpA: cycle superior (HR 1.46 for discontinuation with swap; p = 0.04)    ⤷ Effect…

📉 Sexual functioning in male radiographic axial spondyloarthritis (r-axSpA) 📊 Cohort: 113 r-axSpA vs 73 controls 📍 Composite Sexual-Experience Index: 41.8 ± 8.7 vs 50.2 ± 8.8 📍 All subdomains impaired—erectile performance, individual satisfaction, dyadic satisfaction ⚠️…

🔎 High-frequency ultrasound detects finger-pulley enthesitis—an early sign of PsA 🖐️ Digital annular pulleys (A1/A2/A4) are anatomical entheses. ✅ Case: young PsO patient, 3-month finger pain. ✅ Doppler-positive signal at A2-pulley enthesis (2nd finger) before any…