Isaiah Kletenik
@IsaiahNeurology
Cognitive Neurologist and Neuroimaging Researcher @HarvardMed @BrighamWomens @Brain_Circuits
Can a brain injury lead someone to commit a #crime? Brain imaging is increasingly introduced as evidence in criminal trials but it remains unclear which structural injuries play a causal role in criminal behavior. @foxmdphd @Brain_Circuits @BWHNeurology nature.com/articles/s4138…
Damage to the right uncinate fasciculus is strongly linked to criminal behavior—especially violent crime—more than any other brain tract. Lesion mapping confirms its key role. #Neuroscience #Brain #CriminalBehavior nature.com/articles/s4138…
New paper: Mapping Neuroimaging Findings of Creativity and Brain Disease Onto a Common Brain Circuit Published in ‘JAMA Network Open’: jamanetwork.com/journals/jaman…
Does human creativity map to a specific brain circuit? Can damage to this brain circuit increase creativity? New paper by @IsaiahNeurology @Brain_Circuits out today in @JAMANetworkOpen says answer to both is YES. Paper is open access and great thread below:
How can a brain disease increase creativity? First, we derive a brain circuit for creativity from studies of creative tasks demonstrating that they share reduced activity in the right frontal pole. @foxmdphd @Brain_Circuits jamanetwork.com/journals/jaman…
“Should brain injury factor into how we judge criminal behavior? Causality in science is not defined in the same way as culpability in the eyes of the law,” Kletenik mused. @Brain_Circuits nypost.com/2025/06/27/hea…
Nice coverage of our recent paper: “White matter disconnection in acquired criminality” in @molpsychiatry by @CUAnschutz @Brain_Circuits news.cuanschutz.edu/news-stories/s…
“The sense of the sacred is something that has really strong grounding in the human brain,” says Michael Ferguson, Ph.D: archive.ph/TpZNY Great reporting on neurospirituality in Popular Mechanics! I stand by this parting shot: “I really think that we’re just barely…
MRI scans are becoming common in the courtroom and show abnormalities in defendants brains. But can any of these abnormalities actually cause #criminal behavior. New paper from @IsaiahNeurology @Brain_Circuits @MGBResearchNews in says YES. Thread below:
Can a brain injury lead someone to commit a #crime? Brain imaging is increasingly introduced as evidence in criminal trials but it remains unclear which structural injuries play a causal role in criminal behavior. @foxmdphd @Brain_Circuits @BWHNeurology nature.com/articles/s4138…
Real and imagined images are processed using the same systems in the brain, yet most people can distinguish between the two. Now neuroscientists have identified two brain regions that keep imagined images separate from reality. go.nature.com/45kzPwj
Can brain injury cause the loss of visual imagination? We studied #aphantasia due to brain injury. Lesions were in many different regions but 100% were connected to fusiform imagery node - a region active during visual mental imagery @Brain_Circuits medrxiv.org/content/10.110…

Thank you @ScienceMagazine for covering our work of childhood environment and brain-wide white matter signatures. science.org/content/articl…
In a new study, researchers from @BrighamWomens and colleagues discovered a brain circuit for creativity. The study is published in @JAMANetworkOpen. Read more: massgeneralbrigham.org/en/about/newsr… @foxmdphd @IsaiahNeurology
Excited to present my poster at ACTRIMS: “Network Localization of Multiple Sclerosis Gait Speed Compared to Stroke” 🧠☺️ ➡️ Thanks to @IsaiahNeurology and @foxmdphd for the amazing mentorship! 🎉
A new study led by researchers at Mass General Brigham suggests that different brain regions activated by creative tasks are part of one common brain circuit. @Brain_Circuits massgeneralbrigham.org/en/about/newsr…
This fMRI study found that brain regions activated by creativity tasks mapped to a circuit centered on the right frontal pole; damage to this circuit was linked to both decreases and paradoxical increases in creativity in multiple different brain diseases. ja.ma/40WYmDZ