Isabel Wassing
@IsabelWassing
DPhil in Molecular Cell Biology in Health and Disease (University of Oxford), Postdoc at the Rockefeller University
Here is the link to a news letter article covering our finding. x.com/RockefellerUni…
New from @HironoriFunabi1's lab: CDCA7, whose mutations alter DNA methylation pattern and cause immunodeficiency, is a novel sensor for a special class of methylated DNA. #RockefellerScience rockefeller.edu/news/36393-new…
Excited to share the revised version with a new title "CDCA7 is an evolutionarily conserved hemimethylated DNA sensor in eukaryotes" now published @ScienceAdvances! Congrats @IsabelWassing, @QingyuanJia, @NishiyamaAtsuya, @KyoheiArita! science.org/doi/10.1126/sc…
New preprint from the lab led my talented postdoc @IsabelWassing! She discovered that CDCA7's unique zf-4CXXC_R1 domain acts as a novel hemi-methylated DNA binding module to recruit the nucleosome remodeler HELLS and help DNA methylation! Check out her tutorial!
Please repost! Arimura Lab is hiring! We are seeking the next generation of MagICians (technicians and a postdoc) to elucidate the structural basis of events on chromosomes🧙♀️ No prior structural biology experience is required!! Link research.fredhutch.org/arimura/en/joi…
Magnetic Isolation and Concentration (MagIC)-cryo-EM is a new method to enable direct structural analysis of targets captured on nanomagnetic beads, which requires only 0.0005 mg/mL of targets in 100 µL crude solution to make 10 cryo-EM grids. I will explain the magic behind it!
Excited to share my final PostDoc work! Introducing MagIC-cryo-EM🪄 & DuSTER🧹, these methods reduce cryo-EM sample requirements (0.0005 mg/mL), enabling ALL biologists to explore the structural basis of diverse biological events! BioRxiv: biorxiv.org/content/10.110…